Degradation dynamics, residues and risk assessment of Dufulin enantiomers in corn plants and corn by LC/MS/MS

Shi, Li; Zhao, S. J.; Gui, Ting; Wang, Fei; Zhang, Yu P; Hu, De Y

doi:10.1080/03601234.2018.1480165

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…Conversely, the degradation rate of R ‐(–)‐dufulin is faster than that of S ‐(+)‐dufulin in watermelon (Zheng et al 2017). However, S ‐(+)‐dufulin and R ‐(–)‐dufulin have the same degradation half‐lives in corn, and no enantioselectivity is observed (Shi et al 2018). This result may be attributed to the differences in environmental media and species, thereby causing the dufulin enantiomers to show different degradation trends.…”

Section: Resultsmentioning

confidence: 99%

“…Their data indicate that when rac ‐dufulin is applied to watermelon, the dissipation rate of the R enantiomer is faster than that of the S enantiomer. Shi et al (2018) investigated the enantioselective degradation of dufulin in corn, with no enantioselectivity observed in corn. However, few studies have described the environmental behavior of dufulin at enantiomeric or racemic levels in aquatic animals.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

Jiang

Song

Wang

et al. 2020

Enviro Toxic and Chemistry

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Dufulin is a new type of chiral antiplant virus agent independently developed in China. The present study was conducted to determine the effects of different concentrations of rac-dufulin and dufulin enantiomers (1, 5, and 10 mg/L) on oxidative stress in Tubifex after exposure for 3, 7, and 14 d. Results showed that rac-dufulin and individual enantiomers had no significant effects on total protein content and glutathione reductase activities. Increased superoxide dismutase demonstrated the generation of superoxide anion radical. The increase in glutathione S-transferase may be due to detoxification mechanisms. The different changes in catalase activities could be due to oxidative stress. The increase in malondialdehyde may be due to the accumulation and toxicity of contaminations. The degradation behavior of dufulin enantiomers was studied through spiked-water and spiked-soil tests. The degradation rate of S-(+)-dufulin was faster than that of R-(−)-dufulin. The present study demonstrated the occurrence of enantioselectivity in the degradation and oxidative stress of dufulin to Tubifex. In spiked soil, the concentrations of dufulin enantiomers in underlying soil were significantly higher than those in overlying water; but after 5 d of degradation, the bioturbation of Tubifex could facilitate part of dufulin diffusing from the underlying soil into the overlying water and altered the partitioning of dufulin. The present study provided a basis for conducting environmental safety risk assessments and rationally using dufulin as a chiral pesticide.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

Jiang

Song

Wang

et al. 2020

Enviro Toxic and Chemistry

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“…Dietary exposure calculation and risk assessment were evaluated based on the hazard index (HI) method (Shi et al, ; Tsoutsi, Konstantinou, & Hela, ).

IEDI = STMR \times F \times italicPi / normalb . normalw .

{HI}_{C} = \frac{IEDI}{ADI}

…”

Section: Methodsmentioning

confidence: 99%

Monitoring residue levels and dietary risk assessment of pymetrozine for Chinese consumption of cauliflower

Jia

Zeng

Zhao

et al. 2018

Biomedical Chromatography

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The present study investigates the occurrence of pymetrozine residues in cauliflower samples obtained from six cauliflower‐producing areas of China during fixed time periods in 2017 and estimates the dietary risk of pymetrozine in cauliflower. A liquid chromatography with tandem mass spectrometry method was developed and validated to detect pymetrozine in cauliflower. The samples were extracted using 20 mL of acetonitrile and purified with dispersive solid‐phase extraction using C18 as sorbent. The limit of quantification of pymetrozine was 0.008 mg/kg in cauliflower. The recoveries of the analyte were 82.04–95.18% with RSD <8.45%. The calibration curves for pymetrozine showed good linearities in the concentration range 0.004–2.0 mg/L with determination coefficients (R2) >0.999. Pymetrozine dissipated rapidly in cauliflower with a half‐life of <4 days. The terminal residues of pymetrozine were <0.008–0.0881 mg/kg in cauliflower at 7, 10 and 14 days after spraying from six sites. The routine washing process removed about half amount of the pymetrozine in cauliflower; the reduction ratios were 51.0–52.8%. The dietary risk assessment indicated that pymetrozine did not exhibit obvious dietary health risks in cauliflower when good agricultural practices were implemented.

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“…The study of the residues and dissipation of pesticides in crops is a very effective method for establishing the recommended dose and safety interval. In addition, the research data can also provide scientific support for the formulation of MRLs 8‐10 . However, so far, there has been little attention in China on the residue and digestion of isoxaflutole in corn.…”

Section: Introductionmentioning

confidence: 98%

“…In addition, the research data can also provide scientific support for the formulation of MRLs. [8][9][10] However, so far, there has been little attention in China on the residue and digestion of isoxaflutole in corn.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of isoxaflutole and its two metabolites in corn under field conditions by LC–MS/MS

Lan

Sun

et al. 2021

J Sci Food Agric

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OBJECTIVE An improved QuEChERS method was established and verified for simultaneous determination of isoxaflutole and its metabolites diketonitrile and benzoic acid analogue residues in corn and plants. This method was mainly used to study the digestion rule and final residue level of isoxaflutole and its metabolites in corn and plants. It was hoped that the safe use of isoxaflutole in corn can be achieved eventually. METHOD The method was completed by means of ultra‐performance liquid chromatography with triple quadrupole mass spectrometry. The extraction of the target substance was through acetonitrile solution containing 1% acetic acid, and the purification was through primary secondary amine, octadecylsilane and graphitized carbon black sorbent. RESULTS In the method, the quantitative limits and detection limits of the three analytes were 0.005–0.01 and 0.001–0.003 mg kg−1 respectively. The half‐life of isoxaflutole in the plants in Shandong and Anhui was 36.4 and 42.1 days respectively, and the digestion dynamics all conformed to the first‐order kinetics. The final residues of isoxaflutole in green corn and mature corn were less than 0.02 mg kg−1 of the maximum residue limit set by the Codex Alimentarius Commission. CONCLUSIONS The residual amount of isoxaflutole in corn and plants at harvest time was acceptable when isoxaflutole was applied once at a dose of 121.5 g a.i. ha−1. © 2021 Society of Chemical Industry.

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Degradation dynamics, residues and risk assessment of Dufulin enantiomers in corn plants and corn by LC/MS/MS

Cited by 12 publications

References 23 publications

Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

Oxidative Stress and Enantioselective Degradation of Dufulin on Tubifex

Monitoring residue levels and dietary risk assessment of pymetrozine for Chinese consumption of cauliflower

Simultaneous determination of isoxaflutole and its two metabolites in corn under field conditions by LC–MS/MS

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