Degenerative joint disease in poultry — differences in composition and morphology of articular cartilage are associated with strain susceptibility

Anderson-MacKenzie, Janet M.; Hulmes, David J.S.; Thorp, B.H.

doi:10.1016/s0034-5288(97)90154-5

Cited by 10 publications

(9 citation statements)

References 13 publications

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“…Genetic selection for certain dog breeds (LaFond et al, 2002) or poultry strains (Anderson-Mackenzie et al, 1997;Velleman, 2000) is associated with predisposition to joint disease, but the influence of genetics on DJD development in waterfowl at this zoo is unknown. The large number of waterfowl species and small sample size within each species precluded statistical analyses of species or genetic predisposition to DJD.…”

Section: Discussionmentioning

confidence: 99%

“…Had we looked at the prevalence of DJD among living birds at FCZ, it is possible that we would have observed a higher number of DJD cases among older birds. Because commercial poultry rarely live beyond weeks or months, increased incidence of joint disease with age is rarely discussed as a risk factor in these birds, except among mature adult broiler-breeders that are susceptible to joint disease (Hocking et al, 1996), or in less susceptible laying hens, where DJD is uncommon except in older birds (Anderson-Mackenzie et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…These problems are often reported in young poultry that rarely live beyond 6 months of age. Many different risk factors and aetiologies have been documented in these birds, including infectious (Daoust, 1978;McNamee et al, 1998;Palya et al, 2003;Joiner et al, 2005), neoplastic (Rothschild & Panza, 2005), genetic (Anderson-Mackenzie et al, 1997), and dietary or husbandry-related causes (Huff et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Degenerative joint disease in captive waterfowl

2011

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Degenerative joint disease in captive waterfowl

2011

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“…Osteoarthritis, for example, as identified by the existence of osteophytes in the peri-articular joint space, has been found in up to 9.8% of pigeons and 3% of hawks (Rothschild and Panza 2006). Overweight turkeys, overweight chickens, and ostriches kept in small enclosures have been found to develop degenerative joint disease (cartilage fibrillation, fissuring, chondrocyte clustering, changes in proteoglycan content, and cartilage thinning) in both the hip and hock joints (Duff 1985;Duncan et al 1991;Anderson-Mackenzie et al 1997;Venkatesan et al 1999;AndersonMacKenzie et al 2001;Tomiosso et al 2005). Genetic, environmental, and nutritional factors contribute to the development of osteoporosis in laying hens, with a 30% incidence of fracture reported for these animals (Fleming et al 2000).…”

Section: Discussionmentioning

confidence: 99%

Hip joint contact force in the emu (Dromaius novaehollandiae) during normal level walking

Goetz

Derrick

Pedersen

et al. 2008

Journal of Biomechanics

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The emu is a large, (bipedal) flightless bird that potentially can be used to study various orthopaedic disorders in which load protection of the experimental limb is a limitation of quadrupedal models. An anatomy-based analysis of normal emu walking gait was undertaken to determine hip contact forces for comparison with human data. Kinematic and kinetic data captured for two laboratoryhabituated emus were used to drive the model. Muscle attachment data were obtained by dissection, and bony geometries were obtained by CT scan. Inverse dynamics calculations at all major lowerlimb joints were used in conjunction with optimization of muscle forces to determine hip contact forces. Like human walking gait, emu ground reaction forces showed a bimodal distribution over the course of the stance phase. Two-bird averaged maximum hip contact force was approximately 5.5 times body weight, directed nominally axially along the femur. This value is only modestly larger than optimization-based hip contact forces reported in literature for humans. The interspecies similarity in hip contact forces makes the emu a biomechanically attractive animal in which to model loading-dependent human orthopaedic hip disorders.

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“…If the signals were active, we would observe nuclear translocation and/or cytoplasmic accumulation of -catenin as seen in the hypertrophic zone in the growth plate. To test this prediction, we examined guinea pig cartilage from four month old and ten month old animals because these animals are a well-studied model of joint disease [46][47][48]. Guinea pigs invariably display OA symptoms in their knee joints with increasing age.…”

Section: Wnt/ -Catenin Signaling and Cartilage Matrix Remodelingmentioning

confidence: 99%

Wnt/β -Catenin Signaling in Chondrocyte Function and Cartilage Matrix Disruption

Enomoto‐Iwamoto¹,

Otani²,

Koike³

et al. 2006

CRR

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A fine balance between cartilage matrix synthesis and degradation is critical both for the maintenance of articular cartilage function and skeletal development and growth. Disruption of this balance causes abnormalities in skeletal formation and growth and leads to degenerative cartilage diseases, including osteoarthritis and rheumatoid arthritis. Previous studies from this and other laboratories have indicated that Wnt proteins regulate chondrocyte function and behavior and also play important roles in cartilage development and skeletogenesis, from the initial steps of chondrogenesis to the final steps during which calcified cartilage is replaced by bone. Inhibition of Wnt/ -catenin signaling suppresses chondrocyte maturation and endochondral ossification, while activation both inhibits cartilage matrix synthesis and accumulation and impairs growth plate organization and tissue integrity. We found that activation of Wnt/ -catenin signaling strongly stimulated proteoglycan loss from chondrocyte cultures and cartilage explants while upregulated the expression of genes responsible for cartilage matrix degradation. Furthermore, -catenin accumulates in chondrocytes located in osteoarthritic articular cartilage in a manner similar to that normally occurring in growth plate hypertrophic chondrocytes, suggesting that Wnt/ -catenin signaling is activated in regions where active matrix degradation occurs; thus, Wnt/ -catenin signaling may be a common pathway regulating matrix disruption during endochondral ossification and pathological degeneration of cartilage.

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Degenerative joint disease in poultry — differences in composition and morphology of articular cartilage are associated with strain susceptibility

Cited by 10 publications

References 13 publications

Degenerative joint disease in captive waterfowl

Degenerative joint disease in captive waterfowl

Hip joint contact force in the emu (Dromaius novaehollandiae) during normal level walking

Wnt/β -Catenin Signaling in Chondrocyte Function and Cartilage Matrix Disruption

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Degenerative joint disease in poultry — differences in composition and morphology of articular cartilage are associated with strain susceptibility

Cited by 10 publications

References 13 publications

Degenerative joint disease in captive waterfowl

Degenerative joint disease in captive waterfowl

Hip joint contact force in the emu (Dromaius novaehollandiae) during normal level walking

Wnt/&#946; -Catenin Signaling in Chondrocyte Function and Cartilage Matrix Disruption

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Wnt/β -Catenin Signaling in Chondrocyte Function and Cartilage Matrix Disruption