Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand

Husada, Dominicus; Chanthavanich, Pornthep; Chotigeat, Uraiwan; Sunttarattiwong, Piyarat; Sirivichayakul, Chukiat; Pengsaa, Krisana; Chokejindachai, Watcharee; Kaewkungwal, Jaranit

doi:10.1186/s12879-020-4875-5

Cited by 25 publications

(26 citation statements)

References 66 publications

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“…According to maternal factors, It was found no significant difference between septic cases and controls in terms of maternal age, maternal diseases, maternal medications, maternal exposure to radiation or smoking, fever in pregnancy, previous abortion, still birth and family history (p > 0.05). These results were in accordance with (Husada et al, 2020) findings [ 17 ] and on the contrast with (Siakwa et al, 2014) [ 18 ] who showed that the maternal factors were significantly associated with neonatal sepsis.…”

Section: Discussionsupporting

confidence: 92%

The diagnostic and prognostic role of MiRNA 15b and MiRNA 378a in neonatal sepsis

Fouda

Midan

Ellaban

et al. 2021

Biochemistry and Biophysics Reports

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Background and objectives Sepsis is one of the major factors for both term and preterm babies with morbidity and mortality. On the basis of recent clinical trials, altered circulating micro-RNAs (miRNAs) may serve as possible biomarkers in sepsis for diagnosis and prognosis. The aim of this research is to assess the diagnostic and prognostic biomarkers of miRNA 15b and miRNA 378a for neonatal sepsis. Subjects & methods This study was carried out 25 neonates with sepsis admitted to neonatal ICU of Menoufia University Hospital and 25 healthy controls from February 2019 to May 2020. The relative quantification (RQ) of miRNA-15b and miRNA-378a expression was assessed using real time PCR technique. Results: Our results demonstrated that patients with sepsis had significantly higher level of MiRNA-15b than the healthy volunteers. On the other hand, patients with sepsis had significantly lower level of MiRNA-378a than the healthy volunteers. The ROC curve showed that the serum MiRNA-15b was a significant discriminator of sepsis with a combined sensitivity and specificity of 76% and 88% with cutoff point of 3.24. In addition, serum MiRNA-378a was a significant discriminator of sepsis with a combined sensitivity and specificity of 60% and 88% with cutoff point of 0.361. The miRNA-15b expression significantly correlated positive with respiratory rate (r =0.415,p =0.039), WBCs (r = 0.408, p =0.043), and CRP (r =0.407, p=0.043). Likewise, miRNA-378a expression significantly correlated negative with respiratory rate (r =-0.415p =0.024), WBCs (r =- 0.442, p =0.027), and CRP (r =- 0.459, p=0.021). Conclusion Both MiRNA 15b and 378a are promising biomarker for neonatal sepsis.

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Section: Discussionsupporting

confidence: 92%

The diagnostic and prognostic role of MiRNA 15b and MiRNA 378a in neonatal sepsis

Fouda

Midan

Ellaban

et al. 2021

Biochemistry and Biophysics Reports

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“…For the outcome, most of died subjects had junior high school and senior high school mother education, neither bachelor mother had no died subjects. This finding also similar with Husada et al was found low educated mother were risk factor of neonatal LOS (78%) [12].…”

Section: Discussionsupporting

confidence: 90%

“…In addition Umate et al was found lethargic (68.75%) and respiratory distress (72.60%). Temperature instability and seizure also found as independent factors associated with serious CNS complication [12][13][14]. That statement is strengthened by our results in which there was no temperature instability (96%) neither seizure (96%) most of our subjects had good outcome (70%).…”

Section: Discussionsupporting

confidence: 74%

Characteristics of neonatal late onset sepsis in Sanglah Hospital, Bali

Prayoga¹,

Kardana²,

Artana³

et al. 2021

GSC Adv. Res. Rev.

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Neonatal Late-Onset Sepsis (LOS) is a leading cause of mortality in the Neonatal Intensive Care Unit (NICU). The microbial characteristics of LOS are of primary importance in guiding clinical antisepsis practice, and strategies to prevent and treat neonatal LOS, in turn, influence the pattern of LOS pathogens. This study is a retrospective descriptive study with a cross-sectional approach conducted between 2016 until 2020 in the neonatal ward (level II-III) of the Sanglah General Hospital, Bali. Data collected consists of demography, clinical characteristics, laboratory results, and outcomes. Subjects in this study dominated by male (64%), gestational age > 37 weeks (56%), born ≥ 2.500 grams (54%), last mother education mostly in Senior High School (56%), spontaneous delivery method (54%) and 31 (62%) subjects were referral from other hospital and primary health care. Most of the subjects were lethargic (68%) and 15 (30%) subjects were died. Laboratory finding normal leukocyte, neutrophil, lymphocyte, hemoglobin, thrombocyte and IT ratio but have higher procalcitonin result. Poor outcome group were dominated by male, smaller gestational age, VLBW, and neonates who experience lethargy, temperature instability, respiratory distress and got positive blood culture.

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“…Klebsiella pneumoniae and CONS were the most common microorganisms. These data were comparable with other developing countries [49,50,51] in LONNS.…”

Section: Discussionsupporting

confidence: 86%

Early Onset and Late Onset of Neonatal Sepsis in a Tertiary Hospital, South-South, Nigeria

Adedokun

Onosakponome²,

Nyenke³

2020

JAMB

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Aims: The study was carried out to determine organisms present during early onset of neonatal sepsis (EONNS), late onset of neonatal sepsis (LONNS) and their antimicrobial susceptibility pattern. Methodology: This study is a retrospective evaluation of 453 neonatal blood cultures. Two (2) ml of blood from these neonates was cultured in thioglycollate broth and tryptone soya broth. This was carried out in the Department of Microbiology and Parasitology of the University of Port Harcourt Teaching Hospital, Nigeria between January-December 2007. Results: Out of 453, 272(60.0%) neonates showed negative blood cultures, while 181(40.0%) neonates had positive bacterial cultures and 2 neonates (0.4%) were positive for Candida albicans. Overall, Klebsiella spp. was the most common pathogen, accounting for (37.8%) of the total isolates. Others were as follows; Staphylococcus aureus (28.4%), Escherichia coli (11.8%), unclassified coliforms 8.3%, Pseudomonas spp. 4.9%, Enterococcus spp. (2.9%), coagulase-negative Staphylococcus (CONS) (2.5%) and Proteus spp. (3.4%). Early onset neonatal sepsis (EONNS) and late onset neonatal sepsis (LONNS) had Klebsiella spp and Staphylococcus aureus as their common causes of neonatal sepsis respectively. Klebsiella spp. was susceptible to spafloxacin (87.0%) followed by ofloxacin (82.0%), amoxycillin-clavulanic acid (79.0%) and ceftazidime (65.0%) among the Gram-negative organisms. In the category of Gram-positive organisms, Staphylococcus aureus is highly sensitive to ofloxacin (81.0%) followed by spafloxacin (79.0%) and amoxicillin-clavulanic acid (71.0%). Conclusion: A viable antibiotic susceptibility surveillance programme coupled with good infection control practices and rational antibiotics use will reduce infection rate, ensure better therapeutic success and prolong the efficacy of available antimicrobials.

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Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand

Cited by 25 publications

References 66 publications

The diagnostic and prognostic role of MiRNA 15b and MiRNA 378a in neonatal sepsis

The diagnostic and prognostic role of MiRNA 15b and MiRNA 378a in neonatal sepsis

Characteristics of neonatal late onset sepsis in Sanglah Hospital, Bali

Early Onset and Late Onset of Neonatal Sepsis in a Tertiary Hospital, South-South, Nigeria

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