1997
DOI: 10.1016/s0167-4943(96)00761-3
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Dehydroepiandrosterone (DHEA) and aging

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Cited by 43 publications
(20 citation statements)
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“…[24][25][26] Both DHEA-S concentration and cognitive performance showed significant age-related differences in cross-sectional analyses. Moreover, our longitudinal findings confirmed that the age-related decline in DHEA-S concentration was detectable within individuals, replicating the longitudinal studies of Orentreich et al 22 and Nafziger et al 23 Although we cannot confirm the null hypothesis, the fact that our results reproduced well-established findings on age-associated changes suggests that both the DHEA-S concentrations and cognitive measures in the present study were reliable and valid indices of physiological and neurocognitive aging.…”
Section: Commentmentioning
confidence: 93%
“…[24][25][26] Both DHEA-S concentration and cognitive performance showed significant age-related differences in cross-sectional analyses. Moreover, our longitudinal findings confirmed that the age-related decline in DHEA-S concentration was detectable within individuals, replicating the longitudinal studies of Orentreich et al 22 and Nafziger et al 23 Although we cannot confirm the null hypothesis, the fact that our results reproduced well-established findings on age-associated changes suggests that both the DHEA-S concentrations and cognitive measures in the present study were reliable and valid indices of physiological and neurocognitive aging.…”
Section: Commentmentioning
confidence: 93%
“…DHEA is not a hormone but it is a very important prohormone [24], which exerts various physiological activities through intermediate products when administered to rats and mice. The studies from others have revealed that DHEA has various functions on the regulating of lipid metabolism, which includes decreasing the metabolic efficiency in mammalian species [25,26], regulating the synthesis of fat, decreasing the number of adipocytes [27][28][29]. In rodents, long term DHEA treatment resulted in suppression of body weight gain without changes in food intake.…”
Section: Introductionmentioning
confidence: 99%
“…cerebrospinal fluid, liver, kidney, and brain indicate that it is a biologically active and functionally important hormone (Barrou, Charru, & Lidy, 1997). Second, aging has large effects on DHEA levels.…”
mentioning
confidence: 99%