Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm

Nievas, Mario N. Carvi y; Archavlis, Eleftherios; Unkel, B.

doi:10.1179/016164109x12581096870113

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Recently, a cohort of just seven paediatric patients with eight peripheral nerve tumours has been published [ 16 ]. Furthermore, purely larger paediatric series do not exist; in mixed series, paediatric cases are not evaluated separately [ 6 – 9 , 18 , 21 , 27 ]. Due to the rare nature of peripheral nerve sheath tumours in children and its association with rare genetic pathologies like neurofibromatosis, only limited data exists.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of peripheral nerve sheath tumours in children, with special consideration of neurofibromatoses

et al. 2020

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Introduction Peripheral nerve sheath tumours in children are a rare and heterogeneous group, consisting mostly of benign tumours as well as malignant neoplasms. Especially in the paediatric population, diagnostics and indication for therapy pose relevant challenges for neurosurgeons and paediatric neurologists alike. Most paediatric cases that need surgical intervention are associated to neurofibromatosis type 1 (NF1). Methods We retrospectively reviewed all paediatric cases treated at the Department of Neurosurgery in Tübingen between 2006 and 2017 for peripheral nerve sheath tumours. We analysed clinical signs, symptoms, histology, association to an underlying phacomatosis and sensory/motor function. Results Of the 82 identified patients, the majority had NF1 (76.8%). Nine children bore a sporadic tumour without underlying phacomatosis (11%), 8 had NF2 (9.8%) and 2 schwannomatosis (2.4%), A total of 168 surgical interventions were performed, and 206 tumours were removed. Indication for surgery was in most instances significant tumour growth (45.2%) followed by pain (33.9%). New deficits led to surgery in 12.5% of interventions; malignancy was suspected in 8.3%. Histopathology revealed mostly neurofibromas (82.5%), divided into cutaneous neurofibromas (10.7%), infiltrating plexiform neurofibromas (25.7%) and peripheral nerve-born neurofibromas (46.1%). 12.1% of tumours were schwannomas, 2.9% MPNST, 1.5% ganglioneuroma (n = 3) and 1 hybrid-neurofibroma and perineurinoma each. Leading symptoms, such as pain and motor and sensory deficits, improved after 125/166 interventions (74.4%), remained unchanged following 39 interventions (23.2%) and worsened in 4 occasions (2.4%). Conclusion Surgery is safe and effective for (neurofibromatosis associated) peripheral nerve sheath tumours in the paediatric population; however, management needs a multidisciplinary setting. We propose early surgical resection in paediatric patients with peripheral nerve sheath tumours with significant growth, or pain, or motor deficit, or suspected malignancy.

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Section: Discussionmentioning

confidence: 99%

Surgical management of peripheral nerve sheath tumours in children, with special consideration of neurofibromatoses

et al. 2020

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“…The aim of surgical treatment of a symptomatic schwannoma is total to gross total excision of the tumor along with preservation of the affected nerve and its function, particularly in patients with conserved functionality of a major nerve trunk. 2 , 4 Techniques for endoscopic resection of schwannomas have been reported. 1 , 3 The purpose of this Technical Note is to describe the details of nerve-preserving endoscopically assisted resection of a schwannoma of the radial nerve of the arm.…”

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Nerve-Preserving Endoscopically Assisted Resection of Schwannoma of the Radial Nerve

Lui¹,

Li²

2020

Arthroscopy Techniques

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Schwannomas are the most common peripheral nerve tumors; they can present as painful masses or paresthesia. The aim of surgical treatment of a symptomatic schwannoma is total to gross total excision of the tumor along with preservation of the affected nerve and its function, particularly in patients with conserved functionality of a major nerve trunk. This Technical Note describes the technical details of nerve-preserving endoscopically assisted resection of a schwannoma of the radial nerve. This is an intracapsular resection of the tumor, and the risk of nerve injury is minimized.

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Das Schwannom des Nervus femoralis

Schulte

Sandalcioglu²,

Grabellus³

et al. 2013

Schmerz

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Delayed outcome from surgically treated patients with benign nerve associated tumors of the extremities larger than 5 cm

Cited by 7 publications

References 19 publications

Surgical management of peripheral nerve sheath tumours in children, with special consideration of neurofibromatoses

Surgical management of peripheral nerve sheath tumours in children, with special consideration of neurofibromatoses

Nerve-Preserving Endoscopically Assisted Resection of Schwannoma of the Radial Nerve

Das Schwannom des Nervus femoralis

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