Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men

Mood and autonomic responses to repeated exposure to the Trier Social Stress Test for Groups (TSST-G)

“…This indicates a stronger affective stress sensitivity of this group. In accordance with our findings from the TSST-G-2 nd -defence group, previous measurements of sAA revealed no habituation to repeated application (Wüst et al, 2005;von Känel et al, 2006). Nevertheless, we observed a reduced response in the subversion with the TSST-G-2 ndpresentation, suggesting that the defensive speech was experienced as more stressful.…”

“…During the second exposure to the TSST-G, a significant increase in HR was detected. Previous studies about the repeated application of the TSST in single settings showed, similarly, no habituation with regard to the HR response (Gerra et al, 2001;von Känel et al, 2006;Jönsson et al, 2010) or a minimal decrease over time (Schommer et al, 2003). In the present study, the repeated application showed no (TSST-G-2 nd -defence) or a slight (TSST-G-2 nd -presentation) habituation with regard to HR.…”

“…Repeated exposure to the TSST has produced different changes in various physiological stress systems. The cortisol response usually habituates to repeated exposure to minimally changed stress tasks (Kirschbaum et al, 1995;Schommer et al, 2003;Wüst et al, 2005;Kudielka et al, 2006), whereas the stress response of sAA (Gerra et al, 2001;Schommer et al, 2003;, HR (Gerra et al, 2001;Schommer et al, 2003;von Känel et al, 2006;Jönsson et al, 2010) and HRV (Petrowski et al, 2012) show very little habituation to repeated stress exposure.…”

Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers

“…Vagal regulation of immune reactivity has been proposed as a pathway linking psychosocial factors to risk for inflammatory processes including atherosclerosis (Marsland et al 2007;Tracey 2002), which we may on the basis of the present data extend to the postulate of a neurovisceral integration model implying other physiological systems as well (Thayer and Sternberg 2006). Regarding IL-6, there were no significant changes at all which parallels a number of other (Kop et al 2008;Miller et al 2005;Dugué et al 1993;Lutgendorf et al 2004;Heinz et al 2003;Heesen et al 2002) but not all authors (Edwards et al 2006;von Känel et al 2006;Brydon et al 2005;Steptoe et al 2001).…”

Factores psicobiológicos en vitiligo infantil: Posible rol en su génesis e impacto en la calidad de vida

“…3) Existe una alta concordancia entre el alza de mediadores séricos durante estados de ansiedad o durante la respuesta fisiológica al estrés mental con los mediadores postulados como patogénicos en vitiligo. Estos incluyen a la norepinefrina 8,28,29,30 , epinefrina, cortisol 31,32,33 , IL-6 34,35 , TNF-alfa 36,37 , betaendorfina 38,39 . En general, los autores de estos reportes atribuyen un efecto tóxico a las catecolaminas contra los melanocitos y queratinocitos, fundamentalmente a través de la producción de metabolitos tóxicos y radicales libres.…”