Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

Jahagirdar, Devashree; Bangde, Prachi; Jain, Ratnesh; Dandekar, Prajakta

doi:10.1002/biot.202100154

Cited by 9 publications

(5 citation statements)

References 121 publications

(153 reference statements)

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“…Numerical simulation has been recognized as an effective means of eye disease biomechanical research, but for most studies, the eye model is often simplified, and biomechanics analysis was conducted under ideal conditions without considering other factors, which may lead to the results deviation of the numerical analysis and the actual situation [ 107 ]. In recent years, researchers have shown great interest in alternatives to in vitro models of the eye (Table 3 ), allowing for the addition of dynamic fluid flows to better mimic the physiological structure of the eye [ 108 , 109 ].…”

Section: In Vitro Biomechanical Study Methods Of Eye Tissuementioning

confidence: 99%

Biomechanical analysis of ocular diseases and its in vitro study methods

Zhao

Yan

et al. 2022

BioMed Eng OnLine

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Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological processes. Studying the pathogenesis of various ocular diseases will be helpful for the diagnosis and treatment of ocular diseases. We provide a critical review of recent biomechanical analysis of ocular diseases including glaucoma, high myopia, and diabetes. And try to summarize the research about the biomechanical changes in ocular tissues (e.g., optic nerve head, sclera, cornea, etc.) associated with those diseases. The methods of ocular biomechanics research in vitro in recent years are also reviewed, including the measurement of biomechanics by ophthalmic equipment, finite element modeling, and biomechanical analysis methods. And the preparation and application of microfluidic eye chips that emerged in recent years were summarized. It provides new inspiration and opportunity for the pathogenesis of eye diseases and personalized and precise treatment.

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Section: In Vitro Biomechanical Study Methods Of Eye Tissuementioning

confidence: 99%

Biomechanical analysis of ocular diseases and its in vitro study methods

Zhao

Yan

et al. 2022

BioMed Eng OnLine

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“…Tissue-tissue interfaces, oxygen gradients, and the mechanically active tissue/organ microenvironment are examples of these. Because these cells/tissues flourish in the gel’s core, measuring physiologic diffusion gradients (for example, kidney ion transport) ( Figure 2 ) and polarized cellular products sampling is difficult (e.g., liver bile flow) ( Caballero et al, 2017 ; Kim et al, 2021b ; Jahagirdar et al, 2021 ; Yoon et al, 2021 ). Human drug testing outcomes are commonly unstable, as evidenced by the pharmaceutical industry.…”

Section: Design and Materialsmentioning

confidence: 99%

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

et al. 2023

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The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device cultured with human living cells under specific organ shear stress which can faithfully replicate human organ-body level pathophysiology. This emerging organ-on-chip platform can be a remarkable alternative for animal models with a broad range of purposes in drug testing and precision medicine. Here, we review the parameters employed in using organ on chip platform as a plot mimic diseases, genetic disorders, drug toxicity effects in different organs, biomarker identification, and drug discoveries. Additionally, we address the current challenges of the organ-on-chip platform that should be overcome to be accepted by drug regulatory agencies and pharmaceutical industries. Moreover, we highlight the future direction of the organ-on-chip platform parameters for enhancing and accelerating drug discoveries and personalized medicine.

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“…Disease-on-chip models, however, attract widespread interest due to their potential emulation of the disease microenvironment, regulatory factors, and physiological circumstances surrounding organs. The shear force applied by the environment, cell patterning, cell–cell communication, and other factors can be controlled for mimicking the organ and relevant diseases [ 274 ]. Furthermore, these platforms offer multi-omic analysis and investigation of the primary biophysical and chemical reasons for cancer formation and cellular-extracellular conditional growth microenvironment [ 275 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

Cited by 9 publications

References 121 publications

Biomechanical analysis of ocular diseases and its in vitro study methods

Biomechanical analysis of ocular diseases and its in vitro study methods

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Biomedical Applications of Microfluidic Devices: A Review

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