Degradation of calcium phosphate ceramics

Koerten, Henk K.; Meulen, J van der

doi:10.1002/(sici)1097-4636(199901)44:1<78::aid-jbm9>3.0.co;2-6

Cited by 139 publications

(103 citation statements)

References 15 publications

(15 reference statements)

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“…Recent "ndings that osteoblasts phagocytosed Ti particles [29] and osteoblasts treated with cytochalasin-D (agent that inhibits phagocytosis by affecting actin "lament assembly of the cytoskeleton) almost completely suppressed the negative e!ect of Ti particle on osteoblast viability [17] supports this hypothesis. As for the macrophages or multinucleated giant cells [19], this phagocytosis process could produce an accumulation of calcium in mitochondria and could eventually lead to lysis of mitochondria and cell death. Impact of CPC particles on osteoblast functions could Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have been performed with CPC particles smaller than 10 m. An in vivo study using mice has shown that CPC particles of around 10 m could be degraded by macrophages or multinucleated giant cells [19]. This degradation process produced an accumulation of calcium in mitochondria and "nally led to lysis of mitochondria and cell death [19].…”

Section: Introductionmentioning

confidence: 99%

“…This degradation process produced an accumulation of calcium in mitochondria and "nally led to lysis of mitochondria and cell death [19]. Very little information is actually available on reaction of osteoblasts to CPC particles.…”

Section: Introductionmentioning

confidence: 99%

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The effects of calcium phosphate cement particles on osteoblast functions

et al. 2000

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Calcium phosphate cements (CPC) are increasingly used in the orthopedic "eld. This kind of cement has potential applications in bone defect replacements, osteosynthetic screw reinforcements or drug delivery. In vivo studies have demonstrated a good osteointegration of CPC. However, it was also observed that the resorption of CPC could create particles. It is known from orthopedic implant studies that particles can be responsible for the peri-implant osteolysis. Biocompatibility assessment of CPC should then be performed with particles. In this study, we quanti"ed the functions of osteoblasts in the presence of -TCP, brushite and cement particles. Two particle sizes were prepared. The "rst one corresponded to the critical diameter range 1}10 m and the second one had a diameter larger than 10 m. We found that CPC particles could adversely a!ect the osteoblast functions. A decrease in viability, proliferation and production of extracellular matrix was measured. A dose e!ect was also observed. A ratio of 50 CPC particles per osteoblast could be considered as the maximum number of particles supported by an osteoblast. The smaller particles had stronger negative e!ects on osteoblast functions than the larger ones. Future CPC development should minimize the generation of particles smaller than 10 m.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of calcium phosphate cement particles on osteoblast functions

et al. 2000

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“…Also, dissolution-precipitation reactions that are involved during calcium phosphate resorption (LeGeros, 1993;Koerten and van der Meulen, 1999;LeGeros, 2002;Le Nihouannen et al, 2005) were seen to occur between partly dissolved grains ( Van der Meulen and Koerten, 1994). LeGeros et al (LeGeros et al, 1988) and Klein et al (Klein et al, 1983;Klein et al, 1986) observed an increase in resorption rate with a decrease in grain size.…”

Section: No Differencementioning

confidence: 99%

Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds

Lapczyna

Galea²,

Wüst

et al. 2014

eCM

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Defining the most adequate architecture of a bone substitute scaffold is a topic that has received much attention over the last 40 years. However, contradictory results exist on the effect of grain size and microporosity. Therefore, the aim of this study was to determine the effect of these two factors on the in vivo behaviour of β-tricalcium phosphate (β-TCP) scaffolds. For that purpose, β-TCP scaffolds were produced with roughly the same macropore size (≈ 150 μm), and porosity (≈ 80 %), but two levels of microporosity (low: 10 % / high: ≈ 25 %) and grain size (small: 1.3 μm /large: ≈ 3.3 μm). The sample architecture was characterised extensively using materialography, Hg porosimetry, micro-computed tomography (μCT), and nitrogen adsorption. The scaffolds were implanted for 2, 4 and 8 weeks in a cylindrical 5-wall cancellous bone defect in sheep. The histological, histomorphometrical and μCT analysis of the samples revealed that all four scaffold types were almost completely resorbed within 8 weeks and replaced by new bone. Despite the three-fold difference in microporosity and grain size, very few biological differences were observed. The only significant effect at p < 0.01 was a slightly faster resorption rate and soft tissue formation between 4 and 8 weeks of implantation when microporosity was increased. Past and present results suggest that the biological response of this particular defect is not very sensitive towards physico-chemical differences of resorbable bone graft substitutes. As bone formed not only in the macropores but also in the micropores, a closer study at the microscopic and localised effects is necessary.

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“…the sealing zone) that delimits the resorbing area onto which osteoclasts generate an acid milieu that can reach values below pH 3, resulting in the dissolution of the underlying mineral [36]. In this regards, studies performed at low pH can be used as predictors of osteoclastic degradation [37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Degradation of calcium phosphate ceramics

Cited by 139 publications

References 15 publications

The effects of calcium phosphate cement particles on osteoblast functions

The effects of calcium phosphate cement particles on osteoblast functions

Effect of grain size and microporosity on the in vivo behaviour of β-tricalcium phosphate scaffolds

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

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