Definition and significance of high positivity aCL ELISA

Wahl, Denis; Devignes, J.; Mohamed, S. D.; Zuily, Stéphane; Lecompte, T.

doi:10.1177/0961203312443298

Cited by 5 publications

(3 citation statements)

References 8 publications

(11 reference statements)

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“…Patients found LA‐positive, and those with high IgG aCL titres or with high LA ratios (which can be considered as result of a high titre as well) at initial testing, were significantly more frequent in the EPP than in the NPP group. This extends existing reports concerning confirmation at 12 weeks, showing that the presence of a LA is associated with aPL persistence at that time point and that patients with transient aPL positivity have lower aCL titres than patients with confirmed aPL positivity …”

Section: Discussionsupporting

confidence: 88%

“…IgG and IgM aβ 2 GPI ELISAs were performed with a commercially available kit (Orgentec ® ). For both ELISAs, the calibration was performed according to Harris's standards and the thresholds for positivity were defined as the 99th percentile of the titre measured in a population of more than 170 healthy blood donors . The cut‐off values for aCL positivity were equal to 14 GPL and 5 MPL for IgG and IgM, respectively, and those for aβ 2 GPI positivity were equal to 8 GPL and 8 MPL for both IgG and IgM.…”

Section: Patients Materials and Methodsmentioning

confidence: 99%

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Extended persistence of antiphospholipid antibodies beyond the 12‐week time interval: Association with baseline antiphospholipid antibodies titres

Devignes¹,

Smaïl-Tabbone

Hervé

et al. 2019

Int J Lab Hematology

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Introduction The confirmation time interval for the presence of antiphospholipid antibodies (aPL) has been extended to 12 weeks as epiphenomenal antibodies may disappear after 6 weeks. Our aim was to analyse extended persistence of aPL positivity beyond the 12‐week interval. Methods We retrospectively analysed our database of 23 856 aPL test samples collected between 2005 and 2017 from 17 367 consecutive patients. Two groups of patients were identified among aPL‐positive patients, confirmed at 12 weeks: with or without extended persistence beyond confirmatory testing. Percentages of extended persistence are given according to the initial aPL positivity profiles, and baseline laboratory variables are compared between the two groups. Results Three hundred and twenty‐seven patients confirmed aPL‐positive had subsequent testing. The vast majority of them displayed extended persistence in the long term: 89.6% and up to 97.9% for patients with initial triple positivity. In extended persistent positive patients, there were more LA‐positive initial samples, and baseline LA test values and IgG aCL titres were higher than in nonpersistent positive patients. Conclusion Data from a large database of an aPL referral laboratory showed that the time interval of 12 weeks defining persistence of aPL positivity was appropriate for the majority of patients. Furthermore, we found baseline features associated with extended persistence.

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Section: Discussionsupporting

confidence: 88%

Section: Patients Materials and Methodsmentioning

confidence: 99%

Extended persistence of antiphospholipid antibodies beyond the 12‐week time interval: Association with baseline antiphospholipid antibodies titres

Devignes¹,

Smaïl-Tabbone

Hervé

et al. 2019

Int J Lab Hematology

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show abstract

“…Unlike triple‐positive and double‐positive subjects, single‐positive subjects had laboratory data confirmed after 12 weeks in 40% of cases. A similar figure (53 of 91 had persistent positivity at 12 weeks) was recently found in patients with medium/high aCL positivity (> 99th percentile) . However, subjects with persistent aCL had higher values than subjects with transient aCL, the latter being close to medium‐positivity thresholds .…”

Section: Discussionsupporting

confidence: 82%