Degradation of poly(d,l)lactide implants with or without addition of calciumphosphates in vivo

Heidemann, W.; Jeschkeit, S.; Ruffieux, Kurt; Fischer, J.; Wagner, Mathias; Krüger, Gerhard; Wintermantel, E.; Gerlach, Klaus

doi:10.1016/s0142-9612(00)00424-5

Cited by 153 publications

(111 citation statements)

References 35 publications

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“…The further development of PDLLA/bioglass® composite materials is interesting also due to the fact that PDLLA degrades without generation of any crystalline remnants. Heideman et al, have proved very recently, for example, the complete resorption of PDLLA implants from the extracellular space in animal studies, therefore confirming their tissue tolerance [35]. The course of degradation is more questionable for slowly degradable, crystalline PDLLA of high molecular weight.…”

Section: In Vitro Studies In Sbfmentioning

confidence: 91%

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

et al. 2002

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Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering.

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Section: In Vitro Studies In Sbfmentioning

confidence: 91%

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

et al. 2002

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“…This indicates that the osteoconductive effect of the biomaterial, similar to the examined ones, is necessary for higher levels of osteogenesis and complete healing. In the subgroup where HAp-PLLA composite was implanted, 24 weeks after implantation, besides intensive formation of a new bone, increased binding, as well as migration and distribution of vascular and osteogenic cells within remnants of implanted material were noticed, which confirmed the osteoconductive effect of that biocomposite [9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 85%

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

et al. 2005

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The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.

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“…The problem was succesfully solved by the application of basic calcium phosphates or carbonated calcium phosphates, which neutralised acid biopolymer degradation products [1,2,3,4]. PHB-calcium phosphate composites have been generally prepared by the solvent method, wet or hot compression and injection moulding [5][6][7][8]. Ni et al [9] studied the effect of hydroxyapatite (HA) content on mechanical properties and bioactivity in PHB-HA composites.…”

Section: Introductionmentioning

confidence: 99%

Properties of Powder Composite Polyhydroxybutyrate–Chitosan-Calcium Phosphate System

Medvecký

Štulajterová

Giretová

et al. 2017

Powder Metallurgy Progress

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Degradation of poly(d,l)lactide implants with or without addition of calciumphosphates in vivo

Cited by 153 publications

References 35 publications

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass® for tissue engineering applications

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

Properties of Powder Composite Polyhydroxybutyrate–Chitosan-Calcium Phosphate System

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