Delayed uterine fluid clearance and reduced uterine perfusion in bitches with endometrial hyperplasia and clinical management with postmating antibiotic

England, G. C. W.; Moxon, Rachel; Freeman, Sarah

doi:10.1016/j.theriogenology.2012.07.009

Cited by 30 publications

(34 citation statements)

References 19 publications

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“…The exact aetiology of mating-induced endometritis is uncertain, but delayed clearance of fluid after mating or insemination appears to be an important component (England et al, 2012b). In addition, these bitches have a reduced vasodilatory response to mating (England et al, 2012b).…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence that endometritis, and particularly mating-induced endometritis, is an important clinical condition of bitches (Watts and Wright, 1995;Fontaine et al, 2009;Groppetti et al, 2010;England et al, 2012a), which results in persistence of uterine luminal fluid (England et al, 2012b); is associated with influx of increased numbers of polymorphonuclear neutrophils (PMNs) after mating or insemination (England et al, 2012a), and results in reduced pregnancy rate and litter size (England et al, 2012a,b). Interestingly, recent work has also hinted that the aetiology of the reduced fertility might be associated with bacterial contamination of the uterus, since pregnancy rates can be increased by the oral administration of antibiotics post-mating (England et al, 2012a,b).…”

Section: Introductionmentioning

confidence: 99%

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Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Freeman

Green

2013

The Veterinary Journal

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Freeman

Green

2013

The Veterinary Journal

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“…In bitches, Alvarez-Clau and Liste (2005) describe the uterine arteries only on metestrous and anoestrus, and England et al (2012) compared uterine perfusion among bitches with endometrial hyperplasia and normal uterus, before and after mating. There have also been two studies evaluating the intraovarian vessels during the follicular and luteal phases in nonpregnant bitches (Köster et al 2001, Bicudo et al 2010, one comparing intraovarian vessels during diestrus in pregnant and nonpregnant bitches (Polisca et al 2013) and one report using color Doppler ultrasonography for detecting periovulatory events in ovarian artery (Bergeron 2013).…”

Section: Introductionmentioning

confidence: 99%

Ovarian and uterine periovulatory Doppler ultrasonography in bitches

et al. 2013

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Pesq. Vet. Bras. 33(9):1144-1150, setembro 2013 1144 RESUMO.-[Ultrassonografia Doppler ovariana e ute-rina em cadelas.] Este trabalho teve como objetivo des-crever as características ultrassonográficas uterinas e ova-rianas, e dopplervelocimétricas das suas artérias nos dias periovulatórios em cadelas. Quinze ciclos estrais em 10 ani-mais foram avaliados. As características ultrassonográficas, índices de resistência (IR) e índices de pulsatilidade (IP) do útero e dos ovários em cada animal foram registrados 5 dias antes e depois da ovulação (D0). Os dados foram anali-sados estatisticamente e os resultados foram expressos em média ± erro padrão da média (P<0,05). Como resultados as características ultrassonográficas uterinas foram seme-lhantes em todos os ciclos e dias avaliados, tendo o corpo uterino um diâmetro médio de 0,85±0,02cm. Foi observado um aumento no volume dos ovários e nos diâmetros dos folículos, tendo os ovários um volume de 0,64±0,06cm 3 , e a cavidade dos folículos um diâmetro de 0,46±0,01cm no dia da ovulação. Após a ovulação, foi observado colapso dos folículos somente em alguns ciclos. A perfusão sanguínea uterina diminuiu dois dias antes da ovulação e permane-ceu inalterada até a ovulação. Após a ovulação, houve um aumento gradual na perfusão das artérias uterinas e ova-rianas, direcionando o fluxo de sangue para os ovários e This paper aims to describe the uterine and ovarian ultrasonographic characteristics and Doppler velocimetric features of their arteries in bitches during the periovulatory period. Fifteen estrous cycles in 10 animals were evaluated. The ultrasonographic characteristics , resistance indices (RI) and pulsatility indices (PI) of the uterus and ovaries in each animal were recorded 5 days before and after ovulation (D0). The data were statistically analyzed, and the results were expressed as the mean ± standard error of mean (P<0.05). In results the ultrasonographic features of the uterus were the same on all of the cycles and evaluated days. The uterus had an average diameter of 0.85±0.02cm. An increase in the volume of the ovaries and the diameter of the ovarian follicles were measured. Ovaries had a volume of 0.64±0.06cm 3 , and the follicles cavities had a diameter of 0.46 ± 0.01 cm on the day of ovulation. After ovulation, it was observed that some follicles not collapse in some cycles. Two days prior to ovulation, the uterine blood perfusion decreased. This decrease remained unchanged until ovulation. Following ovulation, we measured a gradual increase in the uterine perfusion and in the ovarian artery. This artery directed blood flow to the ovaries and increased the intra-ovarian perfusion on the day after ovulation. In conclusion, specific features are observed in the uterus and ovarian ultrasound image and Doppler values of their arteries presented on the periovulatory days and when associated allow to estimate more accurately the date of ovulation. Pesq. Vet. Bras. 33(9):1144-1150, setembro 2013 1145 Ovarian and uterine periovulatory Doppler ultrasonography in bit...

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“…In the bitch, uterine contractions occur during oestrus and are specifically increased during mating, although the initiating factors are unknown (England et al. , ). Uterine contractions presumably aid in sperm transport and are part of the mechanism by which sperm are rapidly propelled to the tips of the uterine horns (Evans ) where they establish an intimate attachment with uterine epithelium to form a sperm reservoir (Burgess ).…”

Section: Introductionmentioning

confidence: 99%

“…Uterine contractions in the bitch are also important for elimination of excess and dead spermatozoa, seminal fluid, bacteria and other contaminants that enter the uterus at mating; the frequency of uterine contractions has been related to the rate of fluid clearance from the uterus (England et al. ).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Mating‐Induced Uterine Contractions in the Bitch and Their Modification and Enhancement of Fertility by Prostatic Fluid

Moxon

Freeman

2012

Reprod Domestic Animals

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Little is known about the response of the bitch's reproductive tract to mating or of the role of male accessory gland secretions in the female. In this clinical study, the component stimuli causing mating-induced uterine contractions were investigated in 64 bitches. Basal uterine contractions were present during oestrus and a significant increase in the frequency of contractions was observed during natural mating. Neither teasing with a male nor stimulation of the vagina or cervix by vaginal or transcervical insemination (TCI) caused an increase in the frequency of uterine contractions. Increased contractions were however present after both vaginal and transcervical insemination when the vestibule was distended, and dorsal wall of the vaginal was manually stimulated. Interestingly, this increase in uterine contractions was partially ameliorated when prostatic fluid was used as a flushing component following transcervical insemination. Two further studies performed with 72 bitches of which 18 were each inseminated transcervically with fresh or frozen semen flushed into the uterus with either saline or prostatic fluid demonstrated that prostatic fluid significantly increased the pregnancy rate and litter size of both groups. There are important mechanisms regulating the transport and elimination of sperm from the bitch's reproductive tract. Whilst physical aspects of coitus are undoubtedly involved in initiating uterine contractions, prostatic fluid appears to have an important role in modulating uterine contractions and fertility.

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Delayed uterine fluid clearance and reduced uterine perfusion in bitches with endometrial hyperplasia and clinical management with postmating antibiotic

Cited by 30 publications

References 19 publications

Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Ovarian and uterine periovulatory Doppler ultrasonography in bitches

Stimulation of Mating‐Induced Uterine Contractions in the Bitch and Their Modification and Enhancement of Fertility by Prostatic Fluid

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