Deflection cantilever detection of interferon gamma

Hurk, Remko van den; Evoy, Stéphane

doi:10.1016/j.snb.2012.09.023

Cited by 12 publications

(6 citation statements)

References 31 publications

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“…The high strength and low surface roughness of the material allowed the realization of cantilevers as thin as 4.3 nm. More recently, the fabrication of conductive nanocomposite AlMo membranes as thin as 28 nm and high fracture strength has also been reported [ 51 ]. The properties of the Al/0.32Mo (i.e.…”

Section: Introductionmentioning

confidence: 99%

Low Temperature Reactive Sputtering of Thin Aluminum Nitride Films on Metallic Nanocomposites

Ramadan

Evoy

2015

PLoS ONE

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Piezoelectric aluminum nitride thin films were deposited on aluminum-molybdenum (AlMo) metallic nanocomposites using reactive DC sputtering at room temperature. The effect of sputtering parameters on film properties was assessed. A comparative study between AlN grown on AlMo and pure aluminum showed an equivalent (002) crystallographic texture. The piezoelectric coefficients were measured to be 0.5±0.1 C m-2 and 0.9±0.1 C m-2, for AlN deposited on Al/0.32Mo and pure Al, respectively. Films grown onto Al/0.32Mo however featured improved surface roughness. Roughness values were measured to be 1.3nm and 5.4 nm for AlN films grown on AlMo and on Al, respectively. In turn, the dielectric constant was measured to be 8.9±0.7 for AlN deposited on Al/0.32Mo seed layer, and 8.7±0.7 for AlN deposited on aluminum; thus, equivalent within experimental error. Compatibility of this room temperature process with the lift-off patterning of the deposited AlN is also reported.

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Section: Introductionmentioning

confidence: 99%

Low Temperature Reactive Sputtering of Thin Aluminum Nitride Films on Metallic Nanocomposites

Ramadan

Evoy

2015

PLoS ONE

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“…Deflection-based mechanical sensors have been exploited for the detection of biomarkers, toxins and pathogenic organisms. Van den Hurk et al [ 29 ] have used silicon cantilever arrays to detect γ-interferon, an important biomarker protein for monitoring multiple sclerosis. The surface of the silicon cantilevers were functionalized with antibody using glutaraldehyde, Prolinker B and 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC)/N-hydroxysulfosuccinimide (Sulfo-NHS) linking procedures.…”

Section: Overview Of Detection Methods In Microfluidic Devicesmentioning

confidence: 99%

Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications

Pires

Dong

Hanke

et al. 2014

Sensors

246

148

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The field of microfluidics has yet to develop practical devices that provide real clinical value. One of the main reasons for this is the difficulty in realizing low-cost, sensitive, reproducible, and portable analyte detection microfluidic systems. Previous research has addressed two main approaches for the detection technologies in lab-on-a-chip devices: (a) study of the compatibility of conventional instrumentation with microfluidic structures, and (b) integration of innovative sensors contained within the microfluidic system. Despite the recent advances in electrochemical and mechanical based sensors, their drawbacks pose important challenges to their application in disposable microfluidic devices. Instead, optical detection remains an attractive solution for lab-on-a-chip devices, because of the ubiquity of the optical methods in the laboratory. Besides, robust and cost-effective devices for use in the field can be realized by integrating proper optical detection technologies on chips. This review examines the recent developments in detection technologies applied to microfluidic biosensors, especially addressing several optical methods, including fluorescence, chemiluminescence, absorbance and surface plasmon resonance.

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“…But the LOD of their sensors is 10 ng/mL, still remaining several orders of magnitude larger than desirable for clinical use. In a more recent study, van den Hurk and Evoy [43] investigated the impact of selection of linker molecules on the sensitivity of deflection microcantilever measurements of IFN-γ in PBS buffer. They found linking procedures using gluteraldehyde and prolinker B are effective to yield better sensitivity.…”

Section: Label-free Cytokine Biosensingmentioning

confidence: 99%

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

Chen

Huang

Chung

et al. 2015

Advanced Drug Delivery Reviews

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Systemic inflammatory disorders resulting from infection, trauma, surgery, and severe disease conditions pose serious threats to human health leading to organ dysfunction, organ failure, and mortality. The highly complex and dynamic nature of the immune system experiencing acute inflammation makes immunomodulatory therapy blocking pro-inflammatory cytokines very challenging. Successful therapy requires the ability to determine appropriate anti-cytokine drugs to be delivered at a right dose in a timely manner. Label-free micro- and nano-biosensors hold the potential to overcome the current challenges, enabling cytokine-targeted treatments to be tailored according to the immune status of an individual host with their unique cytokine biomarker detection capabilities. This review studies the recent progress in label-free cytokine biosensors, summarizes their performances and potential merits, and discusses future directions for their advancements to meet challenges towards personalized anti-cytokine drug delivery.

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Deflection cantilever detection of interferon gamma

Cited by 12 publications

References 31 publications

Low Temperature Reactive Sputtering of Thin Aluminum Nitride Films on Metallic Nanocomposites

Low Temperature Reactive Sputtering of Thin Aluminum Nitride Films on Metallic Nanocomposites

Recent Developments in Optical Detection Technologies in Lab-on-a-Chip Devices for Biosensing Applications

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

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