Definition and biomarkers of acute renal damage: New perspectives

Seija, Mariana; Baccino, Cecilia; Nin, Nicolás; Lorente, José A.

doi:10.1016/j.medine.2013.09.003

Cited by 8 publications

(10 citation statements)

References 68 publications

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“…Consequently, these enzymes are secreted by the tubular epithelial cells and they are excreted in the urine as a response to the AKI; among these, N-Acetyl-b-glucosaminidase (NAG), cytoplasmic protein lactate dehydrogenase and glycoprotein 130 (gp130) [15][16][17]. The secreted enzymes are the biomarkers themselves, which are classi ied based on their role in the pathophysiology of AKI [18][19][20][21] (Table 1).…”

Section: Pathophysiology Of Akimentioning

confidence: 99%

“…Their main advantage is their low cost; despite this, it depends on the urinary pH, decreasing its effectiveness if the pH is less than 5.5 [22]. A retrospective Table 1: Classifi cation and biomarkers of AKI with the highest relevance [18][19][20][21]. Each one of them has diff erent properties as a biomarker (e.g., increasing the sensitivity of the diagnoses, predict prognosis, etc.).…”

Section: Alpha-1 Microglobulin and Beta-2 Microglobulinmentioning

confidence: 99%

“…Each one of them has diff erent properties as a biomarker (e.g., increasing the sensitivity of the diagnoses, predict prognosis, etc.). On the other hand, it has been proposed that the use of a panel of several biomarkers can improve their individual properties [18].…”

Section: Alpha-1 Microglobulin and Beta-2 Microglobulinmentioning

confidence: 99%

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Biomarkers in acute kidney injury

Pájaro-Galvis¹

2020

J Clini Nephrol

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Acute kidney injury is a common condition associated with high morbidity and short-term mortality. Its pathophysiology varies according to the numerous conditions associated with its genesis. Biomarkers allow detecting changes at the level of kidney function; therefore, they play an important role in the prevention, early diagnosis, therapeutic response and prognosis of acute kidney injury. The search for biomarkers for acute kidney injury began over 15 years ago; initially, only serum creatinine was available for diagnosis. However, throughout history, great advances have been made in research, which have allowed the fi nding of new biomarkers in order to improve the health and quality of life of patients. A narrative review of the literature is carried out on the basis of available scientifi c evidence to clarify the role and importance of biomarkers in the context of acute renal injury. serum creatinine (sCr), knowing that a signi icant reduction in the glomerular iltration rate will increase the sCr [1]. Until the year 2002, there was no standardized de inition More Information

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Section: Pathophysiology Of Akimentioning

confidence: 99%

Section: Alpha-1 Microglobulin and Beta-2 Microglobulinmentioning

confidence: 99%

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Biomarkers in acute kidney injury

Pájaro-Galvis¹

2020

J Clini Nephrol

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“…Therefore, further studies are needed to determine the diagnostic value of IL-18 in both AKI and CKD including the relationship of IL-18 concentration with the progression of kidney injury. 12,25,36,41 There are no data on IL-18 levels in children with kidney cysts.…”

Section: Introductionmentioning

confidence: 99%

Angiotensinogen and interleukin 18 in serum and urine of children with kidney cysts

Plesiński¹,

Adamczyk

Świętochowska

et al. 2019

J Renin Angiotensin Aldosterone Syst

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Background: The most common disease associated with the presence of kidney cysts in the population is autosomal dominant polycystic kidney disease (ADPKD), which finally leads to end-stage renal disease. Method: The study evaluated serum and urinary concentration of angiotensinogen (AGT) and interleukin 18 (IL-18) in a group of 39 children with renal cysts of different aetiology. Results: Serum and urinary AGT concentration in children with renal cysts was higher compared to controls, regardless of the underlying background and gender. Serum IL-18 concentration was lower, in contrast, and the concentration of IL-18 in the urine did not differ between affected and healthy children. Negative correlation between urinary IL-18 concentration and systolic and mean arterial blood pressure was noted. Conclusions: Higher AGT levels in serum and urine in children with renal cysts may indicate the activation of the renin–angiotensin–aldosterone system, including its intrarenal part, even before the onset of hypertension. Lower serum concentration of IL-18 in children with kidney cysts may indicate the loss of the protective role of this cytokine with the occurrence of hypertension.

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“…Por ello, se busca poder identificar precozmente a los pacientes con riesgo a desarrollar DRA, de forma más selectiva y específica que con los métodos actuales tras recibir un tratamiento quimioterápico (Seijas et al, 2014). Para ello, se están investigando biomarcadores de predisposición, que se definen como moléculas asociadas a patrones anatomopatológicos o a mecanismos patogénicos definidos, que detectan la sensibilidad a sufrir un daño renal y permiten clasificar a los pacientes en base a ella (Segarra-Medrano et al, 2012).…”

Section: Introductionunclassified

Biomarcadores de nefrotoxicidad capaces de identificar pacientes oncológicos en riesgo de desarrollar daño renal

2019

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Cisplatino y carboplatino son dos fármacos muy usados en el tratamiento de tumores sólidos. Sin embargo, su eficacia está limitada por su nefrotoxicidad. Se ha demostrado que un 25-30% de los pacientes tratados con estos fármacos ha acabado desarrollando un daño renal agudo (DRA). En la actualidad, el diagnóstico del DRA se lleva a cabo mediante el uso de biomarcadores tales como creatinina plasmática y urea, pero resultan poco sensibles y específicos. El objetivo de este trabajo se centra en la búsqueda de biomarcadores urinarios capaces de predecir la aparición de un fallo renal, antes incluso de comenzar dicho tratamiento, siendo capaces de clasificar a los pacientes de acuerdo con su sensibilidad, predecir la evolución de su función renal y llevar a cabo un tratamiento más adaptado a cada paciente.Un estudio clínico fue llevado a cabo con pacientes voluntarios del Servicio de Oncología del Hospital Universitario de Salamanca. Los biomarcadores estudiados fueron proteinuria, N-acetil-?-glucosaminidasa (NAG), Lipocalina asociada a la gelatinada de neutrófilos (NGAL) y albúmina. Para la cuantificación de estos biomarcadores se utilizaron técnicas colorimétricas y la técnica ELISA.Los resultaron mostraron que los niveles de los biomarcadores en el grupo Casos son significativamente superiores a los del grupo Control, tanto en el momento anterior al máximo daño renal, como en el momento basal, lo que nos permitiría saber cuáles son los pacientes que tendrían más probabilidad de sufrir un daño renal antes de iniciar el tratamiento. Dichos marcadores serían un gran avance en el tratamiento quimioterápico, ya que nos permitirían un tratamiento más preventivo y personalizado de cada paciente.

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Definition and biomarkers of acute renal damage: New perspectives

Cited by 8 publications

References 68 publications

Biomarkers in acute kidney injury

Biomarkers in acute kidney injury

Angiotensinogen and interleukin 18 in serum and urine of children with kidney cysts

Biomarcadores de nefrotoxicidad capaces de identificar pacientes oncológicos en riesgo de desarrollar daño renal

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