2016
DOI: 10.1371/journal.pone.0164786
|View full text |Cite
|
Sign up to set email alerts
|

Delayed-Type Hypersensitivity to Metals of Environmental Burden in Patients with Takotsubo Syndrome – Is There a Clinical Relevance?

Abstract: ObjectiveTakotsubo syndrome (TS) is a heart condition characterised by a sudden transient left ventricular dysfunction; its pathophysiology is probably associated with elevated levels of catecholamines but the exact mechanism is not known as yet. Literature and clinical experience suggest that TS affects persons with various comorbidities. This pilot work aims to evaluate the frequency of comorbidities with potential pathological immune reactivity, and to evaluate the potential association between TS and hyper… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
11
0

Year Published

2018
2018
2022
2022

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 9 publications
(11 citation statements)
references
References 34 publications
0
11
0
Order By: Relevance
“…Metal hypersensitivity has been also associated with development of diverse diseases, such as nonischemic dilated cardiomyopathy [83], Takotsubo syndrome [57], connective tissue disease [56], fibromyalgia [84], and autoimmune thyroiditis [85]. In patients with diagnosed metal hypersensitivity and with health problems associated with metal medical devices, their health problems disappeared after the metal materials were removed [30,65].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Metal hypersensitivity has been also associated with development of diverse diseases, such as nonischemic dilated cardiomyopathy [83], Takotsubo syndrome [57], connective tissue disease [56], fibromyalgia [84], and autoimmune thyroiditis [85]. In patients with diagnosed metal hypersensitivity and with health problems associated with metal medical devices, their health problems disappeared after the metal materials were removed [30,65].…”
Section: Discussionmentioning
confidence: 99%
“…Memory lymphocyte immune-stimulation assay (MELISA®) is based on the evaluation of the proliferation of peripheral blood lymphocytes in vitro after incubation with metal ions. This test modification for assessment of hypersensitivity reactions to various metals or nonmetal materials is used in many laboratories [30,43,[53][54][55][56][57][58]. MELISA® test could help the surgeon in selecting the most appropriate and tolerated implant material for the patients and may benefit the performance of the implantation by decreasing postoperative complications or revision surgeries.…”
Section: Introductionmentioning
confidence: 99%
“…Heavy metals such as mercury, cadmium, and aluminum can have immunotoxic eff ects through T-cell mediated, cellular-type hypersensitivity (Type IV delayed-type hypersensitivity) [7]. Th is delayed-type hypersensitivity occurs 24 to 48 hours aft er exposure and can be diagnosed by patch test, Lymphocyte Transformation Test (LTT), identifi cation of sensitized T cells by MELISA (Memory Lymphocyte Immuno-Stimulation Assay) [21] or morphological confi rmation of the presence of activated lymphocytes (lymphoblasts) [7]. Th is delayed-type hypersensitivity to mercury occurred in 14.8% of healthy persons [21].…”
Section: Discussionmentioning
confidence: 99%
“…Th is delayed-type hypersensitivity occurs 24 to 48 hours aft er exposure and can be diagnosed by patch test, Lymphocyte Transformation Test (LTT), identifi cation of sensitized T cells by MELISA (Memory Lymphocyte Immuno-Stimulation Assay) [21] or morphological confi rmation of the presence of activated lymphocytes (lymphoblasts) [7]. Th is delayed-type hypersensitivity to mercury occurred in 14.8% of healthy persons [21]. As seen in fi gures 1 & 2 of the current study, this type of metal-induc ed "delayed" hypersensitivity or immunotoxicity makes alveolar hypoxia, an acute form of Diff use Alveolar Damage (DAD), and stimulates infl ammatory changes, cytokines productions, free radical productions, alveolar congestion, and pulmonary edema [14].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation