Delayed Argon Administration Provides Robust Protection Against Cardiac Arrest-Induced Neurological Damage

Brücken, Anne; Kurnaz, Pınar; Berne, Christian; Derwall, Matthias; Weis, Joachim; Nolte, Kay; Rossaint, Rolf; Fries, Michael

doi:10.1007/s12028-014-0029-1

Cited by 29 publications

(42 citation statements)

References 27 publications

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“…In rodents, Brücken et al showed that the administration of argon 1 h after cardiac arrest improved functional neurological recovery after experimental cardiac arrest [6,19]. The same result was observed when argon was administered 3 h after cardiac arrest [20]. Pigs receiving post-resuscitation treatment with argon also had complete neurological recovery [7].…”

Section: Discussionmentioning

confidence: 86%

Argon attenuates multiorgan failure following experimental aortic cross‐clamping

Savary

Lidouren

Rambaud

et al. 2018

Brit J Clinical Pharma

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Section: Discussionmentioning

confidence: 86%

Argon attenuates multiorgan failure following experimental aortic cross‐clamping

Savary

Lidouren

Rambaud

et al. 2018

Brit J Clinical Pharma

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“…The noble gases Ar and Xe have also previously been investigated as a reconditioning strategy in IRI kidney transplant models showing beneficial effects on graft function 1213. But since the protective effect of Ar seems to be dose-dependent,14 a higher and longer exposure to Ar to protect against pulmonary ischemia reperfusion injury seemed justified. A prolonged exposure to Ar can be achieved by introducing the gas earlier in the process of organ donation 15.…”

Section: Introductionmentioning

confidence: 99%

A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury

et al. 2017

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Argon (Ar) is a noble gas with known organoprotective effects in rodents and in vitro models. In a previous study we failed to find a postconditioning effect of Ar during ex vivo lung perfusion (EVLP) on warm-ischemic injury in a porcine model. In this study, we further investigated a prolonged exposure to Ar to decrease cold ischemia-reperfusion injury after lung transplantation in a porcine model with EVLP assessment. Domestic pigs (n = 6/group) were pre-conditioned for 6 hours with 21% O2 and 79% N2 (CONTR) or 79% Ar (ARG). Subsequently, lungs were cold flushed and stored inflated on ice for 18 hours inflated with the same gas mixtures. Next, lungs were perfused for 4 hours on EVLP (acellular) while ventilated with 12% O2 and 88% N2 (CONTR group) or 88% Ar (ARG group). The perfusate was saturated with the same gas mixture but with the addition of CO2 to an end-tidal CO2 of 35-45 mmHg. The saturated perfusate was drained and lungs were perfused with whole blood for an additional 2 hours on EVLP. Evaluation at the end of EVLP did not show significant effects on physiologic parameters by prolonged exposure to Ar. Also wet-to-dry weight ratio did not improve in the ARG group. Although in other organ systems protective effects of Ar have been shown, we did not detect beneficial effects of a high concentration of Ar on cold pulmonary ischemia-reperfusion injury in a porcine lung model after prolonged exposure to Ar in this porcine model with EVLP assessment.

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“…Histopathological damage in the cortex and hippocampal region was reduced, resulting in an improved functional neurological outcome up to 3 days after injury. This improvement was even shown by applying argon 1 delayed hour after CPR GABAA receptor gamma-aminobutyric acid A receptor; LPS lipopolysaccharide; ERK1/2 extracellular signal-regulated kinases 1/2; MEK1/2 = MAPKK mitogen-activated protein kinase; mTOR mammalian target of rapamycin; Nrf2 nuclear factor (erythroid-derived 2)-like 3; TLR Toll-like receptor; NF-κB nuclear factor "kappa-light-chainenhancer" of activated B cells [110,111]. Following these promising results, argon was added to mild hypothermia in the same model.…”

Section: Neuroprotection By Argonmentioning

confidence: 99%

Update of the organoprotective properties of xenon and argon: from bench to beside

Röhl

Rossaint

Coburn

2020

ICMx

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The growth of the elderly population has led to an increase in patients with myocardial infarction and stroke (Wajngarten and Silva, Eur Cardiol 14: 111-115, 2019). Patients receiving treatment for ST-segment-elevation myocardial infarction (STEMI) highly profit from early reperfusion therapy under 3 h from the onset of symptoms. However, mortality from STEMI remains high due to the increase in age and comorbidities (Menees et al., N Engl J Med 369: 901-909, 2013). These factors also account for patients with acute ischaemic stroke. Reperfusion therapy has been established as the gold standard within the first 4 to 5 h after onset of symptoms (Powers et al., Stroke 49: e46-e110, 2018). Nonetheless, not all patients are eligible for reperfusion therapy. The same is true for traumatic brain injury patients. Due to the complexity of acute myocardial and central nervous injury (CNS), finding organ protective substances to improve the function of remote myocardium and the ischaemic penumbra of the brain is urgent. This narrative review focuses on the noble gases argon and xenon and their possible cardiac, renal and neuroprotectant properties in the elderly high-risk (surgical) population. The article will provide an overview of the latest experimental and clinical studies. It is beyond the scope of this review to give a detailed summary of the mechanistic understanding of organ protection by xenon and argon.

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Delayed Argon Administration Provides Robust Protection Against Cardiac Arrest-Induced Neurological Damage

Cited by 29 publications

References 27 publications

Argon attenuates multiorgan failure following experimental aortic cross‐clamping

Argon attenuates multiorgan failure following experimental aortic cross‐clamping

A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury

Update of the organoprotective properties of xenon and argon: from bench to beside

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