2018
DOI: 10.1167/iovs.17-23475
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Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions

Abstract: The definition and diagnostic criteria of dry eye disease (DED) proposed by the Japan Dry Eye Society and other countries are reviewed. The first definition and criteria of DED in Japan were proposed in 1995. In that report, DED was considered a disease of tears, which subsequently damaged ocular epithelia. The presence of subjective symptoms was not included in the criteria. In 2006, a new definition proposed that interactions between the tear film and ocular surface epithelia play important roles in DED. The… Show more

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Cited by 147 publications
(133 citation statements)
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“… 25 Although the overlap between the various definitions can be appreciated, this lack of consensus demonstrates the complex nature of DED. 26 …”
Section: The Background Of Dedmentioning
confidence: 99%
“… 25 Although the overlap between the various definitions can be appreciated, this lack of consensus demonstrates the complex nature of DED. 26 …”
Section: The Background Of Dedmentioning
confidence: 99%
“…Dry eye disease (DED) is a multifactorial ocular surface disease characterized by a loss of tear lm homeostasis. 1,2 In the 2017 Tear Film and Ocular Surface society (TFOS) Dry Eye Workshop (DEWS) II report, DED was classi ed into aqueous de cient dry eye (ADDE) and evaporative dry eye. ADDE is categorized into two groups, Sjögren's syndrome (SS)-related dry eye and non-SS DED.…”
Section: Introductionmentioning
confidence: 99%
“…Aqueous tear deficiency dry eye (ATD) is characterized by unstable tear film caused by the decrease of tear produce of lacrimal glands and the quality of aqueous tears, which can be divided into Sjögren's syndrome and non Sjögren's syndrome [3] [4]. ATD can cause eye symptoms such as irritation, foreign body feeling, fatigue and so on [4].…”
Section: Introductionmentioning
confidence: 99%