Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy

Teraoka, Kunihiko; Hirano, Masaharu; Ookubo, Hiroyuki; Sasaki, Kohsuke; Katsuyama, Hiroaki; Amino, Masayuki; Abe, Yimihiko; Yamashina, Akira

doi:10.1016/j.mri.2003.08.009

Cited by 150 publications

(76 citation statements)

References 28 publications

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“…LGE mass and LGE extent in patients with and without non-sustained ventricular tachycardia on ECG Holter monitoring [7]. On the contrary, there are studies indicating significant difference in LGE extent between groups of patients with and without ventricular tachycardia [10,11]. These discrepancies might be a result of utilizing different methods for LGE quantification [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, there are studies indicating significant difference in LGE extent between groups of patients with and without ventricular tachycardia [10,11]. These discrepancies might be a result of utilizing different methods for LGE quantification [10,11]. Recently, we described significant variability of LGE mass quantified with the use of various methods [8].…”

Section: Discussionmentioning

confidence: 99%

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Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Śpiewak¹,

Małek²,

Chojnowska³

et al. 2010

Int J Cardiovasc Imaging

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To quantify heterogeneous tissue at the periphery of areas of fibrosis (gray zone) in patients with hypertrophic cardiomyopathy (HCM) with the use of two different techniques. Cardiac magnetic resonance with late gadolinium enhancement analysis was performed in 33 patients with HCM. Gray zone was evaluated with the use of two different techniques previously described in patients after myocardial infarction. LGE was present in 25 (78%) patients. There was no significant difference in total LGE mass at two different cut-off values [53.8 g (interquartile range, IQR 43.5-77.8 g) vs. 53.8 g (IQR 37.8-64.5 g), respectively, P = 0.49]. Significant difference in gray zone mass assessed with the use of two techniques was demonstrated (19.1 +/- 7.3 g vs. 50.8 +/- 47.8 g; P = 0.003). There was a strong correlation between total LGE and gray zone mass (r = 0.789, P = 0.0001 for first method and r = 0.951, P < 0.0001 for the second one, respectively). However, significant variability of gray zone mass (and extent expressed as % of left ventricular mass) in patients with similar LGE size/extent was observed. Moreover, LGE mass varied greatly in patients with similar gray zone size. Neither left ventricular mass, nor with maximal wall thickness correlated with extent of gray zone assessed with both methods. The studied techniques provided similar results with regard to total LGE but significant differences were observed in gray zone mass. Two patients may have similar extent (or absolute mass) of LGE, but strikingly discrepant gray zone size.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Śpiewak¹,

Małek²,

Chojnowska³

et al. 2010

Int J Cardiovasc Imaging

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“…Areas of DHE (scarring) on MRI have been shown to correlate with histologically proven myocardial fibrosis [23]. However, there are minimal data to determine whether or not the presence of myocardial scar detected by DE-MRI is associated with VT or SCD [13,24,25]. We sought to determine the association between interventricular septal thickness, myocardial scar and VT, as documented on arrhythmia monitoring.…”

mentioning

confidence: 99%

Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study

Kwon

Setser

Popović

et al. 2008

Int J Cardiovasc Imaging

111

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“…The technique has largely contributed to the assessment of the left ventricle as myocardial infarction, fibrosis, and inflammation cause characteristic patterns of delayed contrast enhancement [48,49,50]. The presence of delayed contrast enhancement on MRI images was also described in patients with PH [51] (fig.…”

Section: Mri Applications In the Characterisation Of Ph Patientsmentioning

confidence: 99%

The Emerging Role of Magnetic Resonance Imaging in the Diagnosis and Management of Pulmonary Hypertension

Kovàcs

Reiter

et al. 2008

Respiration

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Pulmonary hypertension is a life-threatening chronic disorder of the pulmonary circulation. Elevated pressure and resistance in the pulmonary vessels lead to progressive right heart failure which results in functional limitations and ultimately the death of most patients. Thus, the monitoring of right ventricular (RV) function is of great importance. Cardiac magnetic resonance imaging (cardiac MRI) has several advantages over other imaging methods. The use of cine acquisition techniques allows precise description of characteristic volumetric and functional variables, such as right ventricular volumes, muscle mass, stroke volume, ejection fraction, or cardiac output. Impaired right ventricular contractility and function have also been assessed using measures like ventricular septal bowing and pressure-volume loops. MRI investigations have been performed to monitor medical treatment, and the improvement in well-established prognostic factors, such as the 6-min walk, were correlated with measures of right ventricular function. Flow-derived parameters of the pulmonary arteries (such as peak velocity, acceleration time and volume, or pulmonary flow profile) are available using velocity-encoded imaging, and may detect early signs of remodelling. Additionally, magnetic resonance angiography is a promising new tool to visualise pulmonary perfusion and to diagnose chronic thromboembolic pulmonary hypertension. The purpose of this review is to summarise recent advances of cardiovascular magnetic resonance imaging, which will play an increasing role in the comprehensive diagnostic work-up of patients with pulmonary hypertension as a tool to monitor the course of the disease and to evaluate new therapeutic approaches.

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Delayed contrast enhancement of MRI in hypertrophic cardiomyopathy

Cited by 150 publications

References 28 publications

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Late gadolinium enhancement gray zone in patients with hypertrophic cardiomyopathy. Comparison of different gray zone definitions

Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study

The Emerging Role of Magnetic Resonance Imaging in the Diagnosis and Management of Pulmonary Hypertension

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