Dehydroepiandrosterone sulphate in breast secretions

Miller, William R.; Humeniuk, V.; Kelly, Regis B.

doi:10.1016/0022-4731(80)90185-5

Cited by 26 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher levels of testosterone were present in breast fluids from premenopausal breast cancer patients, but there were no differences in estrogen or prolactin levels from those in normal women. Miller et al (31) found dehydroepiandrosterone sulfate (DHEAS) to be in very high concentration in breast fluid (up to 300 times that of blood); they were unable to determine if DHEAS was locally synthesized by the breast or derived from plasma. They suggested that DHEAS serves as a precursor for testosterone, and that DHEAS concentration differs in women with differing risks of cancer as suggested by Bulbrook et al (46).…”

Section: Hormones In Breast Fluidmentioning

confidence: 97%

Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid

Petrakis

1986

Breast Cancer Res Tr

101

View full text Add to dashboard Cite

Section: Hormones In Breast Fluidmentioning

confidence: 97%

Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid

Petrakis

1986

Breast Cancer Res Tr

101

View full text Add to dashboard Cite

“…Recent studies have emphasized the free and bound fmctions of estradiol (E2) in relation to sex-hormone-binding globulin (SHBG) and plasma albumin in serum (Bruning et al, 1985;Moore et al, 1982;Reed et al, 1983; Siiteri et al, 1981 Siiteri et al, , 1986. The findings were, however, conflicting and their significance for breast cancer risk remains controversial.In other studies of the target organ itself, breast tumor tissue (Cortes-Gallegos et al, 1975; Deshpande et al, 1976; Duvivier et al, 198 1 ;Thijssen et al, 1986;van Landeghem et al, 1981), cyst fluid (Angeli et al, Bradlow et al, 1979) and nipple aspirate fluid were examined for hormonal content (Hill et al, 1983;Miller and Forrest, 1983;Miller et al, 1980Miller et al, , 1981Wynder and Hill, 1977). When compared with blood, aspirates of breast cyst fluids and tumor tissue have been reported to contain elevated levels of corticosteroids, thyroid hormones (T3 and T4), thyroid binding globulin (TBG), prolactin and a variety of estrogens and androgens.…”

mentioning

confidence: 99%

Influence of pregnancy and lactation on serum and breast fluid estrogen levels: Implications for breast cancer risk

et al. 1987

Intl Journal of Cancer

121

View full text Add to dashboard Cite

We investigated estrogen (estrone and estradiol) levels in serum and in nipple aspirates of breast fluid in relation to reproductive and menopausal characteristics in 104 normal women. In general, breast fluid and serum estrogen levels were not correlated and breast fluid estrogen levels were approximately 5 to 45 times higher than serum levels. Serum estrogen levels were lower in post-menopausal than in pre-menopausal women. In contrast, breast fluid estrogen levels were approximately the same in pre- and post-menopausal women. Breast fluid estrogen mean levels were lower in pre-menopausal parous women than in nulligravidous or nulliparous women whereas serum estrogen levels did not differ in these 3 groups. Breast fluid estrogen levels were positively correlated with months since last birth or since last breast-feeding. Estrogen levels were low in nipple aspirates of breast milk but gradually increased in breast fluid of non-lactating women over a period of several years after cessation of lactation. Serum estrogen levels did not increase with months since last breast-feeding. We were unable to evaluate the post-partum effect of pregnancy without lactation due to the small numbers of these subjects. The high concentrations of estrogen in breast fluid and the absence of a relationship to serum estrogen levels may explain why prior serum studies have failed to link variations in serum estrogens with breast cancer risk. The prolonged low levels of breast fluid estrogens following full-term birth and lactation may, in part, provide a mechanism by which parity reduces breast cancer risk.

show abstract

“…As DHAS is able to cross the cyst wall, diffusion from the surrounding tissues into the cyst must be considered together with possible synthesis by the cells of the cyst wall (Bradlow et al, 1983). High levels of DHA and DHAS have been found in normal breast nipple aspirate (Miller et al, 1980). This and the above observations suggest an important role of these hormones in the metabolic processes of normal and pathological breast cells.…”

Section: Discussionmentioning

confidence: 44%

“…It has been linked to prolactin (Angeli et al, 1982) and potassium (Bradlow et al, 1983) but the reason for the high levels in cyst fluid remain unknown. High levels of DHA and DHAS have been found in normal breast nipple aspirate (Miller et al, 1980). High levels of DHA and DHAS have been found in normal breast nipple aspirate (Miller et al, 1980).…”

Section: Discussionmentioning

confidence: 96%

Plasma and Cyst Fluid Levels of A5 and A4 Steroid Hormones in Women With Gross Cystic Breast Disease

Inaudi

Bernabei

Gioffrè

et al. 1987

Clinical Endocrinology

View full text Add to dashboard Cite

delta 5 and delta 4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean +/- SEM) of DHA (11.2 +/- 2.4 ng/ml), DHAS (1.45 +/- 0.6 micrograms/ml) and cortisol 277 +/- 15.7 ng/ml) was found; in follicular phase the mean levels were 4.09 +/- 0.47 ng/ml for DHA, 0.65 +/- 0.08 microgram/ml for DHAS and 190 +/- 46.3 micrograms/ml for cortisol. The DHA/DHAS and cortisol/androstenedione ratios were significantly higher in the plasma and lower in the cyst fluid of GCBD patients, than in the plasma of controls; the androstenedione/DHA ratio was higher in the cyst fluid than in the plasma of controls. The hormonal situation of the GCBD patients thus differed from that of the controls both in the plasma and cyst fluid, particularly as regards the delta 5 steroids.

show abstract

Dehydroepiandrosterone sulphate in breast secretions

Cited by 26 publications

References 10 publications

Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid

Physiologic, biochemical, and cytologic aspects of nipple aspirate fluid

Influence of pregnancy and lactation on serum and breast fluid estrogen levels: Implications for breast cancer risk

Plasma and Cyst Fluid Levels of A5 and A4 Steroid Hormones in Women With Gross Cystic Breast Disease

Contact Info

Product

Resources

About