Definitive Carbon-Ion Radiation Therapy for Locally Advanced Sinonasal Malignant Tumors: Subgroup Analysis of a Multicenter Study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS)

Koto, Masashi; Demizu, Yusuke; Shimada, Hirofumi; Suefuji, Hiroaki; Tsuji, Hiroshi; Okimoto, Tomoaki; Ohno, Tatsuya; Shioyama, Yoshiyuki; Ikawa, Hiroaki; Nemoto, Kenji; Nakano, Takashi; Kamada, Tadashi

doi:10.1016/j.ijrobp.2018.05.074

Cited by 53 publications

(64 citation statements)

References 32 publications

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“…8 One of the possible explanation of achieving less local control in the current study as compared to previous C-ion RT report of sinonasal cancers 8 can be suboptimal coverage of target volume because of close proximity of target volume to critical OARs. Apart from the nasal cavity, majority of the patients had maxillary sinus and ethmoid sinus involvement (40%).…”

Section: Discussionmentioning

confidence: 53%

“…The 2 and 5 years local control rates were 84.1% and 71.2%, respectively. 8 One of the possible explanation of achieving less local control in the current study as compared to previous C-ion RT report of sinonasal cancers 8 can be suboptimal coverage of target volume because of close proximity of target volume to critical OARs. It could be substantiated by the fact that patients who received GTV Dmin0.1cc ≥ 52Gy (RBE) (n = 11) had shown a trend toward improved local control as compared to patients with GTV Dmin0.1cc < 52 Gy (RBE) (n = 11), although it was not statistically significant.…”

Section: Discussionmentioning

confidence: 54%

“…Thinking of radioresistance of non-SCCs of sphenoid sinus and the close proximity of the target volume to critical structures, carbon-ion radiotherapy (C-ion RT) seems to be a promising curable option for many inoperable primary non-SCCs owing to its unique physical dose distribution and enhanced biological effectiveness. 8,9 We report here a retrospective analysis of patients with primary sphenoid sinus malignancies who were treated with C-ion RT.…”

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes and toxicities of carbon‐ion radiotherapy in malignant tumors of the sphenoid sinus

et al. 2019

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Background: Most of the primary sphenoid sinus tumors present with locally advanced stages with involvement of adjacent critical structures and are not amenable to radical resection. We sought to evaluate the safety and efficacy of carbonion radiotherapy (C-ion RT) for sphenoid sinus malignancies. Methods: This is a retrospective analysis of 22 patients of primary sphenoid carcinomas treated with definitive C-ion RT. Results: Adenoid cystic carcinoma was the most common histology (15 patients, 68.2%). The median follow-up of this cohort was 48.5 months. The actuarial local control and overall survival at 5 years were 51.0% and 62.7%, respectively. Grade 4 visual impairment and grade 4 brain necrosis were seen in six and one patient, respectively. Conclusion: C-ion RT can provide a reasonably good clinical outcome in locally advanced sphenoid sinus malignancies with a marginally higher late toxicity profile because of extremely close proximity of the target volume to critical structures. K E Y W O R D Scarbon-ion radiotherapy, head and neck cancer, sphenoid sinus malignancy

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Long‐term outcomes and toxicities of carbon‐ion radiotherapy in malignant tumors of the sphenoid sinus

et al. 2019

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“…Our multicenter study (J-CROS 1402 HN) showed that CIRT was effective and safe for head and neck malignancies, particularly including radioresistant tumors. [9][10][11][12][23][24][25] Since April 2018, the public health insurance system in Japan has covered CIRT for head and neck malignancies, with the exception of radiosensitive oral, laryngeal, and pharyngeal squamous cell carcinoma.…”

Section: T a B L E 3 Univariate Analysis For Localmentioning

confidence: 99%

A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas

et al. 2018

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BackgroundWe conducted a retrospective multicenter study to assess the clinical outcomes of carbon‐ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon‐Ion Radiation Oncology Study Group [J‐CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas.MethodsThirty‐one patients treated with CIRT at four Japanese institutions were analyzed. Fourteen patients (45.2%) had squamous cell carcinomas, 13 (41.9%) had adenoid cystic carcinomas, and four (12.9%) had other types. Nineteen (61.3%), six (19.4%), three (9.7%), and three (9.7%) patients had T4, T3, T2, and T1 disease, respectively. All patients had N0M0 status. The median radiation dose was 64 Gy (relative biological effectiveness) in 16 fractions. The median gross tumor volume was 33.3 mL.ResultsThe median follow‐up period was 18.4 months (range, 5.1‐85.6). The 1‐ and 3‐year local control and overall survival rates were 75.0% and 55.0% and 79.3% and 58.7%, respectively. Regarding grade 3 or higher toxicities, three patients (9.7%) had grade 3 dermatitis, one (3.2%) had grade 3 mucositis, and two (6.5%) had grade 3 central nervous necrosis (ie, radiation‐induced brain necrosis). No grade 4 or worse reactions were observed.ConclusionCIRT was effective for EAC and ME carcinomas.

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“…Theoretically, C‐ion RT has a potential advantage for non‐squamous cell malignant tumors of the nasopharynx in reducing toxicity by sparing critical organs adjacent to the nasopharynx and its higher probability of control of photon‐resistant tumors. Recently, there has been increasing evidence of its efficacy and safety for head and neck malignant tumors . However, to date, there are no reports of C‐ion RT for non‐squamous cell malignant tumors of the nasopharynx.…”

Section: Introductionmentioning

confidence: 99%

A multi‐institutional retrospective study of carbon‐ion radiotherapy for non‐squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon‐Ion Radiation Oncology Study Group study 1402 HN

et al. 2018

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BackgroundThis multi‐institutional retrospective study focused on the clinical outcome of carbon‐ion radiotherapy (C‐ion RT) for non‐squamous cell malignant tumors of the nasopharynx.MethodsThe Japan Carbon‐ion Radiation Oncology Study Group collected and analyzed data for 43 patients with non‐squamous cell malignant tumors of the nasopharynx treated with C‐ion RT at four institutions in Japan.ResultsTwenty‐nine patients had adenoid cystic carcinomas, seven had malignant melanomas, three had adenocarcinomas, two had mucoepidermoid carcinomas, and two had other pathologies. Twenty‐six of the 43 patients (61%) had T4 tumors. The most common dose‐fractionation schedule was 64 Gy (relative biological effectiveness) in 16 fractions. The median follow‐up period was 30 months. The 2‐year local control (LC) and overall survival (OS) rates were 88% and 84%, respectively. For late toxicity, one patient developed grade 4 optic nerve disorder and two developed grade 5 pharyngeal hemorrhage. Actual incidence of grade 3 or higher late adverse events was 19%, and included cranial nerve dysfunction, jaw bone necrosis, central nervous system necrosis, and ear inflammation.ConclusionsC‐ion RT provided good LC and OS rates with acceptable toxicity for treatment of non‐squamous cell malignant tumors of the nasopharynx.

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Definitive Carbon-Ion Radiation Therapy for Locally Advanced Sinonasal Malignant Tumors: Subgroup Analysis of a Multicenter Study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS)

Abstract: The results of our multicenter study have demonstrated that C-ion RT can provide excellent clinical outcomes with acceptable late toxicities in patients who have locally advanced sinonasal malignant tumors.

Cited by 53 publications

References 32 publications

Long‐term outcomes and toxicities of carbon‐ion radiotherapy in malignant tumors of the sphenoid sinus

Long‐term outcomes and toxicities of carbon‐ion radiotherapy in malignant tumors of the sphenoid sinus

A retrospective multicenter study of carbon‐ion radiotherapy for external auditory canal and middle ear carcinomas

A multi‐institutional retrospective study of carbon‐ion radiotherapy for non‐squamous cell malignant tumors of the nasopharynx: Subanalysis of Japan Carbon‐Ion Radiation Oncology Study Group study 1402 HN

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