Degradation behaviors and in-vivo biocompatibility of a rare earth- and aluminum-free magnesium-based stent

Bian, Dong; Zhou, Xiaochen; Liu, Jianing; Li, Wenting; Shen, Danni; Zheng, Yufeng; Gu, Wenda; Jiang, Jingjun; Li, Mei; Chu, Xiao; Ma, Limin; Wang, Xiaolan; Leeflang, M.A.; Zhou, Jie

doi:10.1016/j.actbio.2021.01.031

Cited by 22 publications

(12 citation statements)

References 69 publications

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“…1 ) [ 37 , 57 , 58 ]. According to application requirements, a large number of Mg alloys with excellent performance that is suitable for vascular stents have been designed, including AE21 alloy [ 59 ], WE43 alloy [ 60 , 61 ], AZ91 alloy [ 62 ], Mg-Nd-Zn-Zr alloy (JDBM) [ 63 , 64 ], and Mg-Zn-Y-Nd alloy (ZE21B) [ 65 , 66 ]. However, the amount of alloy elements required is larger, and the cost is higher.…”

Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

105

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Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

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Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

105

View full text Add to dashboard Cite

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“…Homogeneous vessel walls and intact cross-sectional pictures of stent struts were found at 1 month. Three months after the MgF 2 -PA-PLGA stents were implanted, the lumen was obviously lost, and the intima thickness increased, which may be related to the rapid degradation of the stents [ 65 ]. At six months, a few stent struts were seen.…”

Section: Resultsmentioning

confidence: 99%

“…It has been demonstrated that during stent compression and expansion, stress concentrations are observed at stent bending locations [ 67 ]. Although the degree of stress concentration can still be reduced by optimizing the structure [ 3 , 65 ], it remains inevitable. Therefore, the coating's protection just delays the beginning of corrosion in the stress concentration area [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

A “built-up” composite film with synergistic functionalities on Mg–2Zn–1Mn bioresorbable stents improves corrosion control effects and biocompatibility

Dou

Chen

Wang

et al. 2023

Bioactive Materials

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“…Due to its excellent mechanical properties and relatively good corrosion resistance, the WE43 alloy-one of the most potential magnesium alloys for clinical application has been extensively investigated. 10,27,28 Magnesium dissolves in water and generates Mg(OH) 2 and H 2 . 28 As the ionization reaction of HCO 3 À is greater in an alkaline environment than the hydrolysis reaction, the dissolution of CO 2 and the presence of HCO 3 À can act as a buffer for the alkaline environment.…”

Section: Discussionmentioning

confidence: 99%

Effect of unsoluble corrosion products of WE43 alloys in vitro on macrophages

Dong,

Shen,

Zhang

et al. 2023

J Biomedical Materials Res

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Magnesium alloys have been used to manufacture biodegradable implants, bone graft substitutes, and cardiovascular stents. WE43 was the most widely used magnesium alloy. The degradation process begins when the magnesium alloy stent is implanted in the body and comes into contact with body fluid. The degradation products include hydrogen, Mg2+, local alkaline environment, and unsoluble products. A large number of studies focused on Mg2+ and pH in vitro, and in vivo of magnesium alloys, but few studies on unsoluble corrosion products (UCPs). In this study, UCPs of WE43 alloy were prepared by immersion in vitro, and their effects on macrophages were investigated. The results showed that the unsoluble corrosion products were Mg24Y5, Mg12YNd, and MgCO3·3H2O, which were dose‐dependent on the apoptosis and necrosis of macrophages. After phagocytosis of UCPs, macrophages mainly metabolize in lysosome, and autophagy also participates in the metabolism of UCPs. It also decreases mitochondrial membrane potential and increases lysosomes, endoplasmic reticulum stress, and P2X7 receptor activation. These will increase reactive oxygen species (ROS) in cells, activating NLRP3 inflammatory corpuscles, activating the downstream pro‐IL18 and pro‐IL1β, and converting it to IL‐18, and IL‐1β. However, its pro‐inflammatory effect is far lower than that of the classical Lipopolysaccharide (LPS) pro‐inflammatory pathway. This work has increased our understanding of magnesium alloy metabolism and provides new ideas for the clinical application of magnesium alloys.

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Degradation behaviors and in-vivo biocompatibility of a rare earth- and aluminum-free magnesium-based stent

Cited by 22 publications

References 69 publications

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Advances in coatings on magnesium alloys for cardiovascular stents – A review

A “built-up” composite film with synergistic functionalities on Mg–2Zn–1Mn bioresorbable stents improves corrosion control effects and biocompatibility

Effect of unsoluble corrosion products of WE43 alloys in vitro on macrophages

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