Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner

Alzheimer?s disease: the impact of age-related changes in reproductive hormones

“…DHEA immunomodulatory activity also has been demonstrated in microglial cells. DHEA and DHEAS treatment prevented microglial activation by lipopolysaccharides (LPS) and beta amyloid (Ab), resulting in a reduction in reactive nitrite production [73]. This effect appears to be post-translational in microglial cells, as mRNA levels for iNOS and the activity of NF-kB were unaffected by DHEA or DHEAS treatment.…”

Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia

“…The present studies demonstrated that resveratrol significantly inhibited the expression of iNOS induced by LPS in microglia, providing a direct basis for the mechanism of action of resveratrol to reduce the NO production, which were consistent with the published paper [27]. However, it is reported that dehydroepiandrosterone inhibits LPS induction of iNOS protein, but not inhibits LPS-induced iNOS mRNA in microglial cells, suggesting that estrogen activation regulates nitrite production through a post-transcriptional mechanism [28]. Since there are some structural similarities of resveratrol to estrogenic compounds, it could not exclude, therefore, the possibility that resveratrol exerts its activities might be through the estrogen receptors to affect the cellular responses [29,30].…”

Down regulation of interleukin-1β-induced nitric oxide production in lacrimal gland acinar cells by sex steroids

“…28 DHEA and DHEA-S can also inhibit NO production. [27][28][29] There has been no report of androgens increasing NO production or iNOS expression.…”