Deformation of vesicles flowing through capillaries

Vitkova, Victoria; Mader, Maud-Alix; Podgorski, Thomas

doi:10.1209/epl/i2004-10211-9

Cited by 64 publications

(79 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The latter stage has been described in several papers. [14][15][16] Migration in Poiseuille flows has been also reported on capsules, [17][18][19] red blood cells, 18,19 and drops. 20,21 The latter seem to have a very different behavior: Depending on the viscosity ratio and the confinement, the reported equilibrium positions are not always on the centerline.…”

mentioning

confidence: 76%

Noninertial lateral migration of vesicles in bounded Poiseuille flow

et al. 2008

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 76%

Noninertial lateral migration of vesicles in bounded Poiseuille flow

et al. 2008

View full text Add to dashboard Cite

show abstract

“…which can be called a 'capillary number' since the extension modulus has the dimension of a capillary surface tension (Vitkova et al 2004). …”

Section: Elongation and Tension Of A Vesicle In A Shear Flowmentioning

confidence: 99%

Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles

2008

View full text Add to dashboard Cite

Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the local tension becomes negative, leading to buckling and tip formation near a pole of the vesicle. We experimentally check these predictions in the case of strong acoustic streaming flow generated near ultrasounddriven microbubbles, such as those used in medical applications.

show abstract

“…There are many potential applications such as blood diagnosis on chip. Under steady flows in homogeneous glass capillaries and rectangular microchannels, vesicles [15] and RBCs [14,[16][17][18] deform into a bullet (with a flattened rear end) or parachute (with an inside bulge at the rear end) shape. Compared to these steadyflow conditions, the vesicle dynamics in time-dependent flow is much less explored.…”

mentioning

confidence: 99%

Dynamics of fluid vesicles in flow through structured microchannels

et al. 2010

View full text Add to dashboard Cite

Abstract. -The dynamics of fluid vesicles is studied under flow in microchannels, in which the width varies periodically along the channel. Three types of flow instabilities of prolate vesicles are found. For small quasi-spherical vesicles -compared to the average channel width -perturbation theory predicts a transition from a state with orientational oscillations of a fixed prolate shape to a state with shape oscillations of symmetrical ellipsoidal or bullet-like shapes with increasing flow velocity. Experimentally, such orientational oscillations are observed during the slow migration of a vesicle towards the centerline of the channel. For larger vesicles, mesoscale hydrodynamics simulations and experiments show similar symmetric shape oscillation at reduced volumes V * 0.9. However, for non-spherical vesicles with V * 0.9, shapes are found with two symmetric or a single asymmetric tail.Introduction. -Soft deformable objects such as liquid droplets, vesicles, and cells show a complex behavior under flow. For example, in simple shear flow, fluid vesicles exhibit tank-treading, tumbling, and swinging (also called vacillating-breathing, or trembling) motions, depending on parameters such as shear rate, viscosity contrast, and internal volume [1][2][3][4][5][6][7][8][9]. Understanding the flow behavior of lipid vesicles and red blood cells (RBCs) is not only an interesting problem of the hydrodynamics of deformable, thermally fluctuating membranes, but is also important for medical applications. In microcirculation, the deformation of RBCs reduces the flow resistance of microvessels. In diseases such as sickle cell anemia, RBCs have reduced deformability and often block microvascular flow [10]. Lipid vesicles are considered as a simple model of RBCs and also have applications as drug-delivery systems.The recent development of microfluidic techniques [11] allows the investigation and manipulation of individual

show abstract

Deformation of vesicles flowing through capillaries

Cited by 64 publications

References 16 publications

Noninertial lateral migration of vesicles in bounded Poiseuille flow

Noninertial lateral migration of vesicles in bounded Poiseuille flow

Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles

Dynamics of fluid vesicles in flow through structured microchannels

Contact Info

Product

Resources

About