Argon attenuates multiorgan failure following experimental aortic cross‐clamping

Savary, Guillaume; Lidouren, Fanny; Rambaud, Jérôme; Kohlhauer, Matthias; Hauet, Thierry; Bruneval, Patrick; Costes, Bruno; Cariou, Alain; Ghaleh, Bijan; Tissier, Renaud

doi:10.1111/bcp.13535

Cited by 10 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, various studies investigating the indirect effects of IR on the small intestine using abdominal aortic clamping have found that IR is the result of the loss of villus epithelia. [25,26] In the present study, we observed intestinal ulceration due to intestinal epithelial loss. We also observed hemorrhage and the degeneration of intestinal crypts in subepithelial connective tissue.…”

Section: Discussionsupporting

confidence: 59%

The Protective Effect of Adalimumab on Intestinal Injury induced with Infrarenal Aortic Occlusion

Pergel

Tümkaya

Demiral

et al. 2019

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND: The present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. METHODS: A total of 24 male Sprague-Dawley rats were randomly divided into three groups-a control group, an IR group and an IR+ADA group. RESULTS: Although there was no change in SOD levels in the small bowel tissue of the IR group, we observed increased malondialdehyde (MDA) levels and increased numerical density of caspase-3 and TNF-α positive enterocytes p=0.00 and p=0.00, respectively). We also observed that IR caused the degeneration of villus crypt structures. CONCLUSION: We found that ADA treatment reduced MDA levels and decreased the numerical density of caspase-3 and TNF-α positive enterocytes compared to the IR group (p=0.00; p=0.011; p=0.00, respectively). We conclude that ADA can be beneficial in preventing intestinal injury that arises from IR.

show abstract

Section: Discussionsupporting

confidence: 59%

The Protective Effect of Adalimumab on Intestinal Injury induced with Infrarenal Aortic Occlusion

Pergel

Tümkaya

Demiral

et al. 2019

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…Although the mechanism involved in pulmonary tissue damage following aortic occlusion is not fully understood, studies have shown that oxidative stress, in which an increase in ROS production and a decrease in antioxidant enzyme activation occur, may be the cause [ 11 , 24 ] . Kurtoglu et al [ 25 ] determined that aortic occlusion resulted in an increase in myeloperoxidase and MDA levels in serum and lung tissue.…”

Section: Discussionmentioning

confidence: 99%

Tea Grape Reduces Abdominal Aortic Occlusion-Induced Lung Injury

Hemsinli¹,

Ergene²,

Karakişi³

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Introduction Ischemia-associated mortality caused by aortic cross-clamps, as in ruptured abdominal aorta aneurysm surgeries, and reperfusion following their removal represent some of the main emergency conditions in cardiovascular surgery. The purpose of our study was to examine the potential protective effect of tea grape against aortic occlusion-induced lung injury using biochemical, histopathological, immunohistochemical, and quantitative analyses. Methods Thirty-two male Sprague-Dawley rats were randomly assigned into four groups: control (healthy), glycerol + ischemia/reperfusion (I/R) (sham), I/R, and I/R + tea grape. Results Following aortic occlusion, we observed apoptotic pneumocytes, thickening in the alveolar wall, edematous areas in interstitial regions, and vascular congestion. We also observed an increase in pulmonary malondialdehyde (MDA) levels and decrease in pulmonary glutathione (GSH). However, tea grape reduced apoptotic pneumocytes, edema, vascular congestion, and MDA levels, while increased GSH levels in lung tissue. Conclusion Our findings suggest that tea grape is effective against aortic occlusion-induced lung injury by reducing oxidative stress and apoptosis.

show abstract

“…Previous studies have reported that abdominal I/R causes apoptosis in renal cells in addition to an increase in ROS [ 12 , 28 ] . In their study involving an aortic cross-clamping model in rats, Oyar et al [ 25 ] showed that in addition to increasing MDA levels in kidney tissue, I/R also led to apoptosis in renal tubule cells by increasing activity of Caspase-3, one of the caspases involved in the irreversible terminal stage of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Ergene¹,

Hemsinli²,

Karakişi³

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Objective: To examine the biochemical and histopathological renal effects of ischemia/reperfusion (I/R) injury using a ruptured abdominal aortic aneurysm (RAAA) model in rats and to investigate the potential protective effects of whortleberry (Vaccinium myrtillus). Methods: Thirty-two male Sprague-Dawley rats were randomly assigned into four groups-control, sham (I/R+glycerol), I/R, and I/ R+whortleberry. Midline laparotomy alone was performed in the control group. Atraumatic abdominal clamps were attached under anesthesia to the abdominal aorta beneath the level of the renal artery in the groups subjected to I/R. Sixty-minute reperfusion was established one hour after ischemia. The sham group received five intraperitoneal doses of glycerol five days before I/R. The I/ R+whortleberry group received a single intraperitoneal 50 mg/kg dose diluted with saline solution five days before I/R. All animals were finally euthanized by cervical dislocation following 60-min reperfusion. Results: Increases were observed in malondialdehyde (MDA) levels and tubular necrosis scores (TNS) in thin kidney tissues and in numbers of apoptotic renal tubule cells, together with a decrease in glutathione (GSH) levels, in sham and I/R groups. In contrast, we observed a decrease in MDA levels, TNS, and numbers of apoptotic renal tubule cells, and an increase in GSH levels with whortleberry treatment compared to the I/R group. Conclusion: Our findings suggest that whortleberry may be effective against acute kidney injury by reducing oxidative stress and apoptosis.

show abstract

Argon attenuates multiorgan failure following experimental aortic cross‐clamping

Abstract: Argon attenuated clinical and biological modifications of cardiovascular, renal and intestinal systems, but not the inflammatory response, after aortic cross-clamping. The window of administration was crucial to optimize organ protection.

Cited by 10 publications

References 27 publications

The Protective Effect of Adalimumab on Intestinal Injury induced with Infrarenal Aortic Occlusion

The Protective Effect of Adalimumab on Intestinal Injury induced with Infrarenal Aortic Occlusion

Tea Grape Reduces Abdominal Aortic Occlusion-Induced Lung Injury

The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Contact Info

Product

Resources

About