Delayed Effects of Acute Deltamethrin Toxicity on Brain and Blood Monoamines and Free Amino Acids: Therapeutic Role of Selenium-Supplementation

Oxidative stress and neuromodulatory effects of deltamethrin and its combination with insect repellents in rats

“…DEL is a neurotoxic compound, and it alters neurotransmitters of brain and blood levels of serotonin, dopamine, noradrenaline and adrenaline, and acetylcholinesterase activity. 39 The positive and negative mood is mainly mediated by serotonin and dopamine. 40 The increased and decreased levels of dopamine are responsible for positive and negative mood, respectively.…”

Evaluation of changes in monoamine levels and apoptosis induced by cyfluthrin in rats

“…Similar results were previously reported for 5-HT levels in rat brain exposed to a single acute dose of deltamethrin. 19 The administration of cyhalothrin to rats at the dose levels of 10, 20 and 60 mg kg −1 caused dose-dependent increases of striatal 5-HT, but no changes were seen in the outflow of 5-HIAA. 20 In a study aimed at determining the effect of permethrin on striatum, median prefrontal cortex and hippocampal monoamine levels, a statistically insignificant increase in 5-HT levels was found in the study group treated with 34 mg kg −1 permethrin, whereas the 5-HIAA levels remained unchanged.…”

“…In the current study, plasma E and NE levels were significantly reduced and plasma 5-HT levels were also significantly increased in the experimental group. Overall, studies of pyrethroid insecticides have produced inconsistent results; many studies show both an increase 25,26 and a decrease 19,27 in E and NE levels.…”