Definition and biological significance of the major histocompatibility system (MHS) in man and animals

Dam, R.H. Van

doi:10.1016/0165-2427(81)90013-1

Veterinary Immunology and Immunopathology

1981

DOI: 10.1016/0165-2427(81)90013-1

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Definition and biological significance of the major histocompatibility system (MHS) in man and animals

R.H. Van Dam

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1982

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Cited by 11 publications

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“…The major histocompatibility complex (MHC) of the dog (DLA) codes for three classes of gene products, similar to most other vertebrate species studied (van Dam 1981, Grosse-Wilde et al 1983. While the serologically defined genetic loci (DLA-A,B,C) control a total of 15 class I alloantigens, one locus (DLA-D) recognized by reactivity in the mixed lymphocyte culture and coding for at least 10 alleles (Grosse-Wilde et al 1975, Vriesendorp et al 1977, Joint Report of the 3rd International Workshop on Canine Immunogenetics) represents class I1 antigens.…”

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confidence: 99%

Revised classification of the DLA loci by serological studies

Krumbacher¹,

Feltz

Happel³

et al. 1986

Tissue Antigens

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Peripheral blood mononuclear cells from DLA typed dogs were treated with rabbitanti-dog-µglobulin and subsequently with goat-anti-rabbit-immunoglobulin in order to aggregate the DLA class I molecules on the cell membrane (lysostrip). Utilizing a panel of 70 defined DLA-A and DLA-B antisera, lymphocytes treated in this way showed resistance to complement dependent lysis with monospecific DLA-A sera only, whereas reactivity of DLA-B antisera was not blocked; on the contrary, complete lympholysis with each DLA-B antiserum was recognized. Thus, the DLA-B antigens, evidently not associated with f&-microglobulin, are designated as candidates for class I1 gene products. The different reactions of DLA-C antisera after lysostrip did not allow a precise assignment of this antigen series as yet.

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mentioning

confidence: 99%

Revised classification of the DLA loci by serological studies

Krumbacher¹,

Feltz

Happel³

et al. 1986

Tissue Antigens

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The canine major histocompatibility complex. Supertypic specificities defined by the Primed Lymphocyte Test (PLT)

Ladiges

Brown

et al. 1984

Immunogenetics

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Preliminary studies of the feline histocompatibility system

et al. 1982

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Definition and biological significance of the major histocompatibility system (MHS) in man and animals

Cited by 11 publications

References 113 publications

Revised classification of the DLA loci by serological studies

Revised classification of the DLA loci by serological studies

The canine major histocompatibility complex. Supertypic specificities defined by the Primed Lymphocyte Test (PLT)

Preliminary studies of the feline histocompatibility system

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