Delayed Results of Transplantation of Fetal Neurogenic Tissue in Patients with Consequences of Spinal Cord Trauma

Селедцова, Г. В.; Rabinovich, S. S.; Белогородцев, С. Н.; Parlyuk, O. V.; Селедцов, В. И.; Va, Kozlov

doi:10.1007/s10517-010-0985-1

Cited by 20 publications

(15 citation statements)

References 11 publications

(21 reference statements)

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“…In clinical studies, transplantation of neural stem cells has been applied for human cases of severe SCI; however, the therapeutic effects of NSPC transplantation are still controversial ( Harrop et al., 2012 ). Seledtsova and colleagues transplanted human-derived NSPCs into the injured spinal cords of 43 patients, and nearly half of the patients (49%) showed some functional improvement after transplantation ( Seledtsova et al., 2010 ). Although Dobkin and colleagues also transplanted human-derived NSPCs into the injured spinal cords of seven patients, none of these patients achieved a functional recovery after transplantation ( Dobkin et al., 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

et al. 2015

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SummaryNeural stem/progenitor cell (NSPC) transplantation is a promising therapeutic strategy for spinal cord injury (SCI). However, the efficacy of NSPC transplantation on severe SCI is poorly understood. We herein show that NSPC transplantation promotes functional recovery after mild and moderate SCI, but not after severe SCI. In severe SCI mice, there were few remaining host neurons within the range of NSPC engraftment; thus, we examined whether the co-distribution of transplant and host is a contributory factor for functional improvement. A cellular selective analysis using laser microdissection revealed that drug-induced host neuronal ablation considerably decreased the synaptogenic potential of the engrafted NSPCs. Furthermore, following host neuronal ablation, neuronal retrograde tracing showed less propriospinal relay connections bridging the lesion after NSPC transplantation. Our findings suggest that the interactive synaptic reorganization between engrafted NSPCs and spared host neurons is crucial for functional recovery, providing significant insight for establishing therapeutic strategies for severe SCI.

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Section: Discussionmentioning

confidence: 99%

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

et al. 2015

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“…These authors noted a correlation between neurological recovery and patient age, as the younger patients had a greater neurological improvement (67% of patients under 20 years of age improved vs 0% of those more than 50 years of age). 56 In addition, there was a greater FIM improvement in patients without intramedullary cysts (55%) than in those with a cyst (45%), which suggests that the surgical intervention and decompression of the syrinx and spinal tethering was not the origin of the neurological improvement.…”

Section: Fetal Neurogenic Tissue Transplantationmentioning

confidence: 91%

“…Nine of the 12 studies lacked a control population in their design, which resulted in a downgrading of the paper to a Grade IV. 14,23,32,35,41,46,52,56,62 There were no prospective randomized studies (Grade I or II). This lack of prospective randomization and control populations appears to be the result of several studies being performed as pilot or safety studies.…”

Section: Quality Of the Literature And Studiesmentioning

confidence: 99%

Evaluation of clinical experience using cell-based therapies in patients with spinal cord injury: a systematic review

Harrop

Hashimoto

Norvell

et al. 2012

SPI

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Object Using a systematic approach, the authors evaluated the current utilization, safety, and effectiveness of cellular therapies for traumatic spinal cord injuries (SCIs) in humans. Methods A systematic search and critical review of the literature published through mid-January 2012 was performed. Articles included in the search were restricted to the English language, studies with at least 10 patients, and those analyzing cellular therapies for traumatic SCI. Citations were evaluated for relevance using a priori criteria, and those that met the inclusion criteria were critically reviewed. Each article was then designated a level of evidence that was developed by the Oxford Centre for Evidence-Based Medicine. Results The initial literature search identified 651 relevant articles, which decreased to 350 after excluding case reports and reviews. Evaluation of articles at the title/abstract level, and later at the full-text level, limited the final article set to 12 papers. The following cellular therapies employed in humans with SCI are reviewed: bone marrow mesenchymal and hematopoietic stem cells (8 studies), olfactory ensheathing cells (2 studies), Schwann cells (1 study), and fetal neurogenic tissue (1 study). Overall the quality of the literature was very low, with 3 Grade III levels of evidence and 9 Grade IV studies. Conclusions Several different cellular-mediated strategies for adult SCI have been reported to be relatively safe with varying degrees of neurological recovery. However, the literature is of low quality and there is a need for improved preclinical studies and prospective, controlled clinical trials.

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“…Rabinovich (2003), Moviglia (2006) and Seledtsova (2010) reported that transplantation of OEC or/and BMMC combination in patients with SCI, showed some functional recovery [41,73,74]. Moviglia (2006) reported that combined protocol of cell therapy for chronic SCI by intravenous (IV) and intra-arterial (IA) showed electrical and functional recovery [46].…”

Section: Different Cell Combinationmentioning

confidence: 99%

Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Huang

Sharma

Chen

et al. 2018

Journal of Neurorestoratology

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KEYWORDS neurorestorative strategies; spinal cord injury; cell therapy; neuromodulation; nerve bridges.Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies.In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords "neurorestorative strategies", "spinal cord injury", "cell therapy", "neuromodulation", and "nerve bridges". Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.

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Delayed Results of Transplantation of Fetal Neurogenic Tissue in Patients with Consequences of Spinal Cord Trauma

Cited by 20 publications

References 11 publications

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Evaluation of clinical experience using cell-based therapies in patients with spinal cord injury: a systematic review

Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

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