Dehydroepiandrosterone (DHEA) and aging

The Relationship Between Longitudinal Declines in Dehydroepiandrosterone Sulfate Concentrations and Cognitive Performance in Older Men

“…[24][25][26] Both DHEA-S concentration and cognitive performance showed significant age-related differences in cross-sectional analyses. Moreover, our longitudinal findings confirmed that the age-related decline in DHEA-S concentration was detectable within individuals, replicating the longitudinal studies of Orentreich et al 22 and Nafziger et al 23 Although we cannot confirm the null hypothesis, the fact that our results reproduced well-established findings on age-associated changes suggests that both the DHEA-S concentrations and cognitive measures in the present study were reliable and valid indices of physiological and neurocognitive aging.…”

Effects of In Ovo Administration of DHEA on Lipid Metabolism and Hepatic Lipogenetic Genes Expression in Broiler Chickens During Embryonic Development

“…DHEA is not a hormone but it is a very important prohormone [24], which exerts various physiological activities through intermediate products when administered to rats and mice. The studies from others have revealed that DHEA has various functions on the regulating of lipid metabolism, which includes decreasing the metabolic efficiency in mammalian species [25,26], regulating the synthesis of fat, decreasing the number of adipocytes [27][28][29]. In rodents, long term DHEA treatment resulted in suppression of body weight gain without changes in food intake.…”

The effect of dehydroepiandrosterone (DHEA) on recognition memory decision processes and discrimination in postmenopausal women

“…cerebrospinal fluid, liver, kidney, and brain indicate that it is a biologically active and functionally important hormone (Barrou, Charru, & Lidy, 1997). Second, aging has large effects on DHEA levels.…”