Degradation of thiamethoxam and metoprolol by UV, O3 and UV/O3 hybrid processes: Kinetics, degradation intermediates and toxicity

Šojić, Daniela V.; Despotović, Vesna; Orčić, Dejan; Szabó, Emese; Arany, Eszter; Armaković, Sanja J.; Illés, Erzsébet; Gajda‐Schrantz, Krisztina; Dombi, András; Alapi, Tünde; Sajben-Nagy, Enikő; Palágyi, Andrea; Vágvölgyi, Csaba; László, Manczinger; Bjelica, Luka J.; Abramović, Biljana F.

doi:10.1016/j.jhydrol.2012.09.038

Cited by 104 publications

(32 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The advanced oxidation processes (AOPs) have been highlighted, with satisfactory results in the removal of several organic compounds including pharmaceuticals [10,[18][19][20][21][22][23]. Studies have reported the removal of MET by different AOPs, including ozonation [12], UV/H 2 O 2 [24], photo-Fenton [25][26][27], photocatalysis [12,14,[28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

et al. 2015

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

et al. 2015

View full text Add to dashboard Cite

“…Metoprolol was positive for genetic damage in algae Pseudokirchneriella subcapitala and in the bacteria Vibrio fischeri. 39) Genetic damage was also observed in Chinese hamster lung cells treated with aspirin. 35,36) Ramipril induced agranulocytosis in chronic renal failure patients, confirmed by a lymphocyte cytotoxicity test.…”

Section: Discussionmentioning

confidence: 94%

“…In the literature, earlier studies have also supported the relation between DNA damage and severity of CAD. 6,15,11) Prescribed medications, despite having antioxidant properties, [32][33][34] also have been reported to have genotoxic potential [35][36][37][38][39] implying that treatment with these medications can induce genetic damage. The medications prescribed for the management of CAD in the present study included metoprolol (beta-blocker), aspirin, ecosprin (antiplatelet therapy), ramipril (ACE-inhibitor), and nitrocontin (nitrates).…”

Section: Discussionmentioning

confidence: 99%

“…38) Andreassi, et al 14,37) have documented significantly higher micronucleus frequency in the lymphocytes of ischemic and CAD patients on treatment with nitrates. On the basis of the genotoxic nature of aspirin, 35,36) ramipril, 38) metoprolol 39) and nitrocontin, 14,37) the patients taking these drugs could also be susceptible to DNA damage from these drugs. Therefore, the genotoxic nature of these drugs cannot be ignored, like the carcinogenicity of cardiovascular drugs, including diuretics, beta blockers, calcium antagonists, and ACE-inhibitors has also been debated.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of DNA Damage in Leukocytes of Patients With Coronary Artery Disease by Comet Assay

Bhat

Gandhi

2017

Int. Heart J.

View full text Add to dashboard Cite

SummaryDNA damage in the peripheral blood leukocytes (PBL) of patients with coronary artery disease (CAD) was investigated using the sensitive alkaline single cell gel electrophoresis (SCGE)/comet assay.This case-control study consisted of CAD patients (n = 200; mean age, 59.04 ± 0.75 years) undergoing treatment at local hospitals and age-, sex-, and ethnicity-matched healthy controls (n = 200; mean age, 57.88 ± 0.96 years) from the general population.CAD patients had significantly (P < 0.001) increased DNA damage (tail DNA percent (T-DNA %) 22.45 ± 0.50 versus 5.81 ± 0.28; tail moment (TM) 89.35 ± 3.16 versus 9.98 ± 0.69; Olive tail moment (OTM) 60.50 ± 1.79 versus 10.94 ± 0.63; damage frequency (DF) 91.12 ± 0.93 versus 41.78 ± 2.04, damage index (DI) 173.68 ± 3.36 versus 48.53 ± 2.59) compared to controls. Patients with acute myocardial infarction (AMI) showed significantly higher DNA damage than patients with unstable angina (UA) (T-DNA % 24.05 ± 0.87 versus 21.06 ± 0.90; TM 100.02 ± 6.19 versus 81.61 ± 5.84; OTM 66.19 ± 3.20 versus 56.47 ± 3.33; DF 94.02 ± 0.84 versus 91.10 ± 1.16, DI 184.13 ± 5.33 versus 166.42 ± 5.89). Moreover, DNA damage was found to be significantly (P < 0.05) elevated in patients receiving ecosprin, ramipril, and metoprolol therapy compared to aspirin and nitrocontin.The increased DNA damage in CAD patients may be the consequence of disease and/or drug therapy. These observations are of concern because unrepaired DNA can lead to malignancy, and the likelihood of increasing mortality and morbidity rates in CAD patients. (Int Heart J 2017; 58: 271-274)

show abstract

“…Az utóbbi vízzel reagálva hidroxilgyököt képez (5) (Prengle, 1983;Benoit-Guyod és mtsai., 1986). Olyan feltételezés is létezik, mely szerint a hidroxilgyök H 2 O 2 -on keresztül jön létre (6,7).…”

Section: Gyógyszerek éS Metabolitjaik Előfordulása a Szennyvizekben éunclassified

Radiolízis és egyéb nagyhatékonyságú oxidációs eljárások alkalmazása nem-szteroid gyulladáscsökkentők bontására vizes oldatokban

Illés

View full text Add to dashboard Cite

Degradation of thiamethoxam and metoprolol by UV, O3 and UV/O3 hybrid processes: Kinetics, degradation intermediates and toxicity

Cited by 104 publications

References 50 publications

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

Synthesis and characterization of B-doped TiO2 and their performance for the degradation of metoprolol

Assessment of DNA Damage in Leukocytes of Patients With Coronary Artery Disease by Comet Assay

Radiolízis és egyéb nagyhatékonyságú oxidációs eljárások alkalmazása nem-szteroid gyulladáscsökkentők bontására vizes oldatokban

Contact Info

Product

Resources

About