Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks

Matson, M. Jeremiah; Chertow, Daniel S.; Munster, Vincent J.

doi:10.1080/22221751.2020.1722036

Cited by 20 publications

(22 citation statements)

References 59 publications

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“…The epidemics of Ebola fever and acquired immunodeficiency syndrome (AIDS) in West Africa are also thought to be linked to Se deficiency ( Melse et al, 2007 ; Steinbrenner et al, 2015 ). In addition, Se deficiency affects the physical development of children’s immune systems, which has led to immune impairment of adolescents in Africa ( Ramanathan & Taylor 1997 ; Matson et al, 2020 ). Given that Se is apparently strongly linked to diseases, how exactly does it affect them?…”

Section: Relationship Of Se Status With Diseases and The Immune Systementioning

confidence: 99%

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Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

Liu

Zhao

et al. 2021

Environmental Research

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Host nutrition is an important factor affecting disease progression. Selenium (Se) is an essential trace element for the human body with anti-inflammatory, antioxidant, and immune effects, and Se deficiency increases RNA-virus replication and virulent mutations, which lead to more severe tissue damage and symptoms. Low Se status in the host may be an important cause of health complications induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this article, we describe the metabolic mechanisms by which Se is involved in anti-inflammatory, antioxidant, and immune effects, and review the role and clinical effects of Se in viral infection. We then discuss the potential relationship between Se and coronavirus disease 2019 (COVID-19). The association between soil Se level and the incidence of COVID-19 was observed in different cities of Hubei Province. The incidence of COVID-19 was more than 10 times lower in Se-enriched cities (Enshi, Shiyan, and Xiangyang) than in Se-deficient cities (Suizhou and Xiaogan). Although the relationship between soil Se levels and the incidence of COVID-19 in Hubei still needs further study, these findings provide baseline information demonstrating the effect of Se levels on SARS-CoV-2, which could contribute to the prevention and management of COVID-19.

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Section: Relationship Of Se Status With Diseases and The Immune Systementioning

confidence: 99%

“…The Ebola virus is a filamentous, unsegmented, negative-sense RNA virus of the family Filoviridae and can cause hemorrhagic fever ( Matson et al, 2020 ). It has attracted worldwide attention due to its multiple outbreaks in Africa.…”

Section: Overview Of the Relationship Between Se And Rna Virusesmentioning

confidence: 99%

Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

Liu

Zhao

et al. 2021

Environmental Research

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“…An EBOV is a single-stranded, non-segmented, and negativesense RNA virus. EBOVs were discovered during an outbreak of EVD in the Democratic Republic of Congo in 1976 [32,33]. EVD is characterized by severe acute symptomatology, including high fevers, arthralgia, severe fatigue; hemorrhagic manifestations such as oozing and acute bleeding occur in the final stages.…”

Section: Ebola Virus Diseasementioning

confidence: 99%

“…With other filoviruses, EBOVs can be transmitted from an animal reservoir or intermediate host to a primary human case in a single zoonotic spillover event. The primary case then initiates the person-to-person transmission [32]. The contact situations and monitoring of infected patients as well as their families and neighbors are crucial for controlling an EVD outbreak [33].…”

Section: Ebola Virus Diseasementioning

confidence: 99%

COVID-19 Compared with Other Viral Diseases: Novelties, Progress, and Challenges

Wang

Alexander

2020

Electron J Gen Med

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COVID-19 is a newly discovered, highly infectious disease and has rapidly spread into at least 213 countries as a pandemic. This paper is a comprehensive review article of COVID-19 and four other viral diseases, including influenza, Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Ebola virus disease (EVD). The cause of COVID-19 is the novel coronavirus-SARS-CoV-2. The transmission of COVID-19 is complex and rapid; therefore, it is difficult to control the spread of the disease. Certified specific antiviral drugs are slowly becoming available for COVID-19, although a few treatments such as Remdesivir, hydroxychloroquine, dexamethasone, and therapeutic plasma exchange (TPE) have been found somewhat effective. Effective vaccines are still in the process of development and several countries, including the USA are conducting Phase 3 trials currently to fast-track the vaccines. All these issues have created significant challenges in reducing the morbidity and mortality of this global infectious disease. COVID-19 has led to vast impacts on public health and the global economy. With economic shutdowns, social distancing, increased handwashing, and sanitizing have been first line therapies for mitigating the spread of COVID-19 and have created a new normal. COVID-19 is different from influenza and previous pandemic diseases, such as SARS, MERS, and EVD, but has some similarities to them. Influenza and these pandemic diseases are introduced in this paper as a comparison with COVID-19. The features of COVID-19, progress achieved in treatment, emerging technologies in testing and diagnosis, and current and future challenges are presented. Specifically, topics regarding COVID-19 in this paper cover basic facts, the questionable origin of COVID-19, testing and diagnosis, pharmaceutical treatment and comfort measures, strategies and management for fighting against COVID-19, and the emotional, psychological, and mental health impacts of shelter-in-place orders and quarantine of COVID-19.

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“…The genus Ebolavirus consists of six species: Taï Forest ebolavirus (Taï Forest virus, TAFV), Reston ebolavirus (Reston virus, RESTV), Sudan ebolavirus (Sudan virus, SUDV), Bundibugyo ebolavirus (Bundibugyo virus, BDBV), Bombali ebolavirus (putatively Bombali virus, BOMV) and Zaire ebolavirus (Ebola virus, EBOV) [ 4 , 5 ]. Among these, EBOV is studied most intensively as it is the main circulating pathogenic ebolavirus found in infected patients in the majority of outbreaks [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties

Stahelin

2020

Viruses

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Viral protein 24 (VP24) from Ebola virus (EBOV) was first recognized as a minor matrix protein that associates with cellular membranes. However, more recent studies shed light on its roles in inhibiting viral genome transcription and replication, facilitating nucleocapsid assembly and transport, and interfering with immune responses in host cells through downregulation of interferon (IFN)-activated genes. Thus, whether VP24 is a peripheral protein with lipid-binding ability for matrix layer recruitment has not been explored. Here, we examined the lipid-binding ability of VP24 with a number of lipid-binding assays. The results indicated that VP24 lacked the ability to associate with lipids tested regardless of VP24 posttranslational modifications. We further demonstrate that the presence of the EBOV major matrix protein VP40 did not promote VP24 membrane association in vitro or in cells. Further, no protein–protein interactions between VP24 and VP40 were detected by co-immunoprecipitation. Confocal imaging and cellular membrane fractionation analyses in human cells suggested VP24 did not specifically localize at the plasma membrane inner leaflet. Overall, we provide evidence that EBOV VP24 is not a lipid-binding protein and its presence in the viral matrix layer is likely not dependent on direct lipid interactions.

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Delayed recognition of Ebola virus disease is associated with longer and larger outbreaks

Cited by 20 publications

References 59 publications

Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

COVID-19 Compared with Other Viral Diseases: Novelties, Progress, and Challenges

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties

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