Degradation rates of polymers and copolymers of polylactic and polyglycolic acids

Cutright, Duane E.; Perez, Bienvenido; Beasley, J. N.; Larson, Wayne J.; Posey, William R.

doi:10.1016/0030-4220(74)90171-6

Cited by 199 publications

(57 citation statements)

References 4 publications

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“…Scaffold degradation is dependent on bone turnover and could be influenced by other factors, such as the access to vasculature, the mechanical loading, and the metabolism of degradation products [34]. Pure PLA scaffolds were shown to be degradable in rats [19] and in rabbits [35]. One advantage of combining ceramic and polymer is to control resorption rates [36].…”

Section: Discussionmentioning

confidence: 99%

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Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Montjovent

Mark

Mathieu

et al. 2008

Bone

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Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promote bone repair in vivo when combined with porous scaffolds based on poly(L-lactic acid) (PLA) obtained by supercritical gas foaming and reinforced with 5 wt.% β-tricalcium phosphate (TCP).Bone regeneration was assessed by radiography and histology after implantation of PLA/TCP scaffolds alone, seeded with primary fetal bone cells, or coated with demineralized bone matrix. Craniotomy critical size defects and drill defects in the femoral condyle in rats were employed. In the cranial defects, polymer degradation and cortical bone regeneration were studied up to 12 months postoperatively. Complete bone ingrowth was observed after implantation of PLA/TCP constructs seeded with human fetal bone cells. Further tests were conducted in the trabecular neighborhood of femoral condyles, where scaffolds seeded with fetal bone cells also promoted bone repair.We present here a promising approach for bone tissue engineering using human primary fetal bone cells in combination with porous PLA/TCP structures. Fetal bone cells could be selected regarding osteogenic and immune-related properties, along with their rapid growth, ease of cell banking and associated safety.

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Section: Discussionmentioning

confidence: 99%

“…Several animal models are described to test implants in cancellous bone [19][20][21] and the femoral condyle is often used for this purpose [22,23]. Due to its vascularization and the presence of precursor cells, this location is of particular interest to assess in parallel biodegradation and bone repair processes [24].…”

Section: Introductionmentioning

confidence: 99%

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Montjovent

Mark

Mathieu

et al. 2008

Bone

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“…They are biodegradable to nontoxic compounds and have been demonstrated to incorporate readily lipid soluble drugs [11][12]. The rate of drug release can be varied by altering the size and drug content of the microspheres and degree of polymer cross linking [13][14].…”

Section: Introductionmentioning

confidence: 99%

Sustained local drug delivery to the arterial wall via biodegradable microspheres

Dev¹,

Eigler²,

Fishbein

et al. 1997

Cathet. Cardiovasc. Diagn.

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“…(3) The polylactic acid derived from DL-lactic acid is less ordcrcd than that from L ( + ) lactic acid, so the former, when used, will degrade faster than the latter [21]. The release profile should have an initial high release rate to accommodate the possibility of infection just after an operation, followed by 4-6 weeks of a constant release above the breakpoint sensitivity level [9,11,25,27,341. In most previous studies, thc antibiotic was microencapsulated in a poly ( D L -1actide-co-glycolide) bead with a high molecular weight (molecular weight 3.26 x lo4 Da), a high percentage of the poly(1actic acid) ratio (70:30), a high antibiotic loading dosage (50%) and a high formation temperature ( 1 10 "C).…”

Section: Discussionmentioning

confidence: 99%

In vivo study of hot compressing molded 50:50 poly (DL‐lactide‐co‐glycolide) antibiotic beads in rabbits

Ueng¹,

Yuan²,

Liao³

et al. 2002

Journal Orthopaedic Research

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The authors investigated poly (DL-lactide-co-glycolide) beads as an antibiotic delivery system in vivo for the treatment of various surgical infections. In this study, the copolymer 50:50 poly (DL-lactide):co-glycolide was mixed with vancomycin powder and hot compressing molded at 55 "C to form 8 mm in diameter biodegradable antibiotic beads. The antibiotic beads were implanted in the distal femoral cavities of rabbits for in vivo investigation. The local concentration of vancomycin was well above the breakpoint sensitivity concentration (the antibiotic concentration at the transition point between bacterial killing and resistance to the antibiotic) for 56 days. The release was most marked during the first day. The diameters of the sample inhibition zone ranged from 8 to 18 mm, and the relative activity of vancomycin ranged from 9.1'%1 to 100'%l. Only low systemic blood levels of vancomycin were measured after beads implantation. There was no increase in the concentration of blood urea nitrogen and serum creatinine after the implantation. Histological observations showed that the bead materials were biodegradable, resorbed slowly, and did not cause a significant host reaction. This study offers a biodegradable delivery system of antibiotics to treat various surgical infections.

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Degradation rates of polymers and copolymers of polylactic and polyglycolic acids

Cited by 199 publications

References 4 publications

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Sustained local drug delivery to the arterial wall via biodegradable microspheres

In vivo study of hot compressing molded 50:50 poly (DL‐lactide‐co‐glycolide) antibiotic beads in rabbits

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