Degenerative Spine Injury Associated With Back Pain: Morphogenetic Aspects

Правдюк, Н. Г.; Шостак, Н. А.

doi:10.17650/1818-8338-2017-11-3-4-17-22

Klinicist

2018

DOI: 10.17650/1818-8338-2017-11-3-4-17-22

|View full text |Cite

Degenerative Spine Injury Associated With Back Pain: Morphogenetic Aspects

Н. Г. Правдюк¹,

Н. А. Шостак²

Abstract: Дегенерация межпозвонкового диска (МПД)-патологический процесс, возникающий вследствие взаимодействия генетических и средовых факторов, обусловливающих структурное и функциональное повреждение МПД и смежных структур, и являющийся начальным этапом дегенеративного каскада в позвоночно-двигательном сегменте. В инициации и прогрессировании дегенеративных процессов МПД традиционно обсуждается участие нескольких факторов: неадекватной механической нагрузки, снижения диффузии питательных веществ через замыкательные п… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 29 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Cellular and molecular aspects of degenerative disc disease and potential strategies of biological therapy

Novikova¹,

Правдюк²,

Шостак³

2020

Klinicist

View full text Add to dashboard Cite

Back pain is one of the main global health problems with a high level of prevalence and patients’ disability. In most cases, it is associated with degenerative spine damage (degenerative disc disease), dorsopathy, discopathy (M51 and M53 according to the International Classification of Diseases, 10th revision), affecting all levels of the intervertebral disc (IVD) (cytological, chemical and biochemical) as a whole as well as biological molecules that regulate homeostasis of the disc intercellular substance (growth factors, pro-inflammatory cytokines, enzymes). A key point in IVD dehydration is that catabolic processes predominate over anabolic ones due to changed gene expression in the corresponding biologically active molecules, disc angiogenesis and neoinnervation of the structures of the fibrous ring and pulpous nucleus. The latter is responsible for chronic pain in patients.Cells supporting homeostasis in nucleus pulpous, chondrocytes, continuously synthesize and restore proteoglycans and hyaluronic acid in nucleus pulpous, restoring shock-absorbing functions of the vertebral-motor segment. Decreased activity and death of chondrocytes in the avascular disc structure is a serious problem for reparative medicine. In accordance with IVD molecular-cellular mechanisms, numerous approaches to treat degenerative disc disease are being developed, each of which, influencing one of the links in the pathogenesis, has a direct or indirect effect on IVD repair.The article describes morphology, pathogenesis and genetics of degenerative disc disease, as well as main modern strategies of biological therapy: tissue engineering, biologically active substances locally used in IVD matrix, including PRP therapy (Platelet Rich Plasma therapy), methods of gene (using the viral vector) and cell therapy, as well as experience in the local use of genetically engineered biological products. Most successful studies are a combination of cell and gene therapy with the use of synthesized matrices.

show abstract

Cellular and molecular aspects of degenerative disc disease and potential strategies of biological therapy

Novikova¹,

Правдюк²,

Шостак³

2020

Klinicist

View full text Add to dashboard Cite

show abstract

Modern views on the pathogenesis of intervertebral disc degeneration

Shnayder,

Trefilova,

Ashkhotov

et al. 2024

Klinicist

View full text Add to dashboard Cite

Introduction. Intervertebral disc (IVD) degeneration is defined as a multifactorial degenerative disease of the spine, starting from the structures of the nucleus pulposus of the IVD, spreading to the fibrous ring and other elements of the spinal motion segment. Unlike natural aging, a pathological degenerative process that occurs in IVDs as a result of the additive effect of genetic predisposition and external environmental factors leads to the formation of chronic back pain and reduces the patient’s quality of life. Despite many years of studying the problem of the pathogenesis of IVD degeneration, it is far from being resolved, which encourages us to further study the pathogenetic mechanisms of the development of this pathology.Aim. To update the knowledge of practicing neurologists about the results of modern studies of the leading mechanisms of development of IVD degeneration in humans and their role in the development of promising biomarkers of this pathology and new strategies for pathogenetic therapy.Materials and methods. A search and analysis of publications was carried out in Russian-language (e-Library) and Englishlanguage databases (PubMed, Oxford Press, Clinical Keys, Springer, Elsevier, Google Scholar). Search depth – 5 years (2018–2023).Results. The analyzed and generalized results of studies of the molecular mechanisms influencing the development and progression of this pathology are presented. The leading pathogenetic mechanisms for the development of IVD degeneration, such as oxidative stress and the NO system, cytokine imbalance, increased activity of matrix metalloproteinases, dysfunction of fibrillar collagens and proteoglycan, as well as their relationship with each other, were considered.Conclusion. The review provides a broader look at the pathogenetic mechanisms of IVD degeneration, which makes it possible to set new goals for future development of promising therapeutic strategies.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Degenerative Spine Injury Associated With Back Pain: Morphogenetic Aspects

Cited by 2 publications

References 29 publications

Cellular and molecular aspects of degenerative disc disease and potential strategies of biological therapy

Cellular and molecular aspects of degenerative disc disease and potential strategies of biological therapy

Modern views on the pathogenesis of intervertebral disc degeneration

Contact Info

Product

Resources

About