Dehydration followed by sham rehydration contributes to reduced neuronal activation in vasopressinergic supraoptic neurons after water deprivation

Knight, W. David; Ji, Lianghui; Little, Joel T.; Cunningham, J. Thomas

doi:10.1152/ajpregu.00066.2010

Cited by 9 publications

(10 citation statements)

References 71 publications

(89 reference statements)

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“…This decrease in Fos in the SON is consistent with a decrease in plasma arginine vasopressin levels observed in our previous work [31]. Sham rehydration in the rats attenuated the decreased Fos in the SON associated with water intake suggesting that pre-absorptive and post-absorptive mechanisms contribute to this effect [25]. …”

Section: Discussionsupporting

confidence: 89%

“…The inhibitory effects of baroreceptors on the SON would involve a pathway from the NTS that could include the perinuclear zone of the SON (PNZ) and the diagonal band of Broca [43]. Information from osmo-sensitive superior laryngeal afferents also would influence the SON through the NTS and possibly the PNZ as well [25]. The NTS projects directly to the PNZ [44] but also has an extensive afferent network that includes the parabrachial nucleus and the lamina terminalis [45].…”

Section: Discussionmentioning

confidence: 99%

“…Colocalization was determined by capturing separate images using an IX50 Olympus converted to a DSU confocal microscope with an attached mercury lamp for fluorescence. The bright field Fos image was inverted and adjusted to remove background artifacts, pseudocolored green, and merged with the dark field oxytocin image to observe colocalization as previously described [25]. Artifacts placed in each brain ipsilateral to the SLNX section were used to determine whether the region was from the intact or denervated side.…”

Section: Methodsmentioning

confidence: 99%

“…Other investigators have shown that the application of hypertonic or hypotonic solutions into the oral cavity of anesthetized rats will increase or decrease the activity of putative magnocellular neurosecretory cells [23, 24]. We have recently observed that sham rehydration with water significantly attenuates the reduction in Fos staining in the SON that is produced when dehydrated rats drink water [25]. This suggests that pre-absorptive signals from the gastrointestinal tract or the oral cavity related to water intake do influence the activity of neurons in the SON in the rat.…”

Section: Introductionmentioning

confidence: 99%

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Role of superior laryngeal nerve and Fos staining following dehydration and rehydration in the rat

Gottlieb

Cunningham

2011

Physiology & Behavior

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Immunohistochemistry for Fos was used to determine the role of the superior laryngeal nerve in conscious rats following water deprivation and rehydration. Adult male rats were subjected to either unilateral superior laryngeal nerve section (SLNX) or sham surgery. Two weeks later rats from each surgical group were water deprived for 48 h or water deprived for 46 h hours and given access to water for 2 h prior to perfusion. Controls were allowed ad libitum access to water. Brains were processed for Fos using a commercially available antibody. Changes in plasma osmolality and hematocrit were not significantly different between SLNX and sham following any of the treatments. Water intake in rats was not significantly affected by SLNX. In the supraoptic nucleus (SON) of sham rats, water deprivation significantly increased Fos staining while water intake following dehydration prevented this increase. Water deprivation significantly increased Fos staining in the SON of SLNX rats. Following water intake after 46 h water deprivation in SLNX rats, Fos staining in the ipsilateral SON was significantly greater than the contralateral SON and significantly lower than 48 h water deprivation. In the nucleus of the solitary tract (NTS) of sham rats, both water deprivation and water intake produced significant increases in Fos staining bilaterally compared to euhydrated controls. In SLNX rats, water deprivation significantly increased Fos in both ipsilateral and contralateral NTS that was not different from sham rats. SLNX significantly decreased Fos staining in the ipsilateral NTS of rats given access to water after dehydration compared to the corresponding sham treated rats. Fos staining was not affected in the contralateral NTS of SLNX rats given access to water after dehydration. This suggests that the superior laryngeal nerve contributes to changes in Fos staining in the NTS and SON following water intake in dehydrated rats.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of superior laryngeal nerve and Fos staining following dehydration and rehydration in the rat

Gottlieb

Cunningham

2011

Physiology & Behavior

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“…Water deprivation influences a whole plethora of physiological functions such as increase of corticoid secretion (Mornagui et al 2010) and arginine-vasopressin levels (Knight et al 2010), osmolality dysregulation (Stricker et al 2002), increase of plasma renin activity (Nagai et al 1993) and sodium concentration (De Luca et al 2010), decrease of urinary volume (Jorgensen et al 1993), and alterations in brain expression of angiotensinconverting enzyme (Bourassa and Speth 2010). However, we show that the induction of state-dependent memories may be supported, e.g., by the renin -angiotensin system (RAS), since the water deprivation effects were replicated by the infusion of ANGII into the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Reconsolidation may incorporate state-dependency into previously consolidated memories

et al. 2013

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Some memories enter into a labile state after retrieval, requiring reconsolidation in order to persist. One functional role of memory reconsolidation is the updating of existing memories. There are reports suggesting that reconsolidation can be modulated by a particular endogenous process taking place concomitantly to its natural course, such as water or sleep deprivation. Here, we investigated whether an endogenous process activated during a natural/physiological experience, or a pharmacological intervention, can also contribute to memory content updating. Using the contextual fear conditioning paradigm in rats, we found that the endogenous content of an aversive memory can be updated during its reconsolidation incorporating consequences of natural events such as water deprivation, transforming a previously stored memory into a state-dependent one. This updating seems to be mediated by the activation of angiotensin AT1 receptors in the dorsal hippocampus and local infusion of human angiotensin II (ANGII) was shown to mimic the water deprivation effects on memory reconsolidation. Systemic morphine injection was also able to turn a previously acquired experience into a state-dependent memory, reproducing the very same effects obtained by water deprivation or local angiotensin II infusion, and suggesting that other state-dependent-inducing protocols would also be able to contribute to memory updating. These findings trigger new insights about the influence of ordinary daily life events upon memory in its continuing reconstruction, adding the realm of reconsolidation to the classical view of endogenous modulation of consolidation.

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Hypothalamic Supraoptic and Paraventricular Nuclei

Armstrong

2015

The Rat Nervous System

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Dehydration followed by sham rehydration contributes to reduced neuronal activation in vasopressinergic supraoptic neurons after water deprivation

Cited by 9 publications

References 71 publications

Role of superior laryngeal nerve and Fos staining following dehydration and rehydration in the rat

Role of superior laryngeal nerve and Fos staining following dehydration and rehydration in the rat

Reconsolidation may incorporate state-dependency into previously consolidated memories

Hypothalamic Supraoptic and Paraventricular Nuclei

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