Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

Liu, Qiyuan; Zhao, Xiaoli; Ma, Jin; Mu, Yunsong; Wang, Ying; Shi, Yang; Wu, Yihang; Wu, Fengchang; Zhou, Yongzhang

doi:10.1016/j.envres.2021.110984

Cited by 40 publications

(27 citation statements)

References 60 publications

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“… Kumar et al (2021) performed a temporal study on SARS-CoV-2 RNA detection and need for the escalation, to unravel the early warning capability of wastewater surveillance for COVID-19. Liu et al (2021a) showed implications for COVID-19 related to the fact that selenium plays a key role in the biological effects of some viruses. Liu et al (2021b) reported the data of a study on the role of seasonality in the spread of COVID-19 pandemic, whereas Mahanta et al (2021) conducted a performance study of a sterilization box, using a combination of heat and ultraviolet light irradiation for the prevention of COVID-19.…”

Section: Comments On Papers Published In the Virtual Speciasll Issuementioning

confidence: 99%

SARS-CoV-2 and other pathogenic microorganisms in the environment

Núñez‐Delgado¹,

Bontempi

Coccia

et al. 2021

Environmental Research

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The title of the Virtual Special Issue (VSI) “SARS-CoV-2 and other pathogenic microorganisms in the environment”, clearly indicates a main focus not only on the virus causing the current pandemic, but also on other pathogenic microorganisms and their spatial and temporal dynamics in environmental compartments. Overall, the VSI has received more than 100 submissions relating to most of the possible fields connected to the pandemic, many of them of high scientific value. A rigorous peer-reviewing process has been carried out, with a panel of experts making a great work to evaluate that important number of submissions. As a result, those manuscripts reaching the highest scientific standards were selected for publication. We think that the papers included constitute a set of high-quality contributions, which should help to improve the overall scientific perspective regarding this crucial issue. In this piece, the Editors comment some issues on the papers accepted for publication, and include additional reflections.

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Section: Comments On Papers Published In the Virtual Speciasll Issuementioning

confidence: 99%

SARS-CoV-2 and other pathogenic microorganisms in the environment

Núñez‐Delgado¹,

Bontempi

Coccia

et al. 2021

Environmental Research

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“…[69][70][71] Other minerals such as selenium have been found to have antiviral effects against COVID-19. 72,73…”

Section: Metallodrugs For the Treatment Of Human Viral Diseasesmentioning

confidence: 99%

Metallomics for the Screening of COVID-19 and Metallodrug Development

Zhao¹,

Wang²,

Li-wei³

et al. 2021

At.Spectrosc.

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The COVID-19 pandemic has led to severe threat globally. As a result, scientists are increasing their efforts in developing testing methods, antiviral drugs, and vaccines, to diagnose, treat, and defend against COVID-19 respectively. Although RT-PCR and antigen tests are used for the screening of COVID-19, there are many disadvantages including high cost, long processing time, and false-negative results. With the exception of supportive care, no specific treatment for COVID-19 has been established. Metallomics focuses on the systematic study of the interactions and functional connections of metallic/metalloid ions and their species with genes, proteins, metabolites, and other biomolecules within organisms and ecosystems. It has been applied in the screening of various cancers, neurodegenerative diseases, and viral infections and metallodrug development with the advantages of high throughput, low risk of cross-infection, low cost, and ready availability. Therefore, we proposed the use of metallomics for the screening and metallodrug development of COVID-19. An operational work scheme is also presented.

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“…As part of this minireview, we shall therefore provide some essential information about this fascinating and in many aspects unique proteinogenic amino acid, from its biosynthesis in plants and metabolism in yeast to its ability to replace Met in proteins and its role as a food supplement. From the onset, we would like to emphasize that we have focused on some of the more recent and exciting discoveries in this field and therefore shall refer to the existing literature for more basic information [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases

et al. 2021

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Selenium is an essential trace element. Although this chalcogen forms a wide variety of compounds, there are surprisingly few small-molecule organic selenium compounds (OSeCs) in biology. Besides its more prominent relative selenocysteine (SeCys), the amino acid selenomethionine (SeMet) is one example. SeMet is synthesized in plants and some fungi and, via nutrition, finds its way into mammalian cells. In contrast to its sulfur analog methionine (Met), SeMet is extraordinarily redox active under physiological conditions and via its catalytic selenide (RSeR’)/selenoxide (RSe(O)R’) couple provides protection against reactive oxygen species (ROS) and other possibly harmful oxidants. In contrast to SeCys, which is incorporated via an eloquent ribosomal mechanism, SeMet can enter such biomolecules by simply replacing proteinogenic Met. Interestingly, eukaryotes, such as yeast and mammals, also metabolize SeMet to a small family of reactive selenium species (RSeS). Together, SeMet, proteins containing SeMet and metabolites of SeMet form a powerful triad of redox-active metabolites with a plethora of biological implications. In any case, SeMet and its family of natural RSeS provide plenty of opportunities for studies in the fields of nutrition, aging, health and redox biology.

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Selenium (Se) plays a key role in the biological effects of some viruses: Implications for COVID-19

Cited by 40 publications

References 60 publications

SARS-CoV-2 and other pathogenic microorganisms in the environment

SARS-CoV-2 and other pathogenic microorganisms in the environment

Metallomics for the Screening of COVID-19 and Metallodrug Development

Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases

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