Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants

Abstract

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants (Review)

Extended minimal enteral feeding and time to regain birth weight in extremely low-birth-weight infants

“…Furthermore, our findings are consistent with the results of a recent meta-analysis of 1551 very lowbirth-weight infants, which found that delaying the introduction of progressive enteral feeds beyond four days after birth may not reduce the risk of NEC or death [16]. We also could not detect a significant difference in NEC development or death before the discharge between an extended MEF at > 72 h and early progressive feeding.…”

Extended minimal enteral feeding and time to regain birth weight in extremely low-birth-weight infants

“…Furthermore, our findings are consistent with the results of a recent meta-analysis of 1551 very lowbirth-weight infants, which found that delaying the introduction of progressive enteral feeds beyond four days after birth may not reduce the risk of NEC or death [16]. We also could not detect a significant difference in NEC development or death before the discharge between an extended MEF at > 72 h and early progressive feeding.…”

Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants

“…Thus, we anticipated that a sample size of 3142 patients (786 infants exposed to early achievement of full enteral feeding and 2356 infants unexposed) would have a 90% power to detect a 6% absolute risk reduction in culture-proven sepsis or death at a P < .05 significance level. This estimated risk reduction falls within the range reported in meta-analyses of clinical trials on early feeding practices (2%-10%) and in observational studies from developed countries (6%-10%) …”

“…Although we could not characterize the specific strategies applied in each NICU to favor the early establishment of full enteral feeding, these findings are broadly consistent with results from meta-analyses summarizing the effects of earlier and more rapid advancement of enteral feeding volumes . The meta-analysis on early progression of enteral feeding that included EPT infants along with very preterm infants (28-32 weeks of gestation) demonstrated that early achievement of full enteral feeding reduced the risk of severe infection (22% vs 31%; RR, 0.70; 95% CI, 0.56-0.87; n = 872; P = .001), the use of parenteral nutrition, and the length of hospital stay .…”

“…An increasing body of evidence has highlighted the advantages of early achievement of full enteral feeding. Notably, contrary to longstanding concerns, early enteral feeding with human milk has not been associated with a higher risk of NEC in meta-analyses of randomized clinical trials of daily advancement of enteral feeding volumes before or on postnatal day 4 (early progression of enteral feeding) and rapid advancement of enteral feeding volumes by 30 to 40 mL/kg/d (faster progression of enteral feeding) …”

Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth

“…A comprehensive systematic review recently concluded that the effects of early progression of feeding on long-term growth or neurodevelopment are unknown [8]. Our findings provide low- to moderate-quality evidence that early feeding progression does not increase the risk of adverse long-term outcomes.…”

Extended minimal enteral feeding and time to regain birth weight in extremely low-birth-weight infants

“…Furthermore, our findings are consistent with the results of a recent meta-analysis of 1551 very lowbirth-weight infants, which found that delaying the introduction of progressive enteral feeds beyond four days after birth may not reduce the risk of NEC or death [16]. We also could not detect a significant difference in NEC development or death before the discharge between an extended MEF at > 72 h and early progressive feeding.…”

Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants

“…Thus, we anticipated that a sample size of 3142 patients (786 infants exposed to early achievement of full enteral feeding and 2356 infants unexposed) would have a 90% power to detect a 6% absolute risk reduction in culture-proven sepsis or death at a P < .05 significance level. This estimated risk reduction falls within the range reported in meta-analyses of clinical trials on early feeding practices (2%-10%) and in observational studies from developed countries (6%-10%) …”

“…Although we could not characterize the specific strategies applied in each NICU to favor the early establishment of full enteral feeding, these findings are broadly consistent with results from meta-analyses summarizing the effects of earlier and more rapid advancement of enteral feeding volumes . The meta-analysis on early progression of enteral feeding that included EPT infants along with very preterm infants (28-32 weeks of gestation) demonstrated that early achievement of full enteral feeding reduced the risk of severe infection (22% vs 31%; RR, 0.70; 95% CI, 0.56-0.87; n = 872; P = .001), the use of parenteral nutrition, and the length of hospital stay .…”

“…An increasing body of evidence has highlighted the advantages of early achievement of full enteral feeding. Notably, contrary to longstanding concerns, early enteral feeding with human milk has not been associated with a higher risk of NEC in meta-analyses of randomized clinical trials of daily advancement of enteral feeding volumes before or on postnatal day 4 (early progression of enteral feeding) and rapid advancement of enteral feeding volumes by 30 to 40 mL/kg/d (faster progression of enteral feeding) …”

Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth

“…A comprehensive systematic review recently concluded that the effects of early progression of feeding on long-term growth or neurodevelopment are unknown [8]. Our findings provide low- to moderate-quality evidence that early feeding progression does not increase the risk of adverse long-term outcomes.…”

Extended minimal enteral feeding and time to regain birth weight in extremely low-birth-weight infants

“…Furthermore, our findings are consistent with the results of a recent meta-analysis of 1551 very lowbirth-weight infants, which found that delaying the introduction of progressive enteral feeds beyond four days after birth may not reduce the risk of NEC or death [16]. We also could not detect a significant difference in NEC development or death before the discharge between an extended MEF at > 72 h and early progressive feeding.…”

Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants

“…Thus, we anticipated that a sample size of 3142 patients (786 infants exposed to early achievement of full enteral feeding and 2356 infants unexposed) would have a 90% power to detect a 6% absolute risk reduction in culture-proven sepsis or death at a P < .05 significance level. This estimated risk reduction falls within the range reported in meta-analyses of clinical trials on early feeding practices (2%-10%) and in observational studies from developed countries (6%-10%) …”

“…Although we could not characterize the specific strategies applied in each NICU to favor the early establishment of full enteral feeding, these findings are broadly consistent with results from meta-analyses summarizing the effects of earlier and more rapid advancement of enteral feeding volumes . The meta-analysis on early progression of enteral feeding that included EPT infants along with very preterm infants (28-32 weeks of gestation) demonstrated that early achievement of full enteral feeding reduced the risk of severe infection (22% vs 31%; RR, 0.70; 95% CI, 0.56-0.87; n = 872; P = .001), the use of parenteral nutrition, and the length of hospital stay .…”

“…An increasing body of evidence has highlighted the advantages of early achievement of full enteral feeding. Notably, contrary to longstanding concerns, early enteral feeding with human milk has not been associated with a higher risk of NEC in meta-analyses of randomized clinical trials of daily advancement of enteral feeding volumes before or on postnatal day 4 (early progression of enteral feeding) and rapid advancement of enteral feeding volumes by 30 to 40 mL/kg/d (faster progression of enteral feeding) …”

Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth

“…A comprehensive systematic review recently concluded that the effects of early progression of feeding on long-term growth or neurodevelopment are unknown [8]. Our findings provide low- to moderate-quality evidence that early feeding progression does not increase the risk of adverse long-term outcomes.…”