Defining clinical cut-offs for albumin:creatinine ratio

Bakker, Stephan J. L.

doi:10.1038/nrneph.2013.233

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…In type 1 diabetes, a higher UA level is associated with a higher risk of decline in kidney function and mortality [45]. CREA, existing in blood and urine, is the key biomarker for assessing chronic kidney disease and monitoring its progress in clinical medicine [46]. In the rat model of chronic kidney disease, increases in Eggerthellalenta and Fusobacterium nucleatum in the gut microbiota increased the production of urinary toxins and accelerated the progression of kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

et al. 2021

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Hericium erinaceus (H. erinaceus) is widely studied as a medicinal and edible fungus. Recent studies have shown that H. erinaceus has protective effects for diseases, such as inflammatory bowel disease and cancer, which are related to gut microbiota. To investigate the benefits of H. erinaceus intake on gut microbiota and blood indices in adulthood, we recruited 13 healthy adults to consume H. erinaceus powder as a dietary supplement. Blood changes due to H. erinaceus consumption were determined by routine hematological examination and characterized by serum biochemical markers. Microbiota composition was profiled by 16S ribosomal RNA gene sequencing. Results showed that daily H. erinaceus supplementation increased the alpha diversity within the gut microbiota community, upregulated the relative abundance of some short-chain fatty acid (SCFA) producing bacteria (Kineothrix alysoides, Gemmiger formicilis, Fusicatenibacter saccharivorans, Eubacterium rectale, Faecalibacterium prausnitzii), and downregulated some pathobionts (Streptococcus thermophilus, Bacteroides caccae, Romboutsia timonensis). Changes within the gut microbiota were correlated with blood chemical indices including alkaline phosphatase (ALP), low-density lipoprotein (LDL), uric acid (UA), and creatinine (CREA). Thus, we found that the gut microbiota alterations may be part of physiological adaptations to a seven-day H. erinaceus supplementation, potentially influencing beneficial health effects.

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Section: Discussionmentioning

confidence: 99%

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

et al. 2021

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“…Microalbuminuria was defined as uACR >2.5–30 mg/mmol for males and >3.5–30 mg/mmol for females. Macroalbuminuria was defined as uACR >30 mg/mmol [ 15 ]. eGFR was computed using the modified Modification of Diet in Renal Disease formula [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation

Salman

Said

et al. 2022

Annals of Medicine

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Purpose Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in patients with pre-existing DM. Methods This retrospective study involved 103 type II diabetic patients with end-stage liver disease who received LDLT. Preoperative spot urine albumin: creatinine ratio was used to determine the degree of albuminuria. The primary outcome measure was the impact of urinary albumin excretion on the 3-year mortality rate after LDLT in this diabetic cohort. Results Hepatitis C virus infection was the main cause of cirrhosis. Albuminuria was detected in 41 patients (39.8%); 15 had macroalbuminuria, while 26 had microalbuminuria. Patients with microalbuminuria were significantly older than those with macroalbuminuria and normal albumin in urine. After 3 years, twenty-four patients (23.3%) died within 3 years after LT. Myocardial infarction was the leading cause of death (25%). Albuminuria was an independent factor affecting 3-year mortality with an odds ratio of 5.17 (95% CI: 1.86–14.35). Conclusion Preoperative albuminuria is an independent factor affecting mortality within 3 years after LDLT in type II diabetic patients. Myocardial infarction was the leading cause of death in 25% of cases, followed by hepatocellular carcinoma recurrence, sepsis, and graft failure. KEY MESSAGES Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. Preoperative albuminuria is a significant predictor of mortality within 3 years after LDLT in diabetic patients.

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“…This is possible because creatinine is excreted in the urine at a relatively constant rate, and normalization of random urinary albumin to creatinine accounts for urinary dilution variations. 7,8 Furthermore, albumin-to-creatinine ratio cutoffs are available for determining the level of renal failure. For example, urinary albuminuria values greater than 3 mg mmol −1 , persisting for more than 3 months, is part of the diagnostic criteria and staging of CKD.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous quantitation of urinary albumin and creatinine for rapid clinical albuminuria diagnostics using high-throughput paper spray mass spectrometry

Pereira,

Robinson,

Gill

2024

Analyst

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Defining clinical cut-offs for albumin:creatinine ratio

Cited by 3 publications

References 6 publications

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study

Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation

Simultaneous quantitation of urinary albumin and creatinine for rapid clinical albuminuria diagnostics using high-throughput paper spray mass spectrometry

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