Definition of Postprandial Lipaemia

Kolovou, Genovefa; Mikhailidis, Dimitri P.; Nordestgaard, Børge G.; Bilianou, Helen; Panotopoulos, George

doi:10.2174/157016111795495611

Cited by 51 publications

(26 citation statements)

References 97 publications

(137 reference statements)

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“…To this aim, the evaluation of flow mediated dilatation 92 , circulating biomarkers of the metabolic status 166,167 , peripheral blood mononuclear cells gene expression profile 103 or of the effect of specific TRL fractions on endothelial cells and macrophage gene expression/function 101,102 might represent an alternative approach. In summary, although fat loading tests need standardization 168,169 as they are a more complex compared to the glucose tolerance test, a careful evaluation of postprandial lipemia will help to better stratify patients with dyslipidemia and hypertriglyceridemia.…”

Section: Discussionmentioning

confidence: 99%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

102

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High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

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Section: Discussionmentioning

confidence: 99%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

102

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“…Currently, there is renewed interest in the usefulness of measuring non-fasting TGs, as a more powerful and independent predictor of CVD risk than fasting levels [43]. In this context, an expert panel provided a consensus statement on the classification of non-fasting TGs concentration and other related clinical recommendations [44].…”

Section: Overweight Obesity and Sdldlmentioning

confidence: 99%

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

et al. 2013

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Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in these subjects. Statins are the lipid-lowering drug of choice. Also, anti-obesity and lipid lowering drugs other than statins could be useful in these patients. However, the effects of anti-obesity drugs on CVD risk factors remain unclear. We review the clinical significance of sdLDL in being overweight and obesity, as well as the efficacy of anti-obesity drugs on LDL subfractions in these individuals; a short comment on HDL subclasses is also included. Our literature search was based on PubMed and Scopus listings. Further research is required to fully explore both the significance of sdLDL and the efficacy of anti-obesity drugs on LDL subfractions in being overweight, obesity and MetS. Improving the lipoprotein profile in these patients may represent an efficient approach for reducing cardiovascular risk.

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“…At present there is still no widely agreed definition of postprandial lipemia [48]. There is also conflicting information on blood collection and platelet processing regarding fasting and feeding states [18].…”

Section: Discussionmentioning

confidence: 99%

Platelet function in the postprandial period

Sinzinger

Berent²

2012

Thrombosis J

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BackgroundPostprandial hyperlipidemia and hyperglycemia have been related to cardiovascular events. Among different underlying mechanisms platelet activation seems to be responsible too. No comparable data between various tests in normo- vs. hyperlipidemics before and at different time intervals are available after a fat meal. We aimed to compare 9 of them within the same patients at several time points in postprandial hyperlipidemia.ResultsFor some tests baseline values between the groups were significantly different (TXB2, platelet sensitivity, sedimentation and WU-test). However, hyperlipidemia revealed a variable influence on the tests examined. Some of the available tests apparently sensitive to show platelet activation reflect the increase in triglycerides (TG), such as the sedimentation index. ADP-induced platelet aggregatory activity in count adjusted washed isolated platelet samples during postprandial hyperlipidemia indicates mildly enhanced platelet activity, but does not seem to induce significant changes in aggregation. In patients with severe hypertriglyceridemia (> 400 mg/dl fasting) changes in platelet function are more pronounced due to delayed decay and may last up to 16 hours paralleling TG reaching the prevalue. The overwhelming majority of platelet function tests do not significantly respond to postprandial hyperlipidemia. The correlation between the tests applied is poor. For standardization purpose, platelet aggregation tests, aimed to examine proaggregatory capacity in atherosclerosis, should only be performed at the same time of the day after a fasting period > 6 hours. The great variation in preanalytical work-up on comparison of various tests, large number of platelet tests available and their respective potential value are discussed.ConclusionsAt present, the suspicion that platelet function is significantly activated in the postprandial period cannot be supported by any of the tests used. The information provided is valuable to know for which test and group of patients a fasting period of which duration is recommendable.

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Definition of Postprandial Lipaemia

Cited by 51 publications

References 97 publications

Postprandial lipemia as a cardiometabolic risk factor

Postprandial lipemia as a cardiometabolic risk factor

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

Platelet function in the postprandial period

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