The overproduction of HOCl is highly correlated with diseases such as atherosclerosis,rheumatoid arthritis,and cancer.Whilst acting as amarker of these diseases,HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease.Int his work, anew platform of HOCl probes has been developed that integrates detection, imaging,a nd therapeutic functions.T he probes can detect HOCl, using both NIR emission and the naked eye in vitro,w ith high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover,the probes provided by this platform can rapidly release either amino-or carboxycontaining compounds from prodrugs,during HOCl detection and imaging,t orealize at herapeutic effect. Figure 1. a) Our previous work. b) The design strategyo fthis work. Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.