Definition of Sensitive Skin: An Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch

Miséry, Laurent; Ständer, Sonja; Szepietowski, Jacek C.; Reich, Adam; Wallengren, Joanna; Evers, Andrea W M; Takamori, Kenji; Brenaut, E.; Gall‐Ianotto, Christelle Le; Fluhr, Joachim W.; Berardesca, Enzo; Weißhaar, Elke

doi:10.2340/00015555-2397

Cited by 156 publications

(209 citation statements)

References 27 publications

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“…The only significant difference was a higher VAS score for itch at 30 min after stimulation. The occurrence of increased sensory perceptions in SS is in agreement with the results reported by previous clinical studies [18,19,20], and it has been recognized by the International Forum for the Study of Itch, which has recently initiated a special interest group on SS [30]. On the other hand, in contrast to the aberrant vascular reactions in SS reported previously [20], we could not detect differences in skin redness measured by the a* value or in the extent of the wheal-and-flare reaction measured by image analysis.…”

Section: Discussionsupporting

confidence: 81%

Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel

Falcone

Uzunbajakava²,

Richters³

et al. 2017

Skin Pharmacol Physiol

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Background/Aims: Histamine iontophoresis is known to elicit itch and a wheal-and-flare reaction; however, its impact on the skin barrier and underlying compartments has not been thoroughly evaluated yet. The primary objective of this study was to characterize that using immunohistochemistry, biophysical measurements, and image analysis, and secondly, to explore whether skin reactions to this model differ in sensitive skin (SS). Methods: Eighteen healthy subjects, n = 9 with SS and n = 9 with non-sensitive skin (NSS), were included based on a perception-based questionnaire. Histamine iontophoresis was performed on the buttock, and skin reactions were evaluated up to 72 h after stimulation. Results: The wheal-and-flare peaked at 30 min; after 8 h, no clinical signs were visible. No signs of disruption of the stratum corneum, as well as no increase in the number of Ki67-positive cells emerged, whereas fewer tryptase-positive mast cells and increased epidermal thickness were observed at 1 and 72 h, respectively. SS subjects showed higher perception of itch compared to NSS subjects. Conclusion: Histamine iontophoresis is a well-standardized in vivo model to quantitatively study the early stages of cutaneous inflammation with minimal impact on the skin barrier. In line with previous studies, it highlighted increased sensory perceptions in SS.

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Section: Discussionsupporting

confidence: 81%

Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel

Falcone

Uzunbajakava²,

Richters³

et al. 2017

Skin Pharmacol Physiol

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“…2 Consequently, the diagnosis and assessment of SS are mainly performed by interviewing subjects. 2 Consequently, the diagnosis and assessment of SS are mainly performed by interviewing subjects.…”

Section: Discussionmentioning

confidence: 99%

Triggering factors in sensitive skin from the worldwide patients’ point of view: a systematic literature review and meta‐analysis

Brenaut

Barnetche

Roudot³

et al. 2019

Acad Dermatol Venereol

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Sensitive skin (SS) is a syndrome defined by the occurrence of unpleasant sensations in response to stimuli that normally should not provoke such sensations. In most patients, symptoms occur within 1 h following exposure to trigger factors and may persist for minutes or even hours. Numerous triggering factors (physical, chemical or psychological) are suspected and described in articles. The aim of this article was to perform a systematic literature review to collect data on the triggering factors involved in SS and to then perform a meta‐analysis. Thirteen studies were included in the systematic literature review. Subjects were classified into groups, SS or no sensitive skin (NSS), and triggering factors were researched through responses to different questions. SS could be triggered by numerous factors. The most important triggering factor was cosmetics, with an odds ratio (OR) equal to 7.12 [3.98–12.72]. Other triggering factors were physical (variations in temperature, cold, heat, wind, sun, air conditioning, wet air and dry air), chemical (water and pollution) or psychological (emotional) factors. After cosmetics, the most important factors were wet air, OR 3.83 [2.48–5.91]; air conditioning, OR 3.60 [2.11–6.14]; heat, OR 3.5 [2.69–4.63]; and water, OR 3.46 [2.56–4.77].

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“…Within the wider concept of fragile skin, there is a reactive skin entity (also referred to as sensitive skin), which is a complex dermatological condition defined by the occurrence of unpleasant sensations (eg, stinging, burning, pain, pruritus, and tingling) in response to stimuli that normally should not provoke such sensations and that cannot be explained by lesions attributable to skin disease 3,16. A recent study has shown that the pathophysiology of skin sensitivity resembles that of neuropathic pruritus within the context of small fiber neuropathy, and that environmental factors may alter skin innervation 17.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of fragile skin: Internet-based surveys in Mexico and Russia

Ocampo‐Candiani

Мурашкин

Zkik

et al. 2017

CCID

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BackgroundFragile skin is a poorly understood skin condition, particularly in the general adult population. There are currently limited epidemiological data on the prevalence of fragile skin in adults. The objectives of this study were to assess the prevalence of perceived fragile skin across different skin types in representative samples of the general adult populations in Mexico and Russia, and to identify skin characteristics associated with perceived fragile skin.MethodsTwo identical cross-sectional surveys, using a short online self-administered questionnaire, were conducted on samples of recruited individuals that were representative of the general Mexican and Russian populations. Participants responded to questions about fragile skin, with the main question being “In your opinion, do you have fragile skin (ie, skin less resistant and reacting quickly to external aggressions)?”. The survey also covered questions relating to skin appearance, skin symptoms, skin disease, dermatological procedures, and living environment and climate.ResultsOverall, 1,210 individuals in Mexico (N=606) and Russia (N=604) completed the online survey. Fragile skin was perceived in 50.0% and 45.9% of participants in Mexico and Russia, respectively. The principal skin appearance characteristics reported by individuals with perceived fragile skin were thin, easily wrinkled, and transparent; the main skin symptoms were dryness, redness, and/or itching (≥50% of individuals in Mexico), and dryness, tightness, and/or redness (>60% of individuals in Russia). Individuals with perceived fragile skin had experienced skin disease and/or undergone a dermatological procedure in the past 12 months, and they reported being exposed to stress (>80% of individuals in both surveys).ConclusionA substantial proportion of the general adult population of Mexico and Russia perceived that they had fragile skin, regardless of their skin type; fragile skin was perceived more frequently in women. These findings should assist dermatologists to extend their understanding and management of individuals with perceived fragile skin.

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Definition of Sensitive Skin: An Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch

Cited by 156 publications

References 27 publications

Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel

Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel

Triggering factors in sensitive skin from the worldwide patients’ point of view: a systematic literature review and meta‐analysis

Epidemiology of fragile skin: Internet-based surveys in Mexico and Russia

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