Defining neonatal sepsis

Wynn, James L.

doi:10.1097/mop.0000000000000315

Cited by 270 publications

(254 citation statements)

References 79 publications

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“…Several patients in our study were assigned a culture‐negative EONS diagnosis and received antibiotic treatment for at least three days, despite low CRP values. A review concluded that the lack of an accepted consensus definition for neonatal sepsis impeded efforts towards improved diagnostic and prognostic options for this condition . We found some marked clinical and laboratory differences between culture‐confirmed EONS and culture‐negative EONS.…”

Section: Discussionmentioning

confidence: 81%

Management of early‐onset neonatal sepsis differs in the north and south of Scandinavia

et al. 2017

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Section: Discussionmentioning

confidence: 81%

Management of early‐onset neonatal sepsis differs in the north and south of Scandinavia

et al. 2017

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“…El distrés respiratorio, la bradipnea y la hipotonía (79%, 52% y 40% respectivamente), fueron los síntomas más comunes entre los pacientes del estudio, lo cual es similar a lo descrito en la literatura 10 . A pesar que en los criterios diagnósticos de infección se encuentra la distermia y la taquicardia como predictores de infección neonatal 4 , en nuestro estudio las alteraciones en la frecuencia cardiaca y en la temperatura sucedieron en menos del 40% de los pacientes.…”

Section: Discussionunclassified

“…La sepsis se define como un estado de respuesta inflamatoria sistémica que se diagnostica en los recién nacidos según factores de riesgo perinatales (fiebre materna, madre con corioamionitis, ruptura prematura de membranas de más de 18 horas, pobre control prenatal) 4 , manifestaciones clínicas (distermias, taquicardia/bradicardia, taquipnea/bradipnea, alteraciones del sistema nervioso central como letargia/irritabilidad o hipotonía, distrés respiratorio, hipoperfusión) y alteraciones paraclínicas (leucocitosis o leucopenia, bandas, PCR/procalcitonina elevada, trombocitopenia) incluyendo cultivos 5 .…”

Section: Introductionunclassified

Características clínicas y paraclínicas de recién nacidos con sepsis en un hospital nivel IV en Cali, Colombia

Pérez-Camacho

Pino-Escobar

Cleves

et al. 2018

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Cómo citar este artículo: P. Pérez-Camacho, et al. Características clínicas y paraclínicas de recién nacidos con sepsis en un hospital nivel IV en Cali, Colombia. Infectio 2018; 22(3): 141-146 Resumen Objetivo: Describir las características clínicas y microbiológicas de recién nacidos con sepsis admitidos a UCI neonatal de la Fundación Valle del Lili. Materiales y métodos: estudio retrospectivo descriptivo entre los años 2012 y 2015. Se seleccionaron neonatos con diagnóstico de sepsis con más de tres días de manejo antibiótico. Resultados: Se analizaron datos de las historias de 569 pacientes. El 37.9% (216) de los neonatos tenían peso al nacimiento <1500 g, 29.2% (166) entre 1500-2500 g, y 33.9% (187) >2500 g. Para un total de 396 (69.6%) pacientes con sepsis temprana, 308 (54.1%) con sepsis tardía. Las características clínicas más comunes fueron las respiratorias. El principal diagnóstico de infección en sepsis tardía fue la bacteremia (46.4%), seguido de la infección asociada al catéter (17.8%). El aislamiento más común para sepsis temprana fue Streptococcus agalactiae en el 21.9%, mientras que en sepsis tardía fue Staphylococcus epidermidis en el 22.6%. La mortalidad encontrada en sepsis temprana fue de 8.8% y en tardía de 8.5%. Conclusiones: La sepsis neonatal, a pesar de la mejoría en los controles prenatales, continúa siendo una patología frecuente con un importante porcentaje de morbimortalidad. El Streptococcus agalactiae fue la principal causa de sepsis temprana en nuestros pacientes. Palabras clave: Sepsis, Infección, Neonatos. Clinical and laboratory characteristics of newborns with sepsis in a level IV hospital in Cali, Colombia AbstractObjective: To describe the clinical and microbiological characteristics of newborns with sepsis admitted to the Neonatal Intensive Care Unit of Fundación Valle del Lili in Cali, Colombia. Methods: Descriptive, observational, retrospective study between 2012 and 2015. We included newborns with diagnosis of sepsis with more than three days of antibiotic management. Results: A total of 569 patients were included, 37.9% (216) of the newborns had a birth weight <1500g, 29.2% (166) between 1500 and 2500g , and 32.9% (187) >2500g. 396 (69.6%) patients with early-onset sepsus, 308 (54.1%) had late-onset sepsis. The most common clinical characteristics were respiratory symptoms. The main diagnosis of infection in late-onset sepsis was bacteremia (46.4%) followed by catheter associated infection (17.8%). The most common blood culture isolation for early-onset sepsis was Streptococcus agalactiae (21.9%) and Staphylococcus epidermidis in late onset sepsis (22.6%). The mortality found in early-onset sepsis was 8.8% and in late-onset sepsis was 8.5%. Conclusions: Neonatal sepsis continue to be a frequent diagnosis with significant morbidity and mortality. Better strategies for the prevention of this entity are required including the prenatal period.

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“…Neonatal sepsis is a global challenge causing high morbidity and mortality among newborns [1][2][3][4]. The global infant mortality rate in 2014 was 29 per 1000 live births-the common cause being infection [5].…”

Section: Introductionmentioning

confidence: 99%

Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand

et al. 2020

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Background: Early diagnosis of neonatal sepsis is essential to prevent severe complications and avoid unnecessary use of antibiotics. The mortality of neonatal sepsis is over 18%in many countries. This study aimed to develop a predictive model for the diagnosis of bacterial late-onset neonatal sepsis. Methods: A case-control study was conducted at Queen Sirikit National Institute of Child Health, Bangkok, Thailand. Data were derived from the medical records of 52 sepsis cases and 156 non-sepsis controls. Only proven bacterial neonatal sepsis cases were included in the sepsis group. The non-sepsis group consisted of neonates without any infection. Potential predictors consisted of risk factors, clinical conditions, laboratory data, and treatment modalities. The model was developed based on multiple logistic regression analysis. Results: The incidence of late proven neonatal sepsis was 1.46%. The model had 6 significant variables: poor feeding, abnormal heart rate (outside the range 100-180 x/min), abnormal temperature (outside the range 36 o -37.9°C), abnormal oxygen saturation, abnormal leucocytes (according to Manroe's criteria by age), and abnormal pH (outside the range 7.27-7.45). The area below the Receiver Operating Characteristics (ROC) curve was 95.5%. The score had a sensitivity of 88.5% and specificity of 90.4%.Conclusion: A predictive model and a scoring system were developed for proven bacterial late-onset neonatal sepsis. This simpler tool is expected to somewhat replace microbiological culture, especially in resource-limited settings.

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Defining neonatal sepsis

Cited by 270 publications

References 79 publications

Management of early‐onset neonatal sepsis differs in the north and south of Scandinavia

Management of early‐onset neonatal sepsis differs in the north and south of Scandinavia

Características clínicas y paraclínicas de recién nacidos con sepsis en un hospital nivel IV en Cali, Colombia

Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand

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