Degenerate‐disc Infection Study with Contaminant Control: Discussion on the Research Methods

Rao, Prashanth J.; Chau, Christine; Phan, Kevin; Mobbs, Ralph J.

doi:10.1111/os.12366

Cited by 2 publications

(1 citation statement)

References 19 publications

(29 reference statements)

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“…Cultures from disk materials and from ligamentum flavum and paraspinal musculature were performed. 23 Patients with culture positivity in both the disk material and the paraspinal musculature were interpreted as contaminants. A pilot report of the first 168 patients noted that 19.6% had disk-only positive cultures with negative controls, with C acnes present in 50% of these cultures, followed by Streptococcus species.…”

Section: Contamination or Infection? Studies With Contaminant Controlsmentioning

confidence: 99%

The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data

Iyer

Louie

Nolte

et al. 2019

J Am Acad Orthop Surg

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Low back pain resulting from intervertebral disk degeneration is a cause of substantial disability and productivity loss. Over the past few years, growing evidence exists which suggests that low-grade bacterial infection, particularly infection with Cutibacterium acnes, may be associated with degenerative disk disease in the lumbar spine. Positive cultures are obtained in approximately 30% of intervertebral disk specimens removed at the time of surgery. In addition, one randomized trial has shown that antibiotic therapy for low back pain in patients with disk degeneration can slow the progression of degeneration and improve pain and disability levels. Although these results are encouraging, the link between infection and disk degeneration remains controversial. Investigators have attempted to address the limitations of clinical research by using translational methods and animal models. These methods have shown that seeding of the disk with bacteria can lead to increased local inflammation and an in vivo phenotype that is similar to human disk degeneration. This review seeks to provide an overview of the clinical, translational, and animal model data linking infection to disk degeneration. We review mechanisms for disk degeneration in the setting of infection and explore areas for future investigation.

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Section: Contamination or Infection? Studies With Contaminant Controlsmentioning

confidence: 99%

The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data

Iyer

Louie

Nolte

et al. 2019

J Am Acad Orthop Surg

View full text Add to dashboard Cite

show abstract

Degenerate-disc infection study with contaminant control (DISC): Application of a proposed histological scoring system

Rao

Maharaj

Tang

et al. 2019

Journal of Clinical Neuroscience

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Degenerate‐disc Infection Study with Contaminant Control: Discussion on the Research Methods

Abstract: Future large-scale studies are required with a good control arm, a contamination arm, and histopathological correlations.

Cited by 2 publications

References 19 publications

The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data

The Relationship Between Low-Grade Infection and Degenerative Disk Disease: A Review of Basic Science and Clinical Data

Degenerate-disc infection study with contaminant control (DISC): Application of a proposed histological scoring system

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