Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Huang, Hongyun; Sharma, Hari Shanker; Chen, Lin; Otom, Ali; Zoubi, Ziad M. Al; Saberi, Hooshang; Mureșanu, Dafin F.; He, Xijing

doi:10.26599/jnr.2018.9040013

Cited by 22 publications

(11 citation statements)

References 64 publications

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“…Spinal cord injury (SCI) is an irremediable disease that is associated with the locomotor, sensory, and autonomic dysfunction (Carlozzi et al, 2017;Hao et al, 2017;. Within months after SCI, sensory dysfunctions, like paresthesia, dysesthesia, and chronic neuropathic pain, develops and tortures the patients day in and day out (Hao et al, 2017;Hongyun Huang et al, 2018;Hoschouer, Finseth, Flinn, Basso, & Jakeman, 2010;Kang et al, 2018;. The torture experience impairs the quality of daily life (W. Wang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

miR‐22‐3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p‐EGFR/p‐STAT3/GAP43/p‐GAP43 axis

Wang

et al. 2019

Journal Cellular Physiology

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Spinal cord injury (SCI) is a devastating disease. Strategies that enhance the intrinsic regenerative ability are very important for the recovery of SCI to radically prevent the occurrence of sensory disorders. Epidermal growth factor (EGF) showed a limited effect on the growth of primary sensory neuron neurites due to the degradation of phosphorylated-epidermal growth factor receptor (p-EGFR) in a manner dependent on Casitas B-lineage lymphoma (CBL) (an E3 ubiquitin-protein ligase). MiR-22-3p predicted from four databases could target CBL to inhibit the expression of CBL, increase p-EGFR levels and neurites length via STAT3/GAP43 pathway rather than Erk1/2 axis. EGF, EGFR, and miR-22-3p were downregulated sharply after injury. In vivo miR-22-3p Agomir application could regulate CBL/p-EGFR/p-STAT3/GAP43/p-GAP43 axis, and restore spinal cord sensory conductive function. This study clarified the mechanism of the limited promotion effect of EGF on adult primary sensory neuron neurite and targeting miR-22-3p could be a novel strategy to treat sensory dysfunction after SCI. K E Y W O R D Scasitas b-lineage lymphoma, epidermal growth factor, epidermal growth factor receptor, miR-22-3p, primary sensory neuron, spinal cord injury

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Section: Introductionmentioning

confidence: 99%

miR‐22‐3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p‐EGFR/p‐STAT3/GAP43/p‐GAP43 axis

Wang

et al. 2019

Journal Cellular Physiology

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“…Clinical neurorestorative treatments for patients with SCI have made enormous strides in recent years [20,2,158]. This guideline definitely can provide new knowledge and information to physicians in treating patients with SCI.…”

Section: Discussionmentioning

confidence: 99%

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)

Huang

Young

Skaper

et al. 2020

Journal of Orthopaedic Translation

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Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, “Clinical Therapeutic Guidelines of Neurorestoration for Spinal Cord Injury (China Version 2016)” was first proposed in 2016 by the Chinese Association of Neurorestoratology (CANR). Given the rapid advances in this field in recent years, the International Association of Neurorestoratology (IANR) and CANR formed and approved the “Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)”. These guidelines mainly introduce restoring damaged neurological structure and functions by varying neurorestorative strategies in acute, subacute, and chronic phases of SCI. These guidelines can provide a neurorestorative therapeutic standard or reference for clinicians and researchers in clinical practice to maximally restore functions of patients with SCI and improve their quality of life.The translational potential of this articleThis guideline provided comprehensive management strategies for SCI, which contains the evaluation and diagnosis, pre-hospital first aid, treatments, rehabilitation training, and complications management. Nowadays, amounts of neurorestorative strategies have been demonstrated to be benefit in promoting the functional recovery and improving the quality of life for SCI patients by clinical trials. Also, the positive results of preclinical research provided lots of new neurorestorative strategies for SCI treatment. These promising neurorestorative strategies are worthy of translation in the future and can promote the advancement of SCI treatments.

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“…At the same time, more clinical trials of evidencebased medical evidence are needed [63]. Most of the experimental studies have focused on the recovery of motor function in rats, with less attention to other dysfunctions such as neuropathic pain, bladder dysfunction, and spasm [64].…”

Section: Discussionmentioning

confidence: 99%

The cell repair research of spinal cord injury: a review of cell transplantation to treat spinal cord injury

Zhang

Wang

Song

2019

Journal of Neurorestoratology

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Through retrospective analysis of the literature on the cell repair of spinal cord injury worldwide, it is found that the mechanism of cell transplantation repairing spinal cord injury is mainly to replace damaged neurons, protect host neurons, prevent apoptosis, promote axonal regeneration and synapse formation, promote myelination, and secrete trophic factors or growth factors to improve microenvironment. A variety of cells are used to repair spinal cord injury. Stem cells include multipotent stem cells, embryonic stem cells, and induced pluripotent stem cells. The multipotent stem cells are mainly various types of mesenchymal stem cells and neural stem cells. Non-stem cells include olfactory ensheathing cells and Schwann cells. Transplantation of inhibitory interneurons to alleviate neuropathic pain in patients is receiving widespread attention. Different types of cell transplantation have their own advantages and disadvantages, and multiple cell transplantation may be more helpful to the patient’s functional recovery. These cells have certain effects on the recovery of neurological function and the improvement of complications, but further exploration is needed in clinical application. The application of a variety of cell transplantation, gene technology, bioengineering and other technologies has made the prospect of cell transplantation more extensive. There is a need to find a safe and effective comprehensive treatment to maximize and restore the patient’s performance.

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Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Cited by 22 publications

References 64 publications

miR‐22‐3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p‐EGFR/p‐STAT3/GAP43/p‐GAP43 axis

miR‐22‐3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p‐EGFR/p‐STAT3/GAP43/p‐GAP43 axis

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)

The cell repair research of spinal cord injury: a review of cell transplantation to treat spinal cord injury

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