Deformation properties of pharmaceutical excipients determined using an in-die and out-die method

Ilić, Ilija; Govedarica, Biljana; Šibanc, Rok; Dreu, Rok; Srčič, Stanko

doi:10.1016/j.ijpharm.2013.02.001

Cited by 72 publications

(26 citation statements)

References 24 publications

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“…The calculated yield pressure value of the CFIB was 89.9 ±3.2 MPa, which is a value typical of a material that shows a predominantly plastic deformation mechanism when subjected to a compression process inside a confined space. This behavior has been observed for many other polysaccharides such as MCC (37)(38)(39)(40), several types of starch (39)(40)(41), or pectin (40).…”

Section: Evaluation Of Compaction Behaviorsupporting

confidence: 54%

Evaluation of Citrus Fibers as a Tablet Excipient

et al. 2013

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Abstract. The consumption of fibers is associated with many health benefits, such as a reduction of cardiovascular and gastrointestinal diseases, control of body weight, and prevention of diabetes. Despite the widespread use of fiber supplements such as capsules or tablets, there is an almost complete lack of information concerning the technological properties of functional fibers used in nutraceutical formulations. The aim of this work was to characterize the technological properties of citrus fibers necessary for their use as a processing aid in tableting. The results obtained showed that citrus fibers share many properties of other polysaccharides used as tableting excipients, such as thermal behavior and compaction mechanism, together with an appreciable tabletability. However, the most interesting properties resulted from their disintegration power. Citrus fibers behaved in a similar manner to the well-known super disintegrant croscarmellose sodium and resulted to be little susceptible to their concentration, to lubricant type, and lubricant concentration. Thus, this work supports the idea of a potential use of citrus fibers as "active" substances and processing aid in the tableting of nutraceutical products and also as functional excipient in pharmaceutical tablets formulation.

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Section: Evaluation Of Compaction Behaviorsupporting

confidence: 54%

Evaluation of Citrus Fibers as a Tablet Excipient

et al. 2013

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“…As depicted above in Table 6, the friability of tablets significantly decreased as the compression force increased (P � 0.0134). is might be due to the plastic deformation ability of microcrystalline cellulose and PEG 6000 at high compression force which could facilitate the formation of harder and less friable tablets as rationalized by Ilic et al [24]. In contrast, the disintegration time significantly increased (P � 0.0045) with compression force.…”

Section: Effects Of Compression Forcementioning

confidence: 92%

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Belayneh

Molla

Kahsay

2020

Advances in Pharmacological and Pharmaceutical Sciences

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e treatment of type II DM involves the use of combination of drugs, especially at the chronic stage. However, the pill burden of this combination therapy combined with swallowing difficulties, occurring at a later stage of DM, has been the major challenge for successful treatment outcomes. is study was aimed at formulating and optimizing a monolithic fixed-dose combination (FDC) of metformin (MET) and glibenclamide (GLB) orodispersible tablets (ODTs) to overcome both the pill burden and swallowing problems. e FDC ODTs were prepared by the melt granulation technique using polyethylene glycol (PEG) 6000 as a binding agent and crospovidone as a superdisintegrant. In the preliminary study, the effects of sodium lauryl sulphate (SLS), PEG 6000, crospovidone, and compression force on friability, disintegration time, and drug release of tablets were investigated. e FT-IR studies showed that there were no incompatibilities between MET and GLB as well as within excipients. e preliminary studies revealed that PEG 6000 and compression force significantly affect both the friability and the disintegration time, while SLS and crospovidone only affect the disintegration time. erefore, the effects of PEG 6000, crospovidone, and compression force were further studied and optimized using the central composite design. Accordingly, the most desirable optimal values were obtained at 3.82% of PEG 6000, 9.83% of crospovidone, and 10.6 kN compression force having a friability of 0.302% and a disintegration time of 18.7 seconds. From these results, it can be concluded that a monolithic FDC of MET and GLB ODTs having adequate mechanical strength and faster disintegration time was successfully formulated.

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“…Some criticisms have been recorded against the Heckel model with regards to its accuracy and robustness (Sonnergaard, 1999). Contrastingly, the Walker model is more robust and less sensitive to the approach used (Ilić et al, 2013). Notwithstanding, Heckel and Walker analysis have been able to predict and determine optimum tableting properties usually obtained with plastic and brittle fracture deforming materials (Alakayleh et al, 2016).…”

Section: Fig 4 Compaction Plots Of Sas-cd Sas-cf and Sas-cg (A) Hmentioning

confidence: 99%

Comparative analysis of co-processed starches prepared by three different methods

Apeji¹,

Aluga²,

Olayemi³

et al. 2017

British Journal of Pharmacy

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Co-processing is currently of interest in the generation of high-functionality excipients for tablet formulation. In the present study, comparative analysis of the powder and tableting properties of three co-processed starches prepared by three different methods was carried out. The co-processed excipients consisting of maize starch (90%), acacia gum (7.5%) and colloidal silicon dioxide (2.5%) were prepared by co-dispersion (SAS-CD), co-fusion (SAS-CF) and co-granulation (SAS-CG). Powder properties of each co-processed excipient were characterized by measuring particle size, flow indices, particle density, dilution potential and lubricant sensitivity ratio. Heckel and Walker models were used to evaluate the compaction behaviour of the three co-processed starches. Tablets were produced with paracetamol as the model drug by direct compression on an eccentric Tablet Press fitted with 12 mm flat-faced punches and compressed at 216 MPa. The tablets were stored at room temperature for 24 h prior to evaluation. The results revealed that cogranulated co-processed excipient (SAS-CG) gave relatively better properties in terms of flow, compressibility, dilution potential, deformation, disintegration, crushing strength and friability. This study has shown that the method of coprocessing influences the powder and tableting properties of the co-processed excipient.

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Deformation properties of pharmaceutical excipients determined using an in-die and out-die method

Cited by 72 publications

References 24 publications

Evaluation of Citrus Fibers as a Tablet Excipient

Evaluation of Citrus Fibers as a Tablet Excipient

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Comparative analysis of co-processed starches prepared by three different methods

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