Degenerated boutons in the fundus striati (nucleus accumbens septi) after lesion of the parafascicular nucleus in the cat

Chung, J. W.; Häßler, R.; Wagner, Alexander

doi:10.1007/bf00226045

Cited by 14 publications

(2 citation statements)

References 11 publications

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“…9 appears similar to the type IV boutons of Hassler et al (7). They considered that this type is a bouton from the centro-median-parafascicular complex off the thalamus, which is suggested to be cholinergic (41) and to terminate on spines of a medium-sized neuron (28,30) (type I ChAc positive neuron in the present study).…”

Section: Resultssupporting

confidence: 85%

Ultracytochemistry of Choline Acetyltransferase in the Neostriatum of the Rat Brain

Kaiya

Iwata

Namba

et al. 1979

Acta Histochem. Cytochem

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Section: Resultssupporting

confidence: 85%

Ultracytochemistry of Choline Acetyltransferase in the Neostriatum of the Rat Brain

Kaiya

Iwata

Namba

et al. 1979

Acta Histochem. Cytochem

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“…Cortical terminals form asymmetric synapses primarily with dendritic spines of the medium-sized densely spiny projection neurons (Kemp & Powell, 1971a, b, c, d;Bak et al, 1975;Hassler et al, 1978;Somogyi et al, 1981;Smith & Bolam, 1990;Smith et al, 1998), and also with the dendrites of interneurons (Bolam & Bennett, 1995). Chung et al (1976Chung et al ( , 1977 and Dube et al (1988) found thalamostriatal boutons establishing asymmetrical synapses on dendritic spines.…”

Section: Introductionmentioning

confidence: 98%

Age-Related Changes in the Synapses of the Rat' Neostriatum

Itzev

Lolova

Lolov

et al. 2001

Archives of Physiology and Biochemistry

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By means of transmission electron microscopy, the age-related changes in axospinous (ASS) and axodendritic (ADS) synapses in the dorsal part of the rostral neostriatum in two groups of Wistar rats: young (3-month-old), and senescent (25-month-old) were examined. The changes in different parameters, characterizing the ASS and ADS: synaptic density (SD), number of synaptic vesicles (SV), number of synaptic contact zone (SCZ), and number of dendritic spines, bearing synapses (DS) were investigated morphometrically. The SD of the ASS decreased significantly during aging, but the SD of the ADS did not changed significantly. The mean area of the synaptic boutons increased significantly during aging in two types of synapses. The mean number of vesicles per synaptic bouton increased, but the number of vesicles per microm2 of synaptic bouton, and per microm3 of the neuropil decreased. The mean SCZ length increased in both types of synapses. The total SCZ length per 1000 microm2 of the neuropil, and the total area of the SCZ per 1000 microm3 of the neuropil decreased in ASS, but the same parameters of the ADS did not changed significantly. The mean number of synaptic DS per 1000 microm2 of the neropil decreased during aging, but the mean area of the synaptic DS increased. The present results support the hypothesis that the synaptic contacts change significantly during aging, and the ASS are more vulnerable during aging than the ADS.

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Efferent connections of the centromedian and parafascicular thalamic nuclei in the squirrel monkey: A light and electron microscopic study of the thalamostriatal projection in relation to striatal heterogeneity

Sadikot

Parent

Smith

et al. 1992

J of Comparative Neurology

264

174

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The organization of the thalamostriatal projections arising from the centromedian (CM) and parafascicular (Pf) thalamic nuclei in the squirrel monkey (Saimiri sciureus) was studied at both light and electron microscopic levels. Following selective injections of the anterograde axonal tracer Phaseolus vulgaris-leucoagglutinin (PHA-L) into the CM or Pf, patterns of terminal arborization within the striatum were compared to the biochemical heterogeneity of the striatum as revealed by immunohistochemical staining for the calcium-binding protein calbindin D-28k (CaBP), and histochemical staining for the enzymes acetylcholinesterase (AChE) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-diaphorase). The PHA-L-labeled axon terminals within the striatum were further analyzed at the ultrastructural level to characterize their pattern of synaptic organization. Dense and heterogeneous terminal fields occur in the "sensorimotor" territory of the striatum after CM injections, or in the "associative" striatal territory following Pf injections. In the associative territory labeled axons arborize in a diffuse manner predominantly within areas enriched with CaBP, AChE, or NADPH-diaphorase, representing the matrix compartment, and tend to avoid areas poor in these substances, corresponding to the patch/striosome compartment. In the sensorimotor territory labeled axons form bands that occupy a subregion of the NADPH-diaphorase-rich zone in the putamen. The terminal pattern of the CM-striatal projection suggests the existence of a more complex mosaic organization within the sensorimotor territory. Ultrastructural analysis of PHA-L-labeled elements within the striatum reveals that both CM and Pf projections form asymmetric synapses upon dendrites and spines of striatal cells. A total of 339 PHA-L-labeled boutons were examined after CM injections and compared to 293 boutons following Pf injections. After CM injections, 29% of PHA-L-labeled terminals form synapses on dendritic spines and 66% on dendritic shafts, whereas after Pf injections only 12% of synapses occur on dendritic spines compared to 81% on dendritic shafts. Labeled terminals forming axosomatic or axoaxonic synapses were not seen within the striatum following either CM or Pf injections. It is concluded that in the squirrel monkey: 1) Pf-striatal fibers profusely arborize within the matrix compartment of the associative territory, 2) CM-striatal fibers form bands that occupy a subregion of the NADPH-diaphorase-rich zone within the sensorimotor territory, and 3) that both Pf- and CM-striatal projections establish asymmetric synapses with dendrites and spines of medium-sized spiny cells.(ABSTRACT TRUNCATED AT 400 WORDS)

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Degenerated boutons in the fundus striati (nucleus accumbens septi) after lesion of the parafascicular nucleus in the cat

Cited by 14 publications

References 11 publications

Ultracytochemistry of Choline Acetyltransferase in the Neostriatum of the Rat Brain

Ultracytochemistry of Choline Acetyltransferase in the Neostriatum of the Rat Brain

Age-Related Changes in the Synapses of the Rat' Neostriatum

Efferent connections of the centromedian and parafascicular thalamic nuclei in the squirrel monkey: A light and electron microscopic study of the thalamostriatal projection in relation to striatal heterogeneity

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