Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study

Kwon, Deborah; Setser, Randolph M.; Popović, Zoran B.; Sola, Srikanth; Schoenhagen, Paul; García, Mario J.; Flamm, Scott D.; Lever, Harry M.; Desai, Milind Y.

doi:10.1007/s10554-008-9292-6

Cited by 111 publications

(62 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3) [13]. The role of LGE on CMR for the prediction of major adverse outcomes such as SCD, arrhythmias, systolic and diastolic HF may be supported by some emerging data [14][15][16].…”

Section: Detection Of Myocardial Fibrosis With Late Gadolinium Enhancmentioning

confidence: 95%

“…A myocardial scar mass of more than 7 g on LGE predicted the risk of developing ventricular tachycardia with 75% sensitivity and 82% specificity. Kwon et al [16] independently confirmed an increased frequency of arrhythmias using Holter monitoring. It was reported that a greater percentage of patients with LGE had documented arrhythmias compared to those without LGE (27% vs. 5%, p = 0.03).…”

Section: Late Gadolinium Enhancement and Arrhythmiasmentioning

confidence: 95%

See 1 more Smart Citation

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

2016

View full text Add to dashboard Cite

show abstract

“…3) [13]. The role of LGE on CMR for the prediction of major adverse outcomes such as SCD, arrhythmias, systolic and diastolic HF may be supported by some emerging data [14][15][16].…”

Section: Detection Of Myocardial Fibrosis With Late Gadolinium Enhancmentioning

confidence: 95%

Section: Late Gadolinium Enhancement and Arrhythmiasmentioning

confidence: 95%

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

2016

View full text Add to dashboard Cite

show abstract

“…33,34 Late gadolinium enhancement has also been associated with ventricular arrhythmia on Holter monitoring. 35 Nonetheless, LGE has not yet been established as a criterion for the placement of an implantable defibrillator in patients with hypertrophic cardiomyopathy. 20 …”

Section: A B Cmentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging for the Investigation of Cardiovascular Disorders. Part 1: Current Applications

Goenka

Wang

Flamm

2014

Texas Heart Institute Journal

Self Cite

View full text Add to dashboard Cite

Cardiac magnetic resonance imaging is a robustC ardiac magnetic resonance imaging (CMR) has emerged as a robust noninvasive technique for the investigation of cardiovascular disorders. Several technical advances have facilitated the growth of CMR by enabling high-quality diagnostic imaging despite the challenges inherent to cardiac imaging: cardiorespiratory motion and flowing blood. Considerable research evidence and years of clinical experience have shown the diagnostic and prognostic usefulness of CMR in a wide spectrum of cardiovascular disorders. The coming-of-age of CMR and its widening span of applications have generated excitement, as well as uncertainty, regarding its potential clinical use and its role vis-à-vis conventional imaging techniques. The purpose of this article is to highlight the current (Part 1) and emerging (Part 2) applications of CMR, in order to assist the referring physician in the decision-making process. Current Applications Analysis of Ventricular Function and VolumesCardiac magnetic resonance imaging has evolved into an accurate and well-validated tool for the evaluation of cardiac function. The high reproducibility of CMR-derived measures of cardiac function makes CMR an ideal technique for the longitudinal follow-up of patients.1 This superior reproducibility has also led to increased use of CMR as a reference standard for other techniques and as a surrogate outcome measure in drug studies. In fact, the use of CMR has facilitated reduction in the required sample sizes for such studies by as much as 10-fold, in turn decreasing overall study costs by up to 80%. 2-4Cardiac-function evaluation on CMR is based on true volumetric quantification, which is performed by dividing the ventricles into several smaller and relatively simpler subvolumes for the calculation of global ventricular volume (the disc-summation technique). This technique does not use the geometric assumptions that form the basis of planar imaging techniques like echocardiography. The current workhorse of functional CMR is the balanced steady-state free precession (SSFP) sequence, which provides excellent delineation of the endocardial-blood pool interface. When combined with parallel imaging techniques, the SSFP sequence enables the acquisition of electrocardiographic (ECG)-gated images within breath-hold times as short as 6 seconds per slice while maintaining sufficient spatial resolution. Images are acquired in the true short-axis plane from the base of the heart to the apex (Fig. 1). For image

show abstract

“…Late gadolinium enhancement (LGE) sequences enable the identification of myocardial fibrosis, which is associated with poor outcome. 3 The scarring seen in hypertrophic obstructive cardiomyopathy(HCM) is of mixed type i.e. replacement, interstitial and plexiform type with overlapping patterns which alone cannot be differentiated from scarring seen in other types of cardiomyopathies seen as late gadolinium enhancements(LGE's).…”

Section: Introductionmentioning

confidence: 99%

Swiss Cheese Myocardium: A Diagnostic and Prognostic Sign of HCM by Newer CMR Techniques

Singh¹,

Kapoor²,

Mahajan³

2017

JCDR

View full text Add to dashboard Cite

Cardiac MR(CMR) has an important role in the evaluation of patients of suspected cardiomyopathies and also helps to differentiate between the various types based on the type of late gadolinium enhancements(LGE's). We describe a characteristic Swiss cheese myocardium appearance in a patient with hypertrophic cardiomyopathy (HCM) using automatic scar analysis algorithm using low < 2SD scale threshold weighting to assess the replacement and interstitial fibrosis along with T1 mapping to quantify it.

show abstract

Association of myocardial fibrosis, electrocardiography and ventricular tachyarrhythmia in hypertrophic cardiomyopathy: a delayed contrast enhanced MRI study

Abstract: HCM subjects with VT have a higher % of myocardial scarring noted on DHE-MRI, independent of septal thickness or beta-blocker use.

Cited by 111 publications

References 43 publications

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

Cardiovascular magnetic resonance imaging in hypertrophic cardiomyopathy: Current state of the art

Cardiac Magnetic Resonance Imaging for the Investigation of Cardiovascular Disorders. Part 1: Current Applications

Swiss Cheese Myocardium: A Diagnostic and Prognostic Sign of HCM by Newer CMR Techniques

Contact Info

Product

Resources

About