Delayed Manipulation Following Clostridial Collagenase Histolyticum Injection for Dupuytren Contracture

Kaplan, F. Thomas D.; Badalamente, Marie A.; Hurst, Lawrence C.; Merrell, Gregory A.; Pahk, Raymond

doi:10.1016/j.jhsa.2013.08.084

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…According to the initial studies, the finger extension procedure should be performed the day after the injection, but recent studies show that a delay of up to 7 days after injection gives equivalent results [ 63 , 64 ]. Both the EMA and FDA have approved manipulation up to 72 hours later.…”

Section: Practical Guidance From Experienced Surgeonsmentioning

confidence: 99%

See 1 more Smart Citation

Collagenase Clostridium histolyticum:emerging practice patterns and treatment advances

Warwick

Arandes-Renú

Pajardi

et al. 2016

Journal of Plastic Surgery and Hand Surgery

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Objective: This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). Methods: This review is based on a literature review and practical experience. Results: This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. Conclusion: CCH has an evolving role as one of the tools available for treating Dupuytren's disease.

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Section: Practical Guidance From Experienced Surgeonsmentioning

confidence: 99%

“…The finger extension procedure is typically performed the day after the CCH injection. In the recent MULTICORD study the extension procedure was delayed until 48 or 72 hours without any difference in the efficacy or safety profile [ 63 , 64 ].…”

Section: Technical Advancesmentioning

confidence: 99%

Collagenase Clostridium histolyticum:emerging practice patterns and treatment advances

Warwick

Arandes-Renú

Pajardi

et al. 2016

Journal of Plastic Surgery and Hand Surgery

View full text Add to dashboard Cite

show abstract

“…En caso de gran reacción inflamatoria local por la inyección de la CCH o por fracaso de la anestesia, la extensión del dedo se puede posponer a más de 24 h La extensión del dedo se puede realizar entre los 2 y 4 días sin que aumenten los ES 31,32 .…”

Section: Nuevos Estudiosunclassified