Degradation of Crystalline Ergocalciferol [Vitamin D2, (3β, 5Z, 22E)- 9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol]

Development of an Improved Process for Doxercalciferol via a Continuous Photochemical Reaction

“…The photoisomerization apparatus was wrapped in aluminum foil to contain the light and was further placed into a safety cabinet. A helium-sparged heptane solution of 15 and a photosensitizer, 9-acetylanthracene (9-AA), was continuously passed via a metering pump through the apparatus into a collection chamber. Both anthracene and 9-AA have been previously reported as required and effective triplet photosensitizers in the photoisomerization of related vitamin D triene systems. , Starting material and collection flasks were wrapped in foil to avoid fortuitous exposure to light.…”

Lipophilic Vitamins

“…Stewart et al (64) investigated the products of the degradation of crystalline ergocalciferol. Stewart et al (64) investigated the products of the degradation of crystalline ergocalciferol.…”