Degree of methylation of<i>ZAC1</i>(<i>PLAGL1</i>) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort

Azzi, Salah; Sas, Theo C J; Koudou, Yves Akoli; Bouc, Yves Le; Souberbielle, Jean‐Claude; Dargent-Molina, Patricia; Netchine, Irène; Munier, Charles

doi:10.4161/epi.27387

Cited by 71 publications

(50 citation statements)

References 45 publications

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“…Studies also pointed to the prenatal period as a particularly sensitive developmental window. For example, in utero substance exposure influenced DNAm of developmental genes, which in turn affected postnatal outcomes (e.g., reduced postnatal weight [37]), although the relevance of these changes for addiction risk is yet to be characterised. It is important to note that the period between birth and adulthood received very little attention.…”

Section: Summary Of Study Characteristics and Findingsmentioning

confidence: 99%

“…Wilhelm-Benartzi et al [36] found that maternal alcohol intake positively associated with global LINE-1 (but not with AluYb8) methylation in placental tissue. One candidate gene study found that cord blood methylation of the developmental gene ZAC1 positively correlated with prenatal maternal alcohol intake as well as associating with reduced fetal and postnatal weight [37]. …”

Section: Prenatalmentioning

confidence: 99%

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DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

2015

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Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction. We conducted a systematic review of 47 recent (2012)(2013)(2014)(2015) animal and human studies that investigate DNA methylation and substance use/exposure, spanning preconception to adulthood. The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional. While studies generally support an association between substance use/exposure and DNA methylation and also suggest that developmental context and timing matter, a dearth of longitudinal data and low comparability across studies currently limits the conclusions that can be drawn. Future challenges and directions for the field are discussed.

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Section: Summary Of Study Characteristics and Findingsmentioning

confidence: 99%

Section: Prenatalmentioning

confidence: 99%

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

2015

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“…For example, newborn of obese parents show altered DNA methylation profiles of multiple imprinted genes, which may be carried onto the next generation and confer an increased risk for metabolic diseases in adulthood [116] . Moreover, the degree of methylation of ZAC1 associates with pre-and postnatal growth in healthy infants as well as with maternal nutrition and lasts at least until the first year of life [117] . Similarly, individuals prenatally exposed to famine showed 6 decades later less DNA methylation of IGF2 compared with their unexposed, same-sex siblings [118] , although variation in DNA methylation at this locus is thought to increase as a result of the aging process itself [119] .…”

Section: Resultsmentioning

confidence: 99%

ImprintedZac1in neural stem cells

Daniel

Schmidt-Edelkraut

Spengler

et al. 2015

WJSC

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Neural stem cells (NSCs) and imprinted genes play an important role in brain development. On historical grounds, these two determinants have been largely studied independently of each other. Recent evidence suggests, however, that NSCs can reset select genomic imprints to prevent precocious depletion of the stem cell reservoir. Moreover, imprinted genes like the transcriptional regulator Zac1 can fine tune neuronal vs astroglial differentiation of NSCs. Zac1 binds in a sequence-specific manner to pro-neuronal and imprinted genes to confer transcriptional regulation and furthermore coregulates members of the p53-family in NSCs. At the genome scale, Zac1 is a central hub of an imprinted gene network comprising genes with an important role for NSC quiescence, proliferation and differentiation. Overall, transcriptional, epigenomic, and genomic mechanisms seem to coordinate the functional relationships of NSCs and imprinted genes from development to maturation, and possibly aging.

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“…Salah Azzi и соавт. [2] полагают, что метилирование DMR гена PLAGL1 способствует установлению контроля над скоро-стью прироста массы тела плода и ребенка. Не ис-ключено, что протеин PLAGL1 участвует в регуля-ции секреции инсулина в постнатальном периоде жизни.…”

Section: âèòàìèí Bunclassified

Вплив Екзогенних Факторів На Геномний Імпринтинг . 1. Вплив Дієти І Забезпеченості Мікронутрієнтами Матері На Геномний Імпринтинг Нащадків

Абатуров

Moroz

2021

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Degree of methylation ofZAC1(PLAGL1) is associated with prenatal and post-natal growth in healthy infants of the EDEN mother child cohort

Cited by 71 publications

References 45 publications

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

ImprintedZac1in neural stem cells

Вплив Екзогенних Факторів На Геномний Імпринтинг . 1. Вплив Дієти І Забезпеченості Мікронутрієнтами Матері На Геномний Імпринтинг Нащадків

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