Delayed tear clearance in contact lens associated papillary conjunctivitis

Abstract

Tear clearance in contact lens associated papillary conjunctivitis patients was delayed. We proposed that delayed tear clearance might increase the protein and inflammatory mediator concentrations in the tear film and contribute to the pathogenesis or aggravate the severity of contact lens associated papillary conjunctivitis.

Mechanical Complications Induced by Silicone Hydrogel Contact Lenses

“…82 Contact lens-induced papillary conjunctivitis has been associated with delayed tear clearance, which might increase the protein and inflammatory mediator concentrations in the tear film and contribute to the pathogenesis or aggravate the severity of CLPC. 83 Of interest, MGD is common for patients with CLPC, 84 but no association was found between MGD and delayed tear clearance. 83 It has been proposed that a tear clearance test be incorporated in the eye examination for CL wearers with CLPC, as the treatment modality can be adjusted accordingly.…”

“…83 Of interest, MGD is common for patients with CLPC, 84 but no association was found between MGD and delayed tear clearance. 83 It has been proposed that a tear clearance test be incorporated in the eye examination for CL wearers with CLPC, as the treatment modality can be adjusted accordingly. 83 In cases of decreased tear clearance, nonpreserved steroids may be indicated.…”

“…83 It has been proposed that a tear clearance test be incorporated in the eye examination for CL wearers with CLPC, as the treatment modality can be adjusted accordingly. 83 In cases of decreased tear clearance, nonpreserved steroids may be indicated. If tear clearance is normal, then changing the lens material may be recommended first, because mechanical trauma may be a more significant contributor compared with inflammation.…”

Allergic Conjunctivitis: An Immunological Point of View

“…GPC is associated with the infiltration of basophils, eosinophils, plasma cells, and lymphocytes, which suggest a mixed mast cell-and lymphocyte-mediated process. (Chang & Chang, 2001) …”

The tear turnover and tear clearance tests – a review

“…It is suggested that the increase in MMP-9 activity may lead to corneal epithelial disease. Tear clearance is also reduced in subjects with contact lens associated papillary conjunctivitis [33]. Delayed tear clearance may be the best measure for identifying patients with tear film disorders, who may respond to anti-inflammatory therapy [3].…”