Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders 2008
DOI: 10.1007/978-1-4020-6854-6_14
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Dehydroepiandrosterone and Pregnenolone Alterations in Schizophrenia

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Cited by 7 publications
(8 citation statements)
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“…PREG and its metabolites such as pregnenolone sulfate (PREGS) (both PREG and PREGS [PREG(S)]), DHEA and DHEA sulfate (DHEAS) (both DHEA and DHEAS [DHEA(S)]) are neurosteroids. Figure 1 presents biosynthesis of PREG(S), DHEA(S), and other steroids [6]. Briefly, trophic hormones activate a chain of reactions that lead to the hydrolysis of cholesterol esters into free cholesterol, and the transport of cholesterol into mitochondria where it is converted to PREG by cytochrome P450 side‐chain cleavage (P450 scc; now referred to as CYP11A1).…”
Section: Steroidogenesismentioning
confidence: 99%
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“…PREG and its metabolites such as pregnenolone sulfate (PREGS) (both PREG and PREGS [PREG(S)]), DHEA and DHEA sulfate (DHEAS) (both DHEA and DHEAS [DHEA(S)]) are neurosteroids. Figure 1 presents biosynthesis of PREG(S), DHEA(S), and other steroids [6]. Briefly, trophic hormones activate a chain of reactions that lead to the hydrolysis of cholesterol esters into free cholesterol, and the transport of cholesterol into mitochondria where it is converted to PREG by cytochrome P450 side‐chain cleavage (P450 scc; now referred to as CYP11A1).…”
Section: Steroidogenesismentioning
confidence: 99%
“…DHEA(S) concentrations in the human brain were found to be much higher than in peripheral circulation and also exceeded their very low cerebrospinal fluid (CSF) levels, ranging from about 1% to 5% of the corresponding plasma concentrations. DHEA(S) levels decrease markedly with age in humans, and levels in elderly populations are reduced to 20 to 30% of peak levels in young adulthood (reviewed in [6]).…”
Section: Steroidogenesismentioning
confidence: 99%
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“…In addition to the possible therapeutic effects of sex hormones in schizophrenia, precursors of these sex hormones, such as dehydroepiandrosterone (DHEA; a precursor for both testosterone and estrogen) and pregnenolone, may have neuroprotective properties as well and could therefore play a modifying role in the pathophysiology of schizophrenia (Ritsner et al, 2008;Ritsner, 2010). These precursors have many functions of their own, including mood regulation, cognitive performance, and response to stress (Mellon, 2007;Maninger et al, 2009).…”
Section: Introductionmentioning
confidence: 98%
“…5 There is evidence that PREG and its metabolites may be involved in the pathophysiology of schizophrenia, mood disorders, dementia and substance abuse. [6][7][8] Clinical studies demonstrated low circulating levels of PREG in the elderly, including those with dementia, 6 in individuals with major depression, 7 anxiety disorder, 9 and in chronic medicated schizophrenia patients. 10 Two clinical trials with add-on PREG in chronic SZ/SA were published.…”
mentioning
confidence: 99%