The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Ergene, Şaban; Hemsinli, Dogus; Karakişi, Sedat Ozan; Mercantepe, Tolga; Tümkaya, Levent; Yılmaz, Adnan

doi:10.21470/1678-9741-2019-0121

Cited by 2 publications

(2 citation statements)

References 31 publications

(53 reference statements)

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“…Bilberry has been reported to reduce oxidative stress developing in tissues such as the kidney, ovary, and retina in various experimental models (17,26,27). In addition, Jakesevic et al reported that BB reduced oxidative stress-related intestinal inflammation and mucosal damage resulting from ischemia-reperfusion, and Widen reported that it ameliorated gingival inflammation (28,29).…”

Section: Histopathological Resultsmentioning

confidence: 99%

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The Ameliorating Effects of Bilberry on Methotrexate-Induced Intestinal Injury

KERİMOĞLU,

BİLGİN,

KERİMOĞLU

et al. 2023

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: Methotrexate (MTX) is a folic acid analogue chemotherapeutic used in the treatment of some malignant tumors and autoimmune diseases. In addition to its antitumoral properties, it can also exhibit toxic effects on the kidney and intestines. Bilberry (BB) fruit is a potent natural antioxidant rich in anthocyanidins. The purpose of this study was to investigate the potential ameliorating effects of BB against MTX-induced intestinal damage using biochemical and histological methods. Material and Methods: Twenty-one adult female Sprague Dawley rats were divided into three equal groups. No procedure was performed on the control group (ControlG), while the MTX group (MTXG) and MTX+BB extract group (MTX+BBG) received a single intraperitoneal dose of 30 mg/kg MTX on the first day of the experiment. MTX+BBG also received 200 mg/kg BB extract by oral gavage once daily for five days starting on the first day of the experiment. Half the intestinal tissues removed from the duodenal region at the experiment were used for biochemical evaluation, and the other half for histological examination. Results: Malondialdehyde (MDA), total oxidant status (TOS), oxidative stress index (OSI), and 8-oxo-2′-deoxyguanosine (8- OHdG) values were all higher in MTXG intestinal tissues than in ControlG. MDA, TOS, OSI, and 8-OHdG values were lower in MTX+BBG than in MTXG. In addition, caspase-3 levels in MTXG were higher than those in both ControlG and MTX+BBG, while total antioxidant status (TAS) values were lower. In terms of histology, villous hemorrhage, inflammatory cell infiltration, fusion, and degeneration in the villus epithelium were present in MTXG intestinal tissue, and the total damage score was also high. Improvement in all these parameters was present in MTX+BBG. Conclusion: Orally administered BB extract can improve MTX-induced intestinal damage through its antioxidant and anti-inflammatory effects.

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Section: Histopathological Resultsmentioning

confidence: 99%

“…It contains numerous antioxidant compounds, including quercetin, resveratrol, catechins, vitamin C, phenolic acid, and anthocyanins (13,15). Due to these compounds, and particularly anthocyanins, BB exhibits antioxidant and anti-inflammatory effects (13,16,17).…”

Section: Introductionmentioning

confidence: 99%

The Ameliorating Effects of Bilberry on Methotrexate-Induced Intestinal Injury

KERİMOĞLU,

BİLGİN,

KERİMOĞLU

et al. 2023

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis

Bilen

Mercantepe

Tümkaya

et al. 2021

J Biochem & Molecular Tox

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The mortality rate in ruptured abdominal aortic aneurysms can today be reduced through cardiovascular surgery. However, ischemia and reperfusion‐induced tissue damage develop due to aortic cross‐clamping applied during surgery. The present study aimed to reduce oxidative stress‐induced hepatic damage resulting from ischemia and reperfusion due to aortic cross‐clamping during surgery by means of resveratrol administration. Forty male Sprague–Dawley rats were randomly assigned into four groups: control (healthy), glycerol+ischemia/reperfusion (I/R) (sham), I/R, and I/R + Resveratrol. In all groups scheduled for I/R, 60 min of shock was followed by 60 min of ischemia. In the I/R + Resveratrol group, 10 mg/kg of resveratrol was administered 15 min before ischemia and immediately before reperfusion via the intraperitoneal route. In addition, 120 min of reperfusion was applied under anesthesia after ischemia in all groups. Intralobar and interlobar necrosis, vascular congestion, and edematous fields resulting from aortic occlusion were present. Liver tissue malondialdehyde (MDA) levels and cleaved caspase‐3 positivity increased, while glutathione (GSH) levels decreased. However, resveratrol administration reduced intralobular and interlobar necrosis, vascular congestion and edematous fields, cleaved caspase‐3 positivity, and MDA levels, and increased GSH levels. Our findings suggest that resveratrol is effective against aortic occlusion‐induced liver injury by reducing oxidative stress and apoptosis.

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The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm

Cited by 2 publications

References 31 publications

The Ameliorating Effects of Bilberry on Methotrexate-Induced Intestinal Injury

The Ameliorating Effects of Bilberry on Methotrexate-Induced Intestinal Injury

The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis

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