Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images: an experimental study in rat livers with gadolinium chloride-induced Kupffer cell damage

Furuta, Tadahiko; Yamaguchi, Masayuki; Nakagami, Ryutaro; Akahane, Masaaki; Minami, Manabu; Ohtomo, Kuni; Moriyama, Noriyuki; Fujii, Hirofumi

doi:10.1007/s10334-012-0354-3

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Possibly, the elimination of Kupffer cell function by thermal ablation may be associated with the difference. 23 As shown in Figure 6, autoradiography demonstrated the intense 59 Fe accumulation in the fibrous capsule than ablated liver tissues (the inner core). Prussian blue-stained specimen demonstrated the large number , respectively) of HE-stained liver section of the same rat.…”

Section: Discussionmentioning

confidence: 95%

Magnetic Resonance-Based Visualization of Thermal Ablative Margins Around Hepatic Tumors by Means of Systemic Ferucarbotran Administration Before Radiofrequency Ablation

Nagai

Yamaguchi

Mori

et al. 2015

Investigative Radiology

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Section: Discussionmentioning

confidence: 95%

Magnetic Resonance-Based Visualization of Thermal Ablative Margins Around Hepatic Tumors by Means of Systemic Ferucarbotran Administration Before Radiofrequency Ablation

Nagai

Yamaguchi

Mori

et al. 2015

Investigative Radiology

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“…[ 39 ] Patients who are lighter or have liver and kidney function abnormalities who are not carefully evaluated before surgery, may be given overdosed anesthetic drugs, which may lead to high drug concentration in the body and DR. [ 40 ] If the operation time is very long and the evaluation of the end of the operation is biased, the anesthesia duration will be too long accordingly, [ 41 ] which is also an important factor for occurrence of DR from anesthesia. It must be noted that patients with lower body temperature who enter the recovery room after surgery are more likely to develop DR. [ 42 ] Drops in body temperature may decrease the activity of enzymes related to drug metabolism, which may cause drugs to accumulate in the body and patients experience DR. [ 43 ]…”

Section: Discussionmentioning

confidence: 99%

“…It must be noted that patients with lower body temperature who enter the recovery room after surgery are more likely to develop DR [42] . Drops in body temperature may decrease the activity of enzymes related to drug metabolism, which may cause drugs to accumulate in the body and patients experience DR [43] …”

Section: Discussionmentioning

confidence: 99%

Risk factors of delayed recovery from general anesthesia in patients undergoing radical biliary surgery

Zhang¹,

Pan²,

Tan³

et al. 2021

Medicine

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Delayed recovery (DR) is very commonly seen in the patients undergoing laparoscopic radical biliary surgery, we aimed to investigate the potential risk factors of DR in the patients undergoing radical biliary surgery, to provide evidences into the management of DR. Patients who underwent radical biliary surgery from January 1, 2018 to August 31, 2020 were identified. The clinical characteristics and treatment details of DR and no-DR patients were compared and analyzed. Multivariable logistic regression analyses were conducted to identify the potential influencing factors for DR in patients with laparoscopic radical biliary surgery. We included a total of 168 patients with laparoscopic radical biliary surgery, the incidence of postoperative DR was 25%. There were significant differences on the duration of surgery, duration of anesthesia, and use of intraoperative combined sevoflurane inhalation (all P < .05), and there were not significant differences on American Society of Anesthesiologists, New York Heart Association, tumor-lymph node- metastasis, and estimated blood loss between DR group and control group (all P > .05). Multivariable logistic regression analyses indicated that age ≥70 years (odd ratio [OR] 1.454, 95% confidence interval [CI] 1.146–1.904), body mass index ≥25 kg/m 2 (OR 1.303, 95% CI 1.102–1.912), alcohol drinking (OR 2.041, 95% CI 1.336–3.085), smoking (OR 1.128, 95% CI 1.007–2.261), duration of surgery ≥220 minutes (OR 1.239, 95% CI 1.039–1.735), duration of anesthesia ≥230 minutes (OR 1.223, 95% CI 1.013–1.926), intraoperative combined sevoflurane inhalation (OR 1.207, 95% CI 1.008–1.764) were the independent risk factors for DR in patients with radical biliary surgery (all P < .05). It is clinically necessary to take early countermeasures against various risk factors to reduce the occurrence of DR, and to improve the prognosis of patients.

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“…Nonparenchymal cells, including HSCs, liver sinusoidal endothelial cells, Kupffer cells, and biliary epithelial cells, 14 play important roles during radiation-induced liver injury and fibrosis. 15,16 These cells secrete a variety of cytokines that is involved in liver injury and repair, wherein HSC activation is the main link to hepatic fibrosis. 17 Therefore, we hypothesize that a similar mechanism might be involved in radiation-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

“…Nonparenchymal cells, including HSCs, liver sinusoidal endothelial cells, Kupffer cells, and biliary epithelial cells, 14 play important roles during radiation‐induced liver injury and fibrosis 15,16 . These cells secrete a variety of cytokines that is involved in liver injury and repair, wherein HSC activation is the main link to hepatic fibrosis 17 .…”

Section: Discussionmentioning

confidence: 99%

Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury

Xiao

Zhang

Yang

et al. 2020

The Kaohsiung J of Med Scie

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Transforming growth factor‐β1 (TGF‐β1) is one of critical cytokines in radiation‐induced liver injury. Hepatic stellate cells (HSC) are activated in the early stage of radiation‐induced liver injury. However, it is currently unclear whether phosphatidylinositol 3‐kinase (PI3K/Akt) signal pathway is activated in radiation‐induced liver injury. Herein, male Sprague‐Dawley rats were irradiated with 6 MV X‐rays (30 Gy) on the right liver. Next, Hematoxylin and eosin staining, Masson staining, and electron microscopy were performed to examine pathological changes. Immunohistochemistry was performed to assess the expression of TGF‐β1, α‐SMA, and p‐Akt (S473) in liver tissues. In vitro, rat HSC cell line HSC‐T6 cells were given different doses of 6 MV X‐ray irradiation (10 and 20 Gy) and treated with LY294002. The expression of α‐SMA and p‐Akt in mRNA and protein levels were measured by reverse transcription‐polymerase chain reactioin (RT‐PCR) and Western blot. TGF‐β1 expression was detected by enzyme‐linked immuno sorbent assay (ELISA). After irradiation, the liver tissues showed obvious pathological changes, indicating the establishment of the radiation‐induced liver injury. Expression levels of TGF‐β1, α‐SMA, and p‐Akt (S473) protein in liver tissues were significantly increased after irradiation, and this increase was in a time‐dependent manner, suggesting the activation of HSC and PI3K/Akt signal pathway. in vitro experiments showed that the TGF‐β1 secreted by HSCs, and the expression of Akt and α‐SMA at mRNA and protein levels were significantly increased in irradiation groups. However, the expression of TGF‐β1, Akt, and α‐SMA were significantly decreased in PI3K/Akt signal pathway inhibitor LY294002‐treated group. Our results suggest that during radiation‐induced liver injury, HSCs are activated by TGF‐β1‐mediated PI3K/Akt signal pathway.

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Delayed hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images: an experimental study in rat livers with gadolinium chloride-induced Kupffer cell damage

Abstract: Hepatic signal recovery on ferucarbotran-enhanced MRI was delayed in the context of GdCl3-induced KC damage due to increased hepatic iron deposits. Hepatic signal recovery may be used as a clinical marker of KC damage in liver disorders, including radiation-induced hepatitis.

Cited by 5 publications

References 17 publications

Magnetic Resonance-Based Visualization of Thermal Ablative Margins Around Hepatic Tumors by Means of Systemic Ferucarbotran Administration Before Radiofrequency Ablation

Magnetic Resonance-Based Visualization of Thermal Ablative Margins Around Hepatic Tumors by Means of Systemic Ferucarbotran Administration Before Radiofrequency Ablation

Risk factors of delayed recovery from general anesthesia in patients undergoing radical biliary surgery

Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury

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